Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113456839> ?p ?o ?g. }
- W2113456839 endingPage "285" @default.
- W2113456839 startingPage "274" @default.
- W2113456839 abstract "Objective: There is a growing need to identify cerebrospinal fluid (CSF) markers that can detect Alzheimer's disease (AD) pathology in cognitively normal individuals because it is in this population that disease-modifying therapies may have the greatest chance of success. While AD pathology is estimated to begin ∼10–15 years prior to the onset of cognitive decline, substantial neuronal loss is present by the time the earliest signs of cognitive impairment appear. Visinin-like protein-1 (VILIP-1) has demonstrated potential utility as a marker of neuronal injury. Here we investigate CSF VILIP-1 and VILIP-1/amyloid-β42 (Aβ42) ratio as diagnostic and prognostic markers in early AD. Methods: We assessed CSF levels of VILIP-1, tau, phosphorylated-tau181 (p-tau181), and Aβ42 in cognitively normal controls (CNC) (n = 211), individuals with early symptomatic AD (n = 98), and individuals with other dementias (n = 19). Structural magnetic resonance imaging (n = 192) and amyloid imaging with Pittsburgh Compound-B (n = 156) were obtained in subsets of this cohort. Among the CNC cohort, 164 individuals had follow-up annual cognitive assessments for 2–3 years. Results: CSF VILIP-1 levels differentiated individuals with AD from CNC and individuals with other dementias. CSF VILIP-1 levels correlated with CSF tau, p-tau181, and brain volumes in AD. VILIP-1 and VILIP-1/Aβ42 predicted future cognitive impairment in CNC over the follow-up period. Importantly, CSF VILIP-1/Aβ42 predicted future cognitive impairment at least as well as tau/Aβ42 and p-tau181/Aβ42. Interpretation: These findings suggest that CSF VILIP-1 and VILIP-1/Aβ42 offer diagnostic utility for early AD, and can predict future cognitive impairment in cognitively normal individuals similarly to tau and tau/Aβ42, respectively. ANN NEUROL 2011" @default.
- W2113456839 created "2016-06-24" @default.
- W2113456839 creator A5016464491 @default.
- W2113456839 creator A5017557589 @default.
- W2113456839 creator A5025837253 @default.
- W2113456839 creator A5026479455 @default.
- W2113456839 creator A5039474672 @default.
- W2113456839 creator A5054917382 @default.
- W2113456839 creator A5058689740 @default.
- W2113456839 creator A5063630764 @default.
- W2113456839 creator A5072010327 @default.
- W2113456839 creator A5073976995 @default.
- W2113456839 creator A5077392976 @default.
- W2113456839 creator A5082220804 @default.
- W2113456839 creator A5088998527 @default.
- W2113456839 date "2011-08-01" @default.
- W2113456839 modified "2023-10-18" @default.
- W2113456839 title "Visinin-like protein-1: Diagnostic and prognostic biomarker in Alzheimer disease" @default.
- W2113456839 cites W156047692 @default.
- W2113456839 cites W1847168837 @default.
- W2113456839 cites W1847812830 @default.
- W2113456839 cites W1965616054 @default.
- W2113456839 cites W1967642097 @default.
- W2113456839 cites W1972340735 @default.
- W2113456839 cites W1974583546 @default.
- W2113456839 cites W1980842500 @default.
- W2113456839 cites W1984009511 @default.
- W2113456839 cites W1988370080 @default.
- W2113456839 cites W1991952617 @default.
- W2113456839 cites W2000407712 @default.
- W2113456839 cites W2000566928 @default.
- W2113456839 cites W2005072207 @default.
- W2113456839 cites W2006858320 @default.
- W2113456839 cites W2007350172 @default.
- W2113456839 cites W2016632685 @default.
- W2113456839 cites W2031293980 @default.
- W2113456839 cites W2032276337 @default.
- W2113456839 cites W2036014270 @default.
- W2113456839 cites W2040434160 @default.
- W2113456839 cites W2043827506 @default.
- W2113456839 cites W2052132290 @default.
- W2113456839 cites W2052742260 @default.
- W2113456839 cites W2065272728 @default.
- W2113456839 cites W2065423268 @default.
- W2113456839 cites W2080274663 @default.
- W2113456839 cites W2085558649 @default.
- W2113456839 cites W2088129757 @default.
- W2113456839 cites W2089804237 @default.
- W2113456839 cites W2092517981 @default.
- W2113456839 cites W2094375064 @default.
- W2113456839 cites W2101188587 @default.
- W2113456839 cites W2112628686 @default.
- W2113456839 cites W2125874903 @default.
- W2113456839 cites W2131830246 @default.
- W2113456839 cites W2136557657 @default.
- W2113456839 cites W2141854336 @default.
- W2113456839 cites W2158165932 @default.
- W2113456839 cites W2161737267 @default.
- W2113456839 cites W2166207589 @default.
- W2113456839 cites W2167840686 @default.
- W2113456839 doi "https://doi.org/10.1002/ana.22448" @default.
- W2113456839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3154071" @default.
- W2113456839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21823155" @default.
- W2113456839 hasPublicationYear "2011" @default.
- W2113456839 type Work @default.
- W2113456839 sameAs 2113456839 @default.
- W2113456839 citedByCount "134" @default.
- W2113456839 countsByYear W21134568392012 @default.
- W2113456839 countsByYear W21134568392013 @default.
- W2113456839 countsByYear W21134568392014 @default.
- W2113456839 countsByYear W21134568392015 @default.
- W2113456839 countsByYear W21134568392016 @default.
- W2113456839 countsByYear W21134568392017 @default.
- W2113456839 countsByYear W21134568392018 @default.
- W2113456839 countsByYear W21134568392019 @default.
- W2113456839 countsByYear W21134568392020 @default.
- W2113456839 countsByYear W21134568392021 @default.
- W2113456839 countsByYear W21134568392022 @default.
- W2113456839 countsByYear W21134568392023 @default.
- W2113456839 crossrefType "journal-article" @default.
- W2113456839 hasAuthorship W2113456839A5016464491 @default.
- W2113456839 hasAuthorship W2113456839A5017557589 @default.
- W2113456839 hasAuthorship W2113456839A5025837253 @default.
- W2113456839 hasAuthorship W2113456839A5026479455 @default.
- W2113456839 hasAuthorship W2113456839A5039474672 @default.
- W2113456839 hasAuthorship W2113456839A5054917382 @default.
- W2113456839 hasAuthorship W2113456839A5058689740 @default.
- W2113456839 hasAuthorship W2113456839A5063630764 @default.
- W2113456839 hasAuthorship W2113456839A5072010327 @default.
- W2113456839 hasAuthorship W2113456839A5073976995 @default.
- W2113456839 hasAuthorship W2113456839A5077392976 @default.
- W2113456839 hasAuthorship W2113456839A5082220804 @default.
- W2113456839 hasAuthorship W2113456839A5088998527 @default.
- W2113456839 hasBestOaLocation W21134568392 @default.
- W2113456839 hasConcept C118552586 @default.
- W2113456839 hasConcept C126322002 @default.
- W2113456839 hasConcept C126838900 @default.
- W2113456839 hasConcept C142724271 @default.