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• W2113445079 abstract "Oxygenation-sensitive (OS) cardiovascular magnetic resonance (CMR) is used to noninvasively measure myocardial oxygenation changes during pharmacologic vasodilation. The use of breathing maneuvers with OS CMR for diagnostic purposes has been recently proposed based on the vasodilatory effect of Co2, which can be enhanced by the additive effect of mild hypoxia. This study seeks to investigate this synergistic concept on coronary arteriolar resistance with OS CMR. In nine anesthetized swine, normoxemic and mild hypoxemic arterial partial pressure of oxygen (Pao2) levels (100 and 80 mmHg) were targeted with three arterial partial pressure of carbon dioxide (Paco2) levels of 30, 40, and 50 mmHg. During a 60-sec apnea from the set baselines, OS T2*-weighted gradient echo steady-state free precession (SSFP) cine series were obtained in a clinical 1.5T magnetic resonance imaging (MRI) system. Arterial blood gases were acquired prior to and after apnea. Changes in global myocardial signal intensity (SI) were measured. Although a greater drop in arterial oxygen saturation (SaO2) was observed in the hypoxemic baselines, myocardial SI increased or was maintained during apnea in all levels (n = 6). An observed decrease in left ventricular blood pool SI was correlated with the drop in SaO2. Corrected for the arterial desaturation, the calculated SI increase attributable to the increase in myocardial blood flow was greater in the hypoxemic levels. Both the changes in Paco2 and Pao2 were correlated with myocardial SI changes at normoxemia, yet not at hypoxemic levels. Using OS CMR, we found evidence that myocardial oxygenation is preserved during hypoxia when combined with Co2-increasing maneuvers, indicating synergistic effects of hypoxemia and hypercapnia on myocardial blood flow." @default.
• W2113445079 created "2016-06-24" @default.
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• W2113445079 date "2013-10-01" @default.
• W2113445079 modified "2023-09-30" @default.
• W2113445079 title "Myocardial oxygenation is maintained during hypoxia when combined with apnea - a cardiovascular MR study" @default.
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• W2113445079 doi "https://doi.org/10.1002/phy2.98" @default.
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