FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113453712> ?p ?o ?g. }

• W2113453712 endingPage "1445" @default.
• W2113453712 startingPage "1438" @default.
• W2113453712 abstract "The lymphatic system plays a critical role in the maintenance of healthy tissues. Its function is an important indicator of the presence and extent of disease. In oncology, metastatic spread to local lymph nodes (LNs) is a strong predictor of poor outcome. Clinical methods for the visualization of LNs involve regional injection and tracking of ^99mTc-sulfur colloid (^99mTc-SC) along with absorbent dyes. Intraoperatively, these techniques suffer from the requirement of administration of multiple contrast media (^99mTc-SC and isosulfan blue), unwieldy γ-probes, and a short effective surgical window for dyes. Preclinically, imaging of transport through the lymphatics is further hindered by the resolution of lymphoscintigraphy and SPECT. We investigated multimodal imaging in animal models using intradermal administration of ¹⁸F-FDG for combined diagnostic and intraoperative use. PET visualizes LNs with high sensitivity and resolution and low background. Cerenkov radiation (CR) from ¹⁸F-FDG was evaluated to optically guide surgical resection of LNs. <b>Methods:</b> Imaging of ¹⁸F-FDG uptake used PET and sensitive luminescent imaging equipment (for CR). Dynamic PET was performed in both sexes and multiple strains (NCr Nude, C57BL/6, and Nu/Nu) of mice. Biodistribution confirmed the uptake of ¹⁸F-FDG and was compared with that of ^99mTc-SC. Verification of uptake and the ability to use ¹⁸F-FDG CR to guide nodal removal were confirmed histologically. <b>Results:</b> Intradermal injection of ¹⁸F-FDG clearly revealed lymphatic vessels and LNs by PET. Dynamic imaging revealed rapid and sustained labeling of these structures. Biodistribution of the radiotracer confirmed the active transport of radioglucose in the lymphatics to the local LNs and over time into the general circulation. ¹⁸F-FDG also enabled visualization of LNs through CR, even before surgically revealing the site, and guided LN resection. <b>Conclusion:</b> Intradermal ¹⁸F-FDG can enhance the preclinical investigation of the lymphatics through dynamic, high-resolution, and quantitative tomographic imaging. Clinically, combined PET/Cerenkov imaging has significant potential as a single-dose, dual-modality tracer for diagnostics (PET/CT) and guided resection of LNs (Cerenkov optical)." @default.
• W2113453712 created "2016-06-24" @default.
• W2113453712 creator A5016770897 @default.
• W2113453712 creator A5035464945 @default.
• W2113453712 creator A5056859109 @default.
• W2113453712 creator A5057343735 @default.
• W2113453712 creator A5058744719 @default.
• W2113453712 creator A5067808348 @default.
• W2113453712 creator A5069617434 @default.
• W2113453712 date "2012-08-07" @default.
• W2113453712 modified "2023-10-14" @default.
• W2113453712 title "Positron Lymphography: Multimodal, High-Resolution, Dynamic Mapping and Resection of Lymph Nodes After Intradermal Injection of ¹⁸F-FDG" @default.
• W2113453712 cites W173734626 @default.
• W2113453712 cites W1964094959 @default.
• W2113453712 cites W1966035094 @default.
• W2113453712 cites W1982773690 @default.
• W2113453712 cites W1992101966 @default.
• W2113453712 cites W1996715706 @default.
• W2113453712 cites W2006752077 @default.
• W2113453712 cites W2013896394 @default.
• W2113453712 cites W2020321814 @default.
• W2113453712 cites W2038307590 @default.
• W2113453712 cites W2045810642 @default.
• W2113453712 cites W2069799085 @default.
• W2113453712 cites W2073241541 @default.
• W2113453712 cites W2084090004 @default.
• W2113453712 cites W2086973839 @default.
• W2113453712 cites W2091461735 @default.
• W2113453712 cites W2092420790 @default.
