Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113453462> ?p ?o ?g. }
- W2113453462 endingPage "839" @default.
- W2113453462 startingPage "829" @default.
- W2113453462 abstract "A chemicogenetic screen was performed in budding yeast mutants that have a weakened replication stress response. This identified an inhibitor of target of rapamycin (TOR) complexes 1 and 2 that selectively enhances the sensitivity of sgs1Δ cells to hydroxyurea and camptothecin. More importantly, the inhibitor has strong synthetic lethality in combination with either the break-inducing antibiotic Zeocin or ionizing radiation, independent of the strain background. Lethality correlates with a rapid fragmentation of chromosomes that occurs only when TORC2, but not TORC1, is repressed. Genetic inhibition of Tor2 kinase, or its downstream effector kinases Ypk1/Ypk2, conferred similar synergistic effects in the presence of Zeocin. Given that Ypk1/Ypk2 controls the actin cytoskeleton, we tested the effects of actin modulators latrunculin A and jasplakinolide. These phenocopy TORC2 inhibition on Zeocin, although modulation of calcineurin-sensitive transcription does not. These results implicate TORC2-mediated actin filament regulation in the survival of low levels of DNA damage." @default.
- W2113453462 created "2016-06-24" @default.
- W2113453462 creator A5003312879 @default.
- W2113453462 creator A5007305472 @default.
- W2113453462 creator A5035434845 @default.
- W2113453462 creator A5037403931 @default.
- W2113453462 creator A5046222147 @default.
- W2113453462 creator A5051499117 @default.
- W2113453462 creator A5053457830 @default.
- W2113453462 creator A5077900527 @default.
- W2113453462 creator A5082924650 @default.
- W2113453462 creator A5089399852 @default.
- W2113453462 date "2013-09-01" @default.
- W2113453462 modified "2023-10-12" @default.
- W2113453462 title "TORC2 Signaling Pathway Guarantees Genome Stability in the Face of DNA Strand Breaks" @default.
- W2113453462 cites W1560179018 @default.
- W2113453462 cites W1627029737 @default.
- W2113453462 cites W1934941689 @default.
- W2113453462 cites W1967232610 @default.
- W2113453462 cites W1967487834 @default.
- W2113453462 cites W1969896771 @default.
- W2113453462 cites W1972718290 @default.
- W2113453462 cites W1974619322 @default.
- W2113453462 cites W1979246102 @default.
- W2113453462 cites W1984949624 @default.
- W2113453462 cites W2005188492 @default.
- W2113453462 cites W2014031830 @default.
- W2113453462 cites W2016630209 @default.
- W2113453462 cites W2016747889 @default.
- W2113453462 cites W2019215631 @default.
- W2113453462 cites W2021327083 @default.
- W2113453462 cites W2023620387 @default.
- W2113453462 cites W2024431372 @default.
- W2113453462 cites W2028726487 @default.
- W2113453462 cites W2032977708 @default.
- W2113453462 cites W2041156660 @default.
- W2113453462 cites W2050374206 @default.
- W2113453462 cites W2051683814 @default.
- W2113453462 cites W2054468210 @default.
- W2113453462 cites W2063013559 @default.
- W2113453462 cites W2063275754 @default.
- W2113453462 cites W2066618807 @default.
- W2113453462 cites W2067466498 @default.
- W2113453462 cites W2071638708 @default.
- W2113453462 cites W2088908073 @default.
- W2113453462 cites W2093048712 @default.
- W2113453462 cites W2097482835 @default.
- W2113453462 cites W2098337864 @default.
- W2113453462 cites W2105908798 @default.
- W2113453462 cites W2107134636 @default.
- W2113453462 cites W2109948920 @default.
- W2113453462 cites W2110625254 @default.
- W2113453462 cites W2112739348 @default.
- W2113453462 cites W2117528871 @default.
- W2113453462 cites W2121371748 @default.
- W2113453462 cites W2122573477 @default.
- W2113453462 cites W2124561611 @default.
- W2113453462 cites W2124599642 @default.
- W2113453462 cites W2127392515 @default.
- W2113453462 cites W2131978108 @default.
- W2113453462 cites W2139330894 @default.
- W2113453462 cites W2140040046 @default.
- W2113453462 cites W2147286372 @default.
- W2113453462 cites W2147533141 @default.
- W2113453462 cites W2152512072 @default.
- W2113453462 cites W2152600551 @default.
- W2113453462 cites W2158305336 @default.
- W2113453462 cites W2170780149 @default.
- W2113453462 doi "https://doi.org/10.1016/j.molcel.2013.08.019" @default.
- W2113453462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24035500" @default.
- W2113453462 hasPublicationYear "2013" @default.
- W2113453462 type Work @default.
- W2113453462 sameAs 2113453462 @default.
- W2113453462 citedByCount "71" @default.
- W2113453462 countsByYear W21134534622014 @default.
- W2113453462 countsByYear W21134534622015 @default.
- W2113453462 countsByYear W21134534622016 @default.
- W2113453462 countsByYear W21134534622017 @default.
- W2113453462 countsByYear W21134534622018 @default.
- W2113453462 countsByYear W21134534622019 @default.
- W2113453462 countsByYear W21134534622020 @default.
- W2113453462 countsByYear W21134534622021 @default.
- W2113453462 countsByYear W21134534622022 @default.
- W2113453462 countsByYear W21134534622023 @default.
- W2113453462 crossrefType "journal-article" @default.
- W2113453462 hasAuthorship W2113453462A5003312879 @default.
- W2113453462 hasAuthorship W2113453462A5007305472 @default.
- W2113453462 hasAuthorship W2113453462A5035434845 @default.
- W2113453462 hasAuthorship W2113453462A5037403931 @default.
- W2113453462 hasAuthorship W2113453462A5046222147 @default.
- W2113453462 hasAuthorship W2113453462A5051499117 @default.
- W2113453462 hasAuthorship W2113453462A5053457830 @default.
- W2113453462 hasAuthorship W2113453462A5077900527 @default.
- W2113453462 hasAuthorship W2113453462A5082924650 @default.
- W2113453462 hasAuthorship W2113453462A5089399852 @default.
- W2113453462 hasBestOaLocation W21134534621 @default.
- W2113453462 hasConcept C104317684 @default.
- W2113453462 hasConcept C12387725 @default.