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• W2113448488 endingPage "1927" @default.
• W2113448488 startingPage "1918" @default.
• W2113448488 abstract "The gonococcal pilus is a primary virulence factor, providing the initial attachment of the bacterial cell to human mucosal tissues. Pilin, the major subunit of the pilus, can carry a wide spectrum of primary amino acid sequences which are generated by the action of a complex antigenic variation system. Changes in the pilin amino acid sequence can produce different pilus-dependent colony morphotypes, which have been previously shown to reflect phase variation of pili on the bacterial cell surface. In this study, we further examined the relationships between changes in pilus-dependent colony morphology, pilin sequence, pilus expression, and pilus function in Neisseria gonorrhoeae FA1090. A group of FA1090 colony variants expressed different pilin sequences and demonstrated different levels of pilin, S-pilin, and pilus expression. The analysis of these colony variants shows that they do not represent two distinct phases of pilus expression, but that changes in pilin protein sequence produce a spectrum of S-pilin production, pilus expression, and pilus aggregation levels. These different levels of pilus expression and aggregation influence not only colony morphology but also DNA transformation efficiency and epithelial cell adherence." @default.
• W2113448488 created "2016-06-24" @default.
• W2113448488 creator A5009098287 @default.
• W2113448488 creator A5029543804 @default.
• W2113448488 creator A5038116641 @default.
• W2113448488 date "1998-05-01" @default.
• W2113448488 modified "2023-10-01" @default.
• W2113448488 title "Comparisons between Colony Phase Variation of <i>Neisseria gonorrhoeae</i> FA1090 and Pilus, Pilin, and S-Pilin Expression" @default.
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• W2113448488 doi "https://doi.org/10.1128/iai.66.5.1918-1927.1998" @default.
• W2113448488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/108144" @default.
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• W2113448488 hasPublicationYear "1998" @default.
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