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- W2113448947 abstract "Abstract Thymic T cell production is characterized by differentiating waves of non-self-renewing, bone marrow-derived progenitors. The factors constraining new progenitor recruitment, intrathymic precursor expansion, and thymus size remain enigmatic, but are believed to be controlled by a feedback loop responding to lymphoid cellularity and competition for stromal niches. In this study, we show that competition for stromal niches does occur, but is solely limited to cells at the early CD4−8− precursor stages of differentiation. The overall size of the organ is determined both by this limitation on early precursor expansion, and by a second, cell-intrinsic limit on expansion of progenitor cells transiting to the CD4+8+ stage. Together with asymmetric use of marrow-derived progenitors to reconstitute the intrathymic pool, these processes facilitate continuous generation of new T cells while maintaining a relatively stable organ size." @default.
- W2113448947 created "2016-06-24" @default.
- W2113448947 creator A5052956899 @default.
- W2113448947 creator A5060906149 @default.
- W2113448947 date "2004-08-01" @default.
- W2113448947 modified "2023-10-18" @default.
- W2113448947 title "Regulation of Thymus Size by Competition for Stromal Niches among Early T Cell Progenitors" @default.
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- W2113448947 doi "https://doi.org/10.4049/jimmunol.173.3.1604" @default.
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