• W2113453712 cites W2099010480 @default.
• W2113453712 cites W2099199155 @default.
• W2113453712 cites W2110655653 @default.
• W2113453712 cites W2115374812 @default.
• W2113453712 cites W2116810900 @default.
• W2113453712 cites W2120970035 @default.
• W2113453712 cites W2125328855 @default.
• W2113453712 cites W2128349096 @default.
• W2113453712 cites W2131365547 @default.
• W2113453712 cites W2135712089 @default.
• W2113453712 cites W2145558780 @default.
• W2113453712 cites W2148682579 @default.
• W2113453712 cites W2164508251 @default.
• W2113453712 cites W2189549602 @default.
• W2113453712 cites W2256865292 @default.
• W2113453712 cites W2317017044 @default.
• W2113453712 cites W4255451295 @default.
• W2113453712 cites W3021099835 @default.
• W2113453712 doi "https://doi.org/10.2967/jnumed.112.104349" @default.
• W2113453712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3537831" @default.
• W2113453712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22872741" @default.
• W2113453712 hasPublicationYear "2012" @default.
• W2113453712 type Work @default.
• W2113453712 sameAs 2113453712 @default.
• W2113453712 citedByCount "53" @default.
• W2113453712 countsByYear W21134537122013 @default.
• W2113453712 countsByYear W21134537122014 @default.
• W2113453712 countsByYear W21134537122015 @default.
• W2113453712 countsByYear W21134537122016 @default.
• W2113453712 countsByYear W21134537122017 @default.
• W2113453712 countsByYear W21134537122019 @default.
• W2113453712 countsByYear W21134537122020 @default.
• W2113453712 countsByYear W21134537122021 @default.
• W2113453712 countsByYear W21134537122022 @default.
• W2113453712 countsByYear W21134537122023 @default.
• W2113453712 crossrefType "journal-article" @default.
• W2113453712 hasAuthorship W2113453712A5016770897 @default.
• W2113453712 hasAuthorship W2113453712A5035464945 @default.
• W2113453712 hasAuthorship W2113453712A5056859109 @default.
• W2113453712 hasAuthorship W2113453712A5057343735 @default.
• W2113453712 hasAuthorship W2113453712A5058744719 @default.
• W2113453712 hasAuthorship W2113453712A5067808348 @default.
• W2113453712 hasAuthorship W2113453712A5069617434 @default.
• W2113453712 hasBestOaLocation W21134537121 @default.
• W2113453712 hasConcept C126838900 @default.
• W2113453712 hasConcept C136339569 @default.
• W2113453712 hasConcept C142724271 @default.
• W2113453712 hasConcept C150903083 @default.
• W2113453712 hasConcept C181152851 @default.
• W2113453712 hasConcept C185592680 @default.
• W2113453712 hasConcept C202751555 @default.
• W2113453712 hasConcept C207001950 @default.
• W2113453712 hasConcept C2775842073 @default.
• W2113453712 hasConcept C2777807558 @default.
• W2113453712 hasConcept C2779720271 @default.
• W2113453712 hasConcept C2984398910 @default.
• W2113453712 hasConcept C2989005 @default.
• W2113453712 hasConcept C31601959 @default.
• W2113453712 hasConcept C509974204 @default.
• W2113453712 hasConcept C55493867 @default.
• W2113453712 hasConcept C71924100 @default.
• W2113453712 hasConcept C86803240 @default.
• W2113453712 hasConceptScore W2113453712C126838900 @default.
• W2113453712 hasConceptScore W2113453712C136339569 @default.
• W2113453712 hasConceptScore W2113453712C142724271 @default.
• W2113453712 hasConceptScore W2113453712C150903083 @default.
• W2113453712 hasConceptScore W2113453712C181152851 @default.
• W2113453712 hasConceptScore W2113453712C185592680 @default.
• W2113453712 hasConceptScore W2113453712C202751555 @default.

• next