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• W2113449039 endingPage "825" @default.
• W2113449039 startingPage "813" @default.
• W2113449039 abstract "Left ventricular non-compaction, the most recently classified form of cardiomyopathy, is characterised by abnormal trabeculations in the left ventricle, most frequently at the apex. It can be associated with left ventricular dilation or hypertrophy, systolic or diastolic dysfunction, or both, or various forms of congenital heart disease. Affected individuals are at risk of left or right ventricular failure, or both. Heart failure symptoms can be induced by exercise or be persistent at rest, but many patients are asymptomatic. Patients on chronic treatment for compensated heart failure sometimes present acutely with decompensated heart failure. Other life-threatening risks of left ventricular non-compaction are ventricular arrhythmias or complete atrioventricular block, presenting clinically as syncope, and sudden death. Genetic inheritance arises in at least 30-50% of patients, and several genes that cause left ventricular non-compaction have been identified. These genes seem generally to encode sarcomeric (contractile apparatus) or cytoskeletal proteins, although, in the case of left ventricular non-compaction with congenital heart disease, disturbance of the NOTCH signalling pathway seems part of a final common pathway for this form of the disease. Disrupted mitochondrial function and metabolic abnormalities have a causal role too. Treatments focus on improvement of cardiac efficiency and reduction of mechanical stress in patients with systolic dysfunction. Further, treatment of arrhythmia and implantation of an automatic implantable cardioverter-defibrillator for prevention of sudden death are mainstays of therapy when deemed necessary and appropriate. Patients with left ventricular non-compaction and congenital heart disease often need surgical or catheter-based interventions. Despite progress in diagnosis and treatment in the past 10 years, understanding of the disorder and outcomes need to be improved." @default.
• W2113449039 created "2016-06-24" @default.
• W2113449039 creator A5013335511 @default.
• W2113449039 creator A5070095313 @default.
• W2113449039 creator A5090814913 @default.
• W2113449039 date "2015-08-01" @default.
• W2113449039 modified "2023-10-13" @default.
• W2113449039 title "Left ventricular non-compaction cardiomyopathy" @default.
• W2113449039 cites W145908001 @default.
• W2113449039 cites W1497069919 @default.
• W2113449039 cites W1505699942 @default.
• W2113449039 cites W1522775437 @default.
• W2113449039 cites W154631126 @default.
• W2113449039 cites W1585469648 @default.
• W2113449039 cites W1606727311 @default.
• W2113449039 cites W1663371441 @default.
• W2113449039 cites W1760771044 @default.
• W2113449039 cites W183973455 @default.
• W2113449039 cites W1887637739 @default.
• W2113449039 cites W1891888420 @default.
• W2113449039 cites W1892390853 @default.
• W2113449039 cites W1965454062 @default.
• W2113449039 cites W1969454506 @default.
• W2113449039 cites W1969937201 @default.
• W2113449039 cites W1971336237 @default.
• W2113449039 cites W1972802956 @default.
• W2113449039 cites W1973706332 @default.
• W2113449039 cites W1975906137 @default.
• W2113449039 cites W1976326756 @default.
• W2113449039 cites W1976646890 @default.
• W2113449039 cites W1984754431 @default.
• W2113449039 cites W1986624703 @default.
• W2113449039 cites W1987477340 @default.
• W2113449039 cites W1987755204 @default.
• W2113449039 cites W1988058643 @default.
• W2113449039 cites W1989713686 @default.
• W2113449039 cites W1992882945 @default.
• W2113449039 cites W1994698599 @default.
• W2113449039 cites W2000266640 @default.
• W2113449039 cites W2002583490 @default.
• W2113449039 cites W2002970726 @default.
• W2113449039 cites W2003311702 @default.
• W2113449039 cites W2008864463 @default.
• W2113449039 cites W2009691901 @default.
• W2113449039 cites W2014346447 @default.
• W2113449039 cites W2015031360 @default.
• W2113449039 cites W2016368778 @default.
• W2113449039 cites W2016432558 @default.
• W2113449039 cites W2016742419 @default.
• W2113449039 cites W2016786206 @default.
• W2113449039 cites W2017031270 @default.
• W2113449039 cites W2017923546 @default.
• W2113449039 cites W2019544101 @default.
• W2113449039 cites W2021748421 @default.
• W2113449039 cites W2023239650 @default.
• W2113449039 cites W2028330033 @default.
• W2113449039 cites W2029142164 @default.
• W2113449039 cites W2031144123 @default.
• W2113449039 cites W2032638158 @default.
• W2113449039 cites W2035665934 @default.
• W2113449039 cites W2036807516 @default.
• W2113449039 cites W2039442296 @default.
• W2113449039 cites W2039787319 @default.
• W2113449039 cites W2040003771 @default.
• W2113449039 cites W2043474023 @default.
• W2113449039 cites W2047106546 @default.
• W2113449039 cites W2048260015 @default.
• W2113449039 cites W2049074704 @default.
• W2113449039 cites W2053426660 @default.
• W2113449039 cites W2057745539 @default.
• W2113449039 cites W2060961033 @default.
• W2113449039 cites W2063786230 @default.
• W2113449039 cites W2064259166 @default.
• W2113449039 cites W2064875781 @default.
• W2113449039 cites W2065888309 @default.
• W2113449039 cites W2066843469 @default.
• W2113449039 cites W2066888615 @default.
• W2113449039 cites W2068157186 @default.
• W2113449039 cites W2071034043 @default.
• W2113449039 cites W2075168548 @default.
• W2113449039 cites W2075651430 @default.
• W2113449039 cites W2078526676 @default.
• W2113449039 cites W2083564848 @default.
• W2113449039 cites W2084688599 @default.
• W2113449039 cites W2086405883 @default.
• W2113449039 cites W2089451640 @default.
• W2113449039 cites W2089814937 @default.
• W2113449039 cites W2090304791 @default.
• W2113449039 cites W2093498435 @default.
• W2113449039 cites W2094917724 @default.
• W2113449039 cites W2096511545 @default.
• W2113449039 cites W2097370116 @default.
• W2113449039 cites W2097751477 @default.
• W2113449039 cites W2101641299 @default.
• W2113449039 cites W2103031848 @default.
• W2113449039 cites W2111134301 @default.
• W2113449039 cites W2111336754 @default.
• W2113449039 cites W2112407636 @default.

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