Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113452821> ?p ?o ?g. }
- W2113452821 endingPage "2379" @default.
- W2113452821 startingPage "2365" @default.
- W2113452821 abstract "A high-resolution crystal structure of KvAP, an archeabacterial voltage-gated potassium (Kv) channel, complexed with a monoclonal Fab fragment has been recently determined. Based on this structure, a mechanism for the activation (opening) of Kv channels has been put forward. This mechanism has since been criticized, suggesting that the resolved structure is not representative of the family of voltage-gated potassium channels. Here, we propose a model of the transmembrane domain of Shaker B, a well-characterized Kv channel, built by homology modeling and docking calculations. In this model, the positively charged S4 helices are oriented perpendicular to the membrane and localized in the groove between segments S5 and S6 of adjacent subunits. The structure and the dynamics of the full atomistic model embedded in a hydrated lipid bilayer were investigated by means of two large-scale molecular dynamics simulations under transmembrane-voltage conditions known to induce, respectively, the resting state (closed) and the activation (opening) of voltage-gated channels. Upon activation, the model undergoes conformational changes that lead to an increase of the hydration of the charged S4 helices, correlated with an upward translation and a tilting of the latter, concurrently with movements of the S5 helices and the activation gate. Although small, these conformational changes ultimately result in an alteration of the ion-conduction pathway. Our findings support the transporter model devised by Bezanilla and collaborators, and further underline the crucial role played by internal hydration in the activation of the channel." @default.
- W2113452821 created "2016-06-24" @default.
- W2113452821 creator A5012712063 @default.
- W2113452821 creator A5032070347 @default.
- W2113452821 creator A5037019808 @default.
- W2113452821 creator A5076283101 @default.
- W2113452821 date "2004-10-01" @default.
- W2113452821 modified "2023-10-18" @default.
- W2113452821 title "Coupled Motions between Pore and Voltage-Sensor Domains: A Model for Shaker B, a Voltage-Gated Potassium Channel" @default.
- W2113452821 cites W137649248 @default.
- W2113452821 cites W1517714742 @default.
- W2113452821 cites W1521070354 @default.
- W2113452821 cites W1524412093 @default.
- W2113452821 cites W1533488243 @default.
- W2113452821 cites W1643706501 @default.
- W2113452821 cites W1967026610 @default.
- W2113452821 cites W1970264142 @default.
- W2113452821 cites W1974672405 @default.
- W2113452821 cites W1976499671 @default.
- W2113452821 cites W1978192140 @default.
- W2113452821 cites W1980252678 @default.
- W2113452821 cites W1982505565 @default.
- W2113452821 cites W1984390370 @default.
- W2113452821 cites W1985490018 @default.
- W2113452821 cites W1985940938 @default.
- W2113452821 cites W1987923110 @default.
- W2113452821 cites W1993200959 @default.
- W2113452821 cites W1994727754 @default.
- W2113452821 cites W2000756554 @default.
- W2113452821 cites W2001634432 @default.
- W2113452821 cites W2005442221 @default.
- W2113452821 cites W2008470626 @default.
- W2113452821 cites W2010931500 @default.
- W2113452821 cites W2014226560 @default.
- W2113452821 cites W2015110061 @default.
- W2113452821 cites W2018088285 @default.
- W2113452821 cites W2020882032 @default.
- W2113452821 cites W2025173962 @default.
- W2113452821 cites W2025901527 @default.
- W2113452821 cites W2026582002 @default.
- W2113452821 cites W2027343672 @default.
- W2113452821 cites W2027408247 @default.
- W2113452821 cites W2027711565 @default.
- W2113452821 cites W2030125206 @default.
- W2113452821 cites W2031430636 @default.
- W2113452821 cites W2032734987 @default.
- W2113452821 cites W2034767282 @default.
- W2113452821 cites W2035066043 @default.
- W2113452821 cites W2038126340 @default.
- W2113452821 cites W2038141923 @default.
- W2113452821 cites W2041836266 @default.
- W2113452821 cites W2042590680 @default.
- W2113452821 cites W2043080340 @default.
- W2113452821 cites W2044341713 @default.
- W2113452821 cites W2053126924 @default.
- W2113452821 cites W2053413578 @default.
- W2113452821 cites W2056012239 @default.
- W2113452821 cites W2056776817 @default.
- W2113452821 cites W2058625742 @default.
- W2113452821 cites W2058779589 @default.
- W2113452821 cites W2060108293 @default.
- W2113452821 cites W2061059141 @default.
- W2113452821 cites W2062545099 @default.
- W2113452821 cites W2062567139 @default.
- W2113452821 cites W2063573925 @default.
- W2113452821 cites W2065197175 @default.
- W2113452821 cites W2065246613 @default.
- W2113452821 cites W2067174909 @default.
- W2113452821 cites W2073841786 @default.
- W2113452821 cites W2075520680 @default.
- W2113452821 cites W2082668900 @default.
- W2113452821 cites W2084137175 @default.
- W2113452821 cites W2087122819 @default.
- W2113452821 cites W2089735952 @default.
- W2113452821 cites W2090091933 @default.
- W2113452821 cites W2091356227 @default.
- W2113452821 cites W2094817280 @default.
- W2113452821 cites W2095134060 @default.
- W2113452821 cites W2100933640 @default.
- W2113452821 cites W2102431079 @default.
- W2113452821 cites W2103815459 @default.
- W2113452821 cites W2106207499 @default.
- W2113452821 cites W2106670341 @default.
- W2113452821 cites W2110170443 @default.
- W2113452821 cites W2111208593 @default.
- W2113452821 cites W2111436711 @default.
- W2113452821 cites W2112967619 @default.
- W2113452821 cites W2132589721 @default.
- W2113452821 cites W2132709044 @default.
- W2113452821 cites W2139852988 @default.
- W2113452821 cites W2141920771 @default.
- W2113452821 cites W2143070723 @default.
- W2113452821 cites W2145757534 @default.
- W2113452821 cites W2146906572 @default.
- W2113452821 cites W2152770371 @default.
- W2113452821 cites W2155979828 @default.
- W2113452821 cites W2158906453 @default.
- W2113452821 cites W2160451368 @default.