Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113444727> ?p ?o ?g. }
- W2113444727 endingPage "979" @default.
- W2113444727 startingPage "974" @default.
- W2113444727 abstract "Background Faecal calprotectin levels correlate with inflammation in inflammatory bowel disease. We evaluated the role of faecal calprotectin after anti-Tumour Necrosis Factor α induction in inflammatory bowel disease patients to predict therapeutic effect at one year. Methods Faecal calprotectin levels were measured in stools of 63 patients before and after induction of anti-Tumour Necrosis Factor α therapy. Clinical activity, measured by clinical indices, was assessed before and after biologic treatment. Clinical responders after induction were included in the study and colonoscopy was performed before and after one year of treatment to assess mucosal healing. Results 63 patients (44 Crohn's disease, 19 ulcerative colitis) were prospectively included (41.2% males, mean age at diagnosis 33 years). A sustained clinical response during the first year was observed in 57% of patients; median faecal calprotectin was 106 μg/g after induction versus 308 μg/g pre-induction (p < 0.0001). Post-induction faecal calprotectin was significantly lower in responders versus non-responders (p = 0.0002). Post-induction faecal calprotectin had 83% sensitivity and 74% specificity (cut-off ≤168 μg/g) for predicting a sustained clinical response at one year (p = 0.0001); also, sensitivity was 79% and specificity 57% (cut-off ≤121 μg/g) for predicting mucosal healing (p = 0.0001). Conclusions In inflammatory bowel disease faecal calprotectin assay after anti-Tumour Necrosis Factor α induction can be used as a marker to predict sustained clinical response and mucosal healing at one year." @default.
- W2113444727 created "2016-06-24" @default.
- W2113444727 creator A5003293386 @default.
- W2113444727 creator A5012764144 @default.
- W2113444727 creator A5031422334 @default.
- W2113444727 creator A5055386057 @default.
- W2113444727 creator A5057981035 @default.
- W2113444727 creator A5058934291 @default.
- W2113444727 creator A5060132638 @default.
- W2113444727 creator A5072798466 @default.
- W2113444727 creator A5080153483 @default.
- W2113444727 creator A5081171957 @default.
- W2113444727 creator A5084379983 @default.
- W2113444727 creator A5086837888 @default.
- W2113444727 date "2014-11-01" @default.
- W2113444727 modified "2023-09-26" @default.
- W2113444727 title "Faecal calprotectin assay after induction with anti-Tumour Necrosis Factor α agents in inflammatory bowel disease: Prediction of clinical response and mucosal healing at one year" @default.
- W2113444727 cites W134031355 @default.
- W2113444727 cites W1568563504 @default.
- W2113444727 cites W1752248076 @default.
- W2113444727 cites W1987064800 @default.
- W2113444727 cites W1990311132 @default.
- W2113444727 cites W2009446106 @default.
- W2113444727 cites W2028006265 @default.
- W2113444727 cites W2032206624 @default.
- W2113444727 cites W2036503241 @default.
- W2113444727 cites W2049194517 @default.
- W2113444727 cites W2054755479 @default.
- W2113444727 cites W2060254645 @default.
- W2113444727 cites W2061837689 @default.
- W2113444727 cites W2073851206 @default.
- W2113444727 cites W2077570588 @default.
- W2113444727 cites W2088874765 @default.
- W2113444727 cites W2089176308 @default.
- W2113444727 cites W2096308931 @default.
- W2113444727 cites W2112992146 @default.
- W2113444727 cites W2117749928 @default.
- W2113444727 cites W2158926558 @default.
- W2113444727 cites W2159561736 @default.
- W2113444727 cites W2160240762 @default.
- W2113444727 cites W2161661686 @default.
- W2113444727 cites W2166930089 @default.
- W2113444727 cites W2169962494 @default.
- W2113444727 cites W2171484002 @default.
- W2113444727 cites W2321205867 @default.
- W2113444727 doi "https://doi.org/10.1016/j.dld.2014.07.013" @default.
- W2113444727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25096964" @default.
- W2113444727 hasPublicationYear "2014" @default.
- W2113444727 type Work @default.
- W2113444727 sameAs 2113444727 @default.
- W2113444727 citedByCount "63" @default.
- W2113444727 countsByYear W21134447272014 @default.
- W2113444727 countsByYear W21134447272015 @default.
- W2113444727 countsByYear W21134447272016 @default.
- W2113444727 countsByYear W21134447272017 @default.
- W2113444727 countsByYear W21134447272018 @default.
- W2113444727 countsByYear W21134447272019 @default.
- W2113444727 countsByYear W21134447272020 @default.
- W2113444727 countsByYear W21134447272021 @default.
- W2113444727 countsByYear W21134447272022 @default.
- W2113444727 countsByYear W21134447272023 @default.
- W2113444727 crossrefType "journal-article" @default.
- W2113444727 hasAuthorship W2113444727A5003293386 @default.
- W2113444727 hasAuthorship W2113444727A5012764144 @default.
- W2113444727 hasAuthorship W2113444727A5031422334 @default.
- W2113444727 hasAuthorship W2113444727A5055386057 @default.
- W2113444727 hasAuthorship W2113444727A5057981035 @default.
- W2113444727 hasAuthorship W2113444727A5058934291 @default.
- W2113444727 hasAuthorship W2113444727A5060132638 @default.
- W2113444727 hasAuthorship W2113444727A5072798466 @default.
- W2113444727 hasAuthorship W2113444727A5080153483 @default.
- W2113444727 hasAuthorship W2113444727A5081171957 @default.
- W2113444727 hasAuthorship W2113444727A5084379983 @default.
- W2113444727 hasAuthorship W2113444727A5086837888 @default.
- W2113444727 hasConcept C121608353 @default.
- W2113444727 hasConcept C126322002 @default.
- W2113444727 hasConcept C17991360 @default.
- W2113444727 hasConcept C203014093 @default.
- W2113444727 hasConcept C2778260677 @default.
- W2113444727 hasConcept C2778292693 @default.
- W2113444727 hasConcept C2778435480 @default.
- W2113444727 hasConcept C2779008522 @default.
- W2113444727 hasConcept C2779134260 @default.
- W2113444727 hasConcept C2779280984 @default.
- W2113444727 hasConcept C2780479503 @default.
- W2113444727 hasConcept C503630168 @default.
- W2113444727 hasConcept C526805850 @default.
- W2113444727 hasConcept C71924100 @default.
- W2113444727 hasConcept C90924648 @default.
- W2113444727 hasConceptScore W2113444727C121608353 @default.
- W2113444727 hasConceptScore W2113444727C126322002 @default.
- W2113444727 hasConceptScore W2113444727C17991360 @default.
- W2113444727 hasConceptScore W2113444727C203014093 @default.
- W2113444727 hasConceptScore W2113444727C2778260677 @default.
- W2113444727 hasConceptScore W2113444727C2778292693 @default.
- W2113444727 hasConceptScore W2113444727C2778435480 @default.
- W2113444727 hasConceptScore W2113444727C2779008522 @default.
- W2113444727 hasConceptScore W2113444727C2779134260 @default.