Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113451643> ?p ?o ?g. }
- W2113451643 endingPage "987" @default.
- W2113451643 startingPage "978" @default.
- W2113451643 abstract "A segregating F(2) pedigree based on two mouse lines (DU6i and DBA/2) with extremely different growth characteristics was generated to search for loci affecting serum levels of insulin-like growth factor (IGF) binding proteins (IGFBPs) and to estimate their effects on growth and body composition. DU6i is characterized by high body mass and obesity associated with hyperinsulinemia, hyperleptinemia, and elevated serum IGF-I concentrations. Furthermore, significantly elevated serum levels of IGFBP-2, IGFBP-3, and IGFBP-4 were found in DU6i vs. DBA/2 mice. Linkage analysis identified loci with major effects on the serum level of IGFBP-3 on Chromosome 5 at 58 cM (Igfbp3q1; F = 9.9) and on Chromosome 10 at 46 cM (Igfbp3q2; F = 33.8). A locus significantly influencing serum IGFBP-2 levels in males was found on Chromosome 7. Additional linkage was detected in males and females for IGFBP-2 on Chromosomes 8, 11, 14, 17, and X, and for IGFBP-4 on Chromosome 4. Additional loci affecting IGFBPs acted in a sex-specific manner. The identified loci coincide in part with chromosomal regions controlling growth and obesity. Thus, multiple genes or pleiotropic gene effects may be assumed for these chromosomal regions. The identification of quantitative trait loci for IGFBPs as subcomponents of growth regulation and differentiation will further improve the understanding of complex trait regulation." @default.
- W2113451643 created "2016-06-24" @default.
- W2113451643 creator A5006934895 @default.
- W2113451643 creator A5023253476 @default.
- W2113451643 creator A5024292257 @default.
- W2113451643 creator A5042742414 @default.
- W2113451643 creator A5059436450 @default.
- W2113451643 creator A5060090222 @default.
- W2113451643 creator A5060679716 @default.
- W2113451643 creator A5081222111 @default.
- W2113451643 date "2001-04-01" @default.
- W2113451643 modified "2023-10-03" @default.
- W2113451643 title "Genome-wide search for loci controlling serum IGF binding protein levels of mice" @default.
- W2113451643 cites W1600880434 @default.
- W2113451643 cites W1967184988 @default.
- W2113451643 cites W1972819401 @default.
- W2113451643 cites W1976234954 @default.
- W2113451643 cites W1976741643 @default.
- W2113451643 cites W1978538634 @default.
- W2113451643 cites W1991011471 @default.
- W2113451643 cites W1993485714 @default.
- W2113451643 cites W1993672117 @default.
- W2113451643 cites W1998158007 @default.
- W2113451643 cites W2007006137 @default.
- W2113451643 cites W2008787085 @default.
- W2113451643 cites W2017949036 @default.
- W2113451643 cites W2018690794 @default.
- W2113451643 cites W2027454234 @default.
- W2113451643 cites W2033373879 @default.
- W2113451643 cites W2042383730 @default.
- W2113451643 cites W2042563911 @default.
- W2113451643 cites W2049777033 @default.
- W2113451643 cites W2051192888 @default.
- W2113451643 cites W2060209614 @default.
- W2113451643 cites W2062393711 @default.
- W2113451643 cites W2064731204 @default.
- W2113451643 cites W2069408076 @default.
- W2113451643 cites W2084537045 @default.
- W2113451643 cites W2091733793 @default.
- W2113451643 cites W2093060079 @default.
- W2113451643 cites W2096201493 @default.
- W2113451643 cites W2114895846 @default.
- W2113451643 cites W2115073960 @default.
- W2113451643 cites W2121157101 @default.
- W2113451643 cites W2122720918 @default.
- W2113451643 cites W2125860227 @default.
- W2113451643 cites W2128977956 @default.
- W2113451643 cites W2136314815 @default.
- W2113451643 cites W2137349730 @default.
- W2113451643 cites W2141953208 @default.
- W2113451643 cites W2152992515 @default.
- W2113451643 cites W2157109399 @default.
- W2113451643 cites W2333065574 @default.
- W2113451643 cites W2415446747 @default.
- W2113451643 cites W4242280461 @default.
- W2113451643 cites W4251337578 @default.
- W2113451643 doi "https://doi.org/10.1096/fj.00-0391com" @default.
- W2113451643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11292658" @default.
- W2113451643 hasPublicationYear "2001" @default.
- W2113451643 type Work @default.
- W2113451643 sameAs 2113451643 @default.
- W2113451643 citedByCount "15" @default.
- W2113451643 countsByYear W21134516432012 @default.
- W2113451643 countsByYear W21134516432013 @default.
- W2113451643 crossrefType "journal-article" @default.
- W2113451643 hasAuthorship W2113451643A5006934895 @default.
- W2113451643 hasAuthorship W2113451643A5023253476 @default.
- W2113451643 hasAuthorship W2113451643A5024292257 @default.
- W2113451643 hasAuthorship W2113451643A5042742414 @default.
- W2113451643 hasAuthorship W2113451643A5059436450 @default.
- W2113451643 hasAuthorship W2113451643A5060090222 @default.
- W2113451643 hasAuthorship W2113451643A5060679716 @default.
- W2113451643 hasAuthorship W2113451643A5081222111 @default.
- W2113451643 hasConcept C104317684 @default.
- W2113451643 hasConcept C134018914 @default.
- W2113451643 hasConcept C142870003 @default.
- W2113451643 hasConcept C170493617 @default.
- W2113451643 hasConcept C2775960820 @default.
- W2113451643 hasConcept C2777391703 @default.
- W2113451643 hasConcept C2780378035 @default.
- W2113451643 hasConcept C2780689927 @default.
- W2113451643 hasConcept C2780988686 @default.
- W2113451643 hasConcept C30481170 @default.
- W2113451643 hasConcept C511355011 @default.
- W2113451643 hasConcept C54355233 @default.
- W2113451643 hasConcept C81941488 @default.
- W2113451643 hasConcept C84597430 @default.
- W2113451643 hasConcept C86803240 @default.
- W2113451643 hasConceptScore W2113451643C104317684 @default.
- W2113451643 hasConceptScore W2113451643C134018914 @default.
- W2113451643 hasConceptScore W2113451643C142870003 @default.
- W2113451643 hasConceptScore W2113451643C170493617 @default.
- W2113451643 hasConceptScore W2113451643C2775960820 @default.
- W2113451643 hasConceptScore W2113451643C2777391703 @default.
- W2113451643 hasConceptScore W2113451643C2780378035 @default.
- W2113451643 hasConceptScore W2113451643C2780689927 @default.
- W2113451643 hasConceptScore W2113451643C2780988686 @default.
- W2113451643 hasConceptScore W2113451643C30481170 @default.