FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113452202> ?p ?o ?g. }

• W2113452202 endingPage "987" @default.
• W2113452202 startingPage "979" @default.
• W2113452202 abstract "The pathways that allow short noncoding RNAs such as the microRNAs (miRNAs) to mediate gene regulation and control critical cellular and developmental processes involve a limited number of key protein components. These proteins are the Dicer-like RNases, double-stranded RNA (dsRNA)-binding proteins, and the Argonaute (AGO) proteins that process stem-loop hairpin transcripts of endogenous genes to generate miRNAs or long dsRNA precursors (either exogenous or endogenous). Comparative genomics studies of metazoans have shown the pathways to be highly conserved overall; the major difference observed is that the vertebrate pathways overlap in sharing a single Dicer (DCR) and AGO proteins, whereas those of insects appear to be parallel, with distinct Dicers and AGOs required for each pathway. The genome of the pea aphid is the first available for a hemipteran insect and discloses an unexpected expansion of the miRNA pathway. It has two copies of the miRNA-specific dicr-1 and ago1 genes and four copies of pasha a cofactor of drosha involved in miRNA biosynthesis. For three of these expansions, we showed that one copy of the genes diverged rapidly and in one case (ago1b) shows signs of positive selection. These expansions occurred concomitantly within a brief evolutionary period. The pea aphid, which reproduces by viviparous parthenogenesis, is able to produce several adapted phenotypes from one single genotype. We show by reverse transcriptase-polymerase chain reaction that all the duplicated copies of the miRNA machinery genes are expressed in the different morphs. Investigating the function of these novel genes offers an exciting new challenge in aphid biology." @default.
• W2113452202 created "2016-06-24" @default.
• W2113452202 creator A5005611851 @default.
• W2113452202 creator A5010182938 @default.
• W2113452202 creator A5014840793 @default.
• W2113452202 creator A5015072206 @default.
• W2113452202 creator A5028159018 @default.
• W2113452202 creator A5032323887 @default.
• W2113452202 creator A5074945252 @default.
• W2113452202 date "2010-02-23" @default.
• W2113452202 modified "2023-10-13" @default.
• W2113452202 title "Expansion of the miRNA Pathway in the Hemipteran Insect Acyrthosiphon pisum" @default.
• W2113452202 cites W1972649540 @default.
• W2113452202 cites W1977937947 @default.
• W2113452202 cites W1989454102 @default.
• W2113452202 cites W2004271888 @default.
• W2113452202 cites W2008273315 @default.
• W2113452202 cites W2025484566 @default.
• W2113452202 cites W2027891004 @default.
• W2113452202 cites W2033518550 @default.
• W2113452202 cites W2034255392 @default.
• W2113452202 cites W2041791287 @default.
• W2113452202 cites W2043251062 @default.
• W2113452202 cites W2043254922 @default.
• W2113452202 cites W2046109186 @default.
• W2113452202 cites W2046905215 @default.
• W2113452202 cites W2057558367 @default.
• W2113452202 cites W2061328240 @default.
• W2113452202 cites W2066213138 @default.
• W2113452202 cites W2073718731 @default.
• W2113452202 cites W2081858203 @default.
• W2113452202 cites W2082928585 @default.
• W2113452202 cites W2094177946 @default.
• W2113452202 cites W2096246936 @default.
• W2113452202 cites W2097233732 @default.
• W2113452202 cites W2103546861 @default.
• W2113452202 cites W2107961632 @default.
• W2113452202 cites W2116423958 @default.
• W2113452202 cites W2119015197 @default.
• W2113452202 cites W2119632499 @default.
• W2113452202 cites W2124791602 @default.
• W2113452202 cites W2136991248 @default.
• W2113452202 cites W2137519022 @default.
• W2113452202 cites W2138708625 @default.
• W2113452202 cites W2146396346 @default.
• W2113452202 cites W2147154770 @default.
• W2113452202 cites W2167833700 @default.
• W2113452202 cites W4210323379 @default.
• W2113452202 cites W4241303123 @default.
• W2113452202 doi "https://doi.org/10.1093/molbev/msp256" @default.
• W2113452202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2857804" @default.
• W2113452202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20179251" @default.
• W2113452202 hasPublicationYear "2010" @default.
• W2113452202 type Work @default.
• W2113452202 sameAs 2113452202 @default.
• W2113452202 citedByCount "56" @default.
• W2113452202 countsByYear W21134522022012 @default.
• W2113452202 countsByYear W21134522022013 @default.
• W2113452202 countsByYear W21134522022014 @default.
• W2113452202 countsByYear W21134522022015 @default.
• W2113452202 countsByYear W21134522022016 @default.
• W2113452202 countsByYear W21134522022017 @default.
• W2113452202 countsByYear W21134522022018 @default.
• W2113452202 countsByYear W21134522022019 @default.
• W2113452202 countsByYear W21134522022020 @default.
• W2113452202 countsByYear W21134522022021 @default.
• W2113452202 countsByYear W21134522022022 @default.
• W2113452202 countsByYear W21134522022023 @default.
• W2113452202 crossrefType "journal-article" @default.
• W2113452202 hasAuthorship W2113452202A5005611851 @default.
• W2113452202 hasAuthorship W2113452202A5010182938 @default.
• W2113452202 hasAuthorship W2113452202A5014840793 @default.
• W2113452202 hasAuthorship W2113452202A5015072206 @default.
• W2113452202 hasAuthorship W2113452202A5028159018 @default.
• W2113452202 hasAuthorship W2113452202A5032323887 @default.
• W2113452202 hasAuthorship W2113452202A5074945252 @default.
• W2113452202 hasBestOaLocation W21134522021 @default.
• W2113452202 hasConcept C104317684 @default.
• W2113452202 hasConcept C119056186 @default.
• W2113452202 hasConcept C141231307 @default.
• W2113452202 hasConcept C145059251 @default.
• W2113452202 hasConcept C166703698 @default.
• W2113452202 hasConcept C201853390 @default.
• W2113452202 hasConcept C22508944 @default.
• W2113452202 hasConcept C2776385806 @default.
• W2113452202 hasConcept C2776802755 @default.
• W2113452202 hasConcept C2776988988 @default.
• W2113452202 hasConcept C2779867133 @default.
• W2113452202 hasConcept C2781350953 @default.
• W2113452202 hasConcept C54355233 @default.
• W2113452202 hasConcept C59822182 @default.
• W2113452202 hasConcept C67705224 @default.
• W2113452202 hasConcept C86803240 @default.
• W2113452202 hasConceptScore W2113452202C104317684 @default.
• W2113452202 hasConceptScore W2113452202C119056186 @default.
• W2113452202 hasConceptScore W2113452202C141231307 @default.
• W2113452202 hasConceptScore W2113452202C145059251 @default.
• W2113452202 hasConceptScore W2113452202C166703698 @default.

• next