FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113446876> ?p ?o ?g. }

• W2113446876 endingPage "2238" @default.
• W2113446876 startingPage "2238" @default.
• W2113446876 abstract "The synthesis, structure and cytotoxic activity of Pt(II), Pd(II) and Cu(II) complexes of the general formula MLCl2 (M = Pt, Pd, Cu) 2–4 and (CuLCl2)25 where L is pyrazole-based chelate ligand 3-methyl-1-(2-pyridinyl)-1H-chromene[4,3-c]pyrazol-4-one 1 are described. The complexes were characterized by elemental analysis, infrared and 1H NMR spectroscopy, as well as electrospray mass spectrometry. Compounds 3 and 5 were also studied using X-ray diffraction. In addition, geometries, partial atomic charges, and lipophilicity, which determines their ability to penetrate through cells membranes, were obtained computationally. Complexes 2–4 exhibit square-planar geometries around the metal(II) centers and adopt cis configuration. Complex 5 is a dimer with distorted tetragonal pyramidal configuration at both Cu(II) centers, which are connected by two μ2-chloro bridges in axial positions. The cytotoxic effect of these complexes was examined on HL-60 and NALM-6 human leukemia cells and melanoma WM-115 cells. The Pt-complex cis-2 exhibited moderate cytotoxic activity against leukemic cells, but relatively high activity toward melanoma cells with cytotoxicity of IC50 = 16.6 μM at a level comparable to that of cisplatin (18.2 μM)." @default.
• W2113446876 created "2016-06-24" @default.
• W2113446876 creator A5010784491 @default.
• W2113446876 creator A5015345189 @default.
• W2113446876 creator A5027575830 @default.
• W2113446876 creator A5028431206 @default.
• W2113446876 creator A5055001948 @default.
• W2113446876 creator A5075116802 @default.
• W2113446876 creator A5084458972 @default.
• W2113446876 creator A5091558424 @default.
• W2113446876 date "2008-01-01" @default.
• W2113446876 modified "2023-10-11" @default.
• W2113446876 title "Synthesis, crystal structure, theoretical calculation and cytotoxic effect of new Pt(ii), Pd(ii) and Cu(ii) complexes with pyridine-pyrazoles derivatives" @default.
• W2113446876 cites W1650728208 @default.
• W2113446876 cites W1966290397 @default.
• W2113446876 cites W1969635440 @default.
• W2113446876 cites W1993383767 @default.
• W2113446876 cites W1997218960 @default.
• W2113446876 cites W1997613954 @default.
• W2113446876 cites W2020737393 @default.
• W2113446876 cites W2032313197 @default.
• W2113446876 cites W2034930579 @default.
• W2113446876 cites W2046054562 @default.
• W2113446876 cites W2055147368 @default.
• W2113446876 cites W2068055518 @default.
• W2113446876 cites W2068617439 @default.
• W2113446876 cites W2075042822 @default.
• W2113446876 cites W2076311789 @default.
• W2113446876 cites W2077140040 @default.
• W2113446876 cites W2078111434 @default.
• W2113446876 cites W2082917109 @default.
• W2113446876 cites W2090894644 @default.
• W2113446876 cites W2093642381 @default.
• W2113446876 cites W2102537419 @default.
• W2113446876 cites W2114754788 @default.
• W2113446876 cites W2125529404 @default.
• W2113446876 cites W2167170179 @default.
• W2113446876 cites W2952208552 @default.
• W2113446876 doi "https://doi.org/10.1039/b808301k" @default.
• W2113446876 hasPublicationYear "2008" @default.
• W2113446876 type Work @default.
• W2113446876 sameAs 2113446876 @default.
• W2113446876 citedByCount "22" @default.
• W2113446876 countsByYear W21134468762012 @default.
• W2113446876 countsByYear W21134468762013 @default.
• W2113446876 countsByYear W21134468762014 @default.
• W2113446876 countsByYear W21134468762017 @default.
• W2113446876 countsByYear W21134468762018 @default.
• W2113446876 countsByYear W21134468762019 @default.
• W2113446876 countsByYear W21134468762020 @default.
• W2113446876 countsByYear W21134468762021 @default.
• W2113446876 countsByYear W21134468762023 @default.
• W2113446876 crossrefType "journal-article" @default.
• W2113446876 hasAuthorship W2113446876A5010784491 @default.
• W2113446876 hasAuthorship W2113446876A5015345189 @default.
• W2113446876 hasAuthorship W2113446876A5027575830 @default.
• W2113446876 hasAuthorship W2113446876A5028431206 @default.
• W2113446876 hasAuthorship W2113446876A5055001948 @default.
• W2113446876 hasAuthorship W2113446876A5075116802 @default.
• W2113446876 hasAuthorship W2113446876A5084458972 @default.
• W2113446876 hasAuthorship W2113446876A5091558424 @default.
• W2113446876 hasConcept C109316439 @default.
• W2113446876 hasConcept C115624301 @default.
• W2113446876 hasConcept C116569031 @default.
• W2113446876 hasConcept C154317977 @default.
• W2113446876 hasConcept C155647269 @default.
• W2113446876 hasConcept C161790260 @default.
• W2113446876 hasConcept C170493617 @default.
• W2113446876 hasConcept C170751736 @default.
• W2113446876 hasConcept C178790620 @default.
• W2113446876 hasConcept C185592680 @default.
• W2113446876 hasConcept C201399114 @default.
• W2113446876 hasConcept C202751555 @default.
• W2113446876 hasConcept C2777682936 @default.
• W2113446876 hasConcept C2779485729 @default.
• W2113446876 hasConcept C2779546866 @default.
• W2113446876 hasConcept C518104683 @default.
• W2113446876 hasConcept C544153396 @default.
• W2113446876 hasConcept C55493867 @default.
• W2113446876 hasConcept C71240020 @default.
• W2113446876 hasConcept C8010536 @default.
• W2113446876 hasConceptScore W2113446876C109316439 @default.
• W2113446876 hasConceptScore W2113446876C115624301 @default.
• W2113446876 hasConceptScore W2113446876C116569031 @default.
• W2113446876 hasConceptScore W2113446876C154317977 @default.
• W2113446876 hasConceptScore W2113446876C155647269 @default.
• W2113446876 hasConceptScore W2113446876C161790260 @default.
• W2113446876 hasConceptScore W2113446876C170493617 @default.
• W2113446876 hasConceptScore W2113446876C170751736 @default.
• W2113446876 hasConceptScore W2113446876C178790620 @default.
• W2113446876 hasConceptScore W2113446876C185592680 @default.
• W2113446876 hasConceptScore W2113446876C201399114 @default.
• W2113446876 hasConceptScore W2113446876C202751555 @default.
• W2113446876 hasConceptScore W2113446876C2777682936 @default.
• W2113446876 hasConceptScore W2113446876C2779485729 @default.
• W2113446876 hasConceptScore W2113446876C2779546866 @default.
• W2113446876 hasConceptScore W2113446876C518104683 @default.
• W2113446876 hasConceptScore W2113446876C544153396 @default.

• next