FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113443030> ?p ?o ?g. }

• W2113443030 endingPage "62" @default.
• W2113443030 startingPage "153" @default.
• W2113443030 abstract "Chondrocyte differentiation is a fundamental process during endochondral ossification. Retinoic acid (RA) has been shown to regulate this process, however, the mechanisms underlying RA regulation of chondrogenesis are not clearly understood. Chondroprogenitor cells, ATDC5 have been shown to be a useful in vitro model for examining the multiple step differentiation of chondrocytes. The present study investigated the mechanisms underlying RA regulation of chondrogenesis using ATDC5 cell culture. In this study, we show that RA suppresses the cell growth, cartilage nodule formation, accumulation of proteoglycan, alkaline phosphatase (ALPase) activity and mineralization and that RA dose dependently upregulates the levels of type X collagen and matrix metalloproteinase-13 (MMP-13) mRNA which are marker proteins of hypertrophic chondrocytes, in ATDC5 cells. The addition of protein synthesis inhibitor, cycloheximide (CHX), partially inhibits the induction of type X collagen and MMP-13 mRNA by RA. In this system, RA upregulates the mRNA level of Runx2/Cbfa1 (type II), a positive regulator for mineralization, and downregulates the mRNA of Indian hedgehog (Ihh), parathyroid hormone related protein (PTHrP), negative regulators for terminal differentiation. However, RA downregulates ALPase, bone gla protein (BGP) mRNAs and mineralization. These data indicate that RA stimulates cartilage differentiation, however, cell condensation and cartilage nodule formation may be candidates of primary importance in the terminal differentiation of chondrocytes." @default.
• W2113443030 created "2016-06-24" @default.
• W2113443030 creator A5004757230 @default.
• W2113443030 creator A5052040526 @default.
• W2113443030 creator A5058776872 @default.
• W2113443030 creator A5084562769 @default.
• W2113443030 date "2005-09-01" @default.
• W2113443030 modified "2023-09-27" @default.
• W2113443030 title "Effects of retinoic acid on the differentiation of chondrogenic progenitor cells, ATDC5." @default.
• W2113443030 cites W1808478176 @default.
• W2113443030 cites W1963714463 @default.
• W2113443030 cites W1967951907 @default.
• W2113443030 cites W1970923613 @default.
• W2113443030 cites W1976443161 @default.
• W2113443030 cites W1977979327 @default.
• W2113443030 cites W1982227963 @default.
• W2113443030 cites W1988965815 @default.
• W2113443030 cites W1992776027 @default.
• W2113443030 cites W1995499476 @default.
• W2113443030 cites W1997717120 @default.
• W2113443030 cites W2000780867 @default.
• W2113443030 cites W2005236657 @default.
• W2113443030 cites W2006537158 @default.
• W2113443030 cites W2014333311 @default.
• W2113443030 cites W2019663306 @default.
• W2113443030 cites W2027932074 @default.
• W2113443030 cites W2033713152 @default.
• W2113443030 cites W2052886229 @default.
• W2113443030 cites W2062674316 @default.
• W2113443030 cites W2073719628 @default.
• W2113443030 cites W2085530184 @default.
• W2113443030 cites W2086722866 @default.
• W2113443030 cites W2091246953 @default.
• W2113443030 cites W2094407798 @default.
• W2113443030 cites W2116903136 @default.
• W2113443030 cites W2117005096 @default.
• W2113443030 cites W2124594962 @default.
• W2113443030 cites W2156423290 @default.
• W2113443030 cites W2415296853 @default.
• W2113443030 cites W2336236247 @default.
• W2113443030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16350840" @default.
• W2113443030 hasPublicationYear "2005" @default.
• W2113443030 type Work @default.
• W2113443030 sameAs 2113443030 @default.
• W2113443030 citedByCount "5" @default.
• W2113443030 countsByYear W21134430302015 @default.
• W2113443030 countsByYear W21134430302018 @default.
• W2113443030 countsByYear W21134430302022 @default.
• W2113443030 crossrefType "journal-article" @default.
• W2113443030 hasAuthorship W2113443030A5004757230 @default.
• W2113443030 hasAuthorship W2113443030A5052040526 @default.
• W2113443030 hasAuthorship W2113443030A5058776872 @default.
• W2113443030 hasAuthorship W2113443030A5084562769 @default.
• W2113443030 hasConcept C104317684 @default.
• W2113443030 hasConcept C105702510 @default.
• W2113443030 hasConcept C126322002 @default.
• W2113443030 hasConcept C134018914 @default.
• W2113443030 hasConcept C148738053 @default.
• W2113443030 hasConcept C160160445 @default.
• W2113443030 hasConcept C17938293 @default.
• W2113443030 hasConcept C181199279 @default.
• W2113443030 hasConcept C185592680 @default.
• W2113443030 hasConcept C2776014264 @default.
• W2113443030 hasConcept C2776363554 @default.
• W2113443030 hasConcept C2780550940 @default.
• W2113443030 hasConcept C2781013607 @default.
• W2113443030 hasConcept C2781121885 @default.
• W2113443030 hasConcept C2781403057 @default.
• W2113443030 hasConcept C28328180 @default.
• W2113443030 hasConcept C35496256 @default.
• W2113443030 hasConcept C55493867 @default.
• W2113443030 hasConcept C71924100 @default.
• W2113443030 hasConcept C86803240 @default.
• W2113443030 hasConcept C95444343 @default.
• W2113443030 hasConceptScore W2113443030C104317684 @default.
• W2113443030 hasConceptScore W2113443030C105702510 @default.
• W2113443030 hasConceptScore W2113443030C126322002 @default.
• W2113443030 hasConceptScore W2113443030C134018914 @default.
• W2113443030 hasConceptScore W2113443030C148738053 @default.
• W2113443030 hasConceptScore W2113443030C160160445 @default.
• W2113443030 hasConceptScore W2113443030C17938293 @default.
• W2113443030 hasConceptScore W2113443030C181199279 @default.
• W2113443030 hasConceptScore W2113443030C185592680 @default.
• W2113443030 hasConceptScore W2113443030C2776014264 @default.
• W2113443030 hasConceptScore W2113443030C2776363554 @default.
• W2113443030 hasConceptScore W2113443030C2780550940 @default.
• W2113443030 hasConceptScore W2113443030C2781013607 @default.
• W2113443030 hasConceptScore W2113443030C2781121885 @default.
• W2113443030 hasConceptScore W2113443030C2781403057 @default.
• W2113443030 hasConceptScore W2113443030C28328180 @default.
• W2113443030 hasConceptScore W2113443030C35496256 @default.
• W2113443030 hasConceptScore W2113443030C55493867 @default.
• W2113443030 hasConceptScore W2113443030C71924100 @default.
• W2113443030 hasConceptScore W2113443030C86803240 @default.
• W2113443030 hasConceptScore W2113443030C95444343 @default.
• W2113443030 hasIssue "3" @default.
• W2113443030 hasLocation W21134430301 @default.
• W2113443030 hasOpenAccess W2113443030 @default.

• next