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• W2113455273 abstract "NMDA receptor-dependent synaptic modifications, such as long-term potentiation (LTP) and long-term depression (LTD), are essential for brain development and function. LTD occurs mainly by the removal of AMPA receptors from the postsynaptic membrane, but the underlying molecular mechanisms remain unclear. Here, we show that activation of caspase-3 via mitochondria is required for LTD and AMPA receptor internalization in hippocampal neurons. LTD and AMPA receptor internalization are blocked by peptide inhibitors of caspase-3 and -9. In hippocampal slices from caspase-3 knockout mice, LTD is abolished whereas LTP remains normal. LTD is also prevented by overexpression of the anti-apoptotic proteins XIAP or Bcl-xL, and by a mutant Akt1 protein that is resistant to caspase-3 proteolysis. NMDA receptor stimulation that induces LTD transiently activates caspase-3 in dendrites, without causing cell death. These data indicate an unexpected causal link between the molecular mechanisms of apoptosis and LTD." @default.
• W2113455273 created "2016-06-24" @default.
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• W2113455273 date "2010-05-01" @default.
• W2113455273 modified "2023-10-09" @default.
• W2113455273 title "Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization" @default.
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• W2113455273 doi "https://doi.org/10.1016/j.cell.2010.03.053" @default.
• W2113455273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2909748" @default.
• W2113455273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20510932" @default.
• W2113455273 hasPublicationYear "2010" @default.
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