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- W2113446474 abstract "<h2>Abstract</h2> The safety and efficacy of a sustained-release preparation of diftiazem (diltiazem-SR), with dose levels of 240 and 360 mg/day, were assessed In 18 patients with stable angina of effort. A double-blind, placebo-controlled, randomized, crossover protocol was used. Diltiazem-SR, when given twice daily, reduced the frequency of weekly anginal attacks from 9.3 ± 10.4 with placebo to 3.7 ± 4.7 with 240 mg/day and to 3.1 ± 4.7 with 360 mg/day (both p <0.01 compared with placebo). Treadmill time was increased from 410 ± 180 seconds during the placebo phase to 519 ± 177 seconds during the 240-mg/day dose and to 506 ± 182 seconds during the 360-mg/day dose of diflazem-SR (both p <0.01 compared with placebo). The time to the onset of angina and ischemic ST-segment depression were similarly prolonged by both doses of diltiazem-SR. The beneficial effects of diltiazem-SR appeared partly due to a reduction in the heart rate during submaximal exercise. Diltiazem-SR is effective and safe for the treatment of angina of effort when given twice daily." @default.
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- W2113446474 title "Efficacy and safety of sustained-release diltiazem in stable angina pectoris" @default.
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- W2113446474 doi "https://doi.org/10.1016/0002-9149(86)90941-0" @default.
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