Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113457114> ?p ?o ?g. }
- W2113457114 endingPage "R1489" @default.
- W2113457114 startingPage "R1479" @default.
- W2113457114 abstract "Heat dissipation from the rat's tail is reduced in response to cold and during fever. The sympathetic premotor neurons for this mechanism, located in the medullary raphé, are under tonic inhibitory control from the preoptic area. In parallel with the inhibitory pathway, an excitatory pathway from the rostromedial preoptic region (RMPO) to the medullary raphé mediates the vasoconstrictor response to cold skin. Whether this applies also to the tail vasoconstrictor response in fever is unknown. Single- or a few-unit tail sympathetic nerve activity (SNA) was recorded in urethane-anesthetized, artificially ventilated rats. Experimental fever was induced by PGE 2 injected into the lateral cerebral ventricle (50 ng in 1.5 μl icv) or into the RMPO (0.2 ng in 60 nl); in both cases, there was a robust increase in tail SNA and a delayed rise in core temperature. Microinjection of glutamate receptor antagonist kynurenate (50 mM, 120 nl) into the medullary raphé completely reversed the tail SNA response to intracerebroventricular or RMPO PGE 2 injection. Inhibiting RMPO neurons by microinjecting glycine (0.5 M, 60 nl) or the GABA A receptor agonist, muscimol (2 mM, 30–60 nl), reduced the tail SNA response to PGE 2 injected into the same site by approximately half. Vehicle injections into the medullary raphé or RMPO were without effect. These results suggest that the tail vasoconstrictor response during experimental fever depends on a glutamatergic excitatory synaptic relay in the medullary raphé and that an excitatory output signal from the RMPO contributes to the tail vasoconstrictor response during fever." @default.
- W2113457114 created "2016-06-24" @default.
- W2113457114 creator A5040291031 @default.
- W2113457114 creator A5043075846 @default.
- W2113457114 creator A5062764483 @default.
- W2113457114 date "2013-12-15" @default.
- W2113457114 modified "2023-10-12" @default.
- W2113457114 title "Role of an excitatory preoptic-raphé pathway in febrile vasoconstriction of the rat's tail" @default.
- W2113457114 cites W103292242 @default.
- W2113457114 cites W1495726008 @default.
- W2113457114 cites W1573141201 @default.
- W2113457114 cites W1604815012 @default.
- W2113457114 cites W1647648618 @default.
- W2113457114 cites W1845449766 @default.
- W2113457114 cites W1949243835 @default.
- W2113457114 cites W1972615540 @default.
- W2113457114 cites W1972876876 @default.
- W2113457114 cites W1973421554 @default.
- W2113457114 cites W1978596106 @default.
- W2113457114 cites W1989322189 @default.
- W2113457114 cites W1993098410 @default.
- W2113457114 cites W1995301708 @default.
- W2113457114 cites W1998963802 @default.
- W2113457114 cites W2002338746 @default.
- W2113457114 cites W2003343375 @default.
- W2113457114 cites W2006678562 @default.
- W2113457114 cites W2008262700 @default.
- W2113457114 cites W2013434683 @default.
- W2113457114 cites W2014738430 @default.
- W2113457114 cites W2016968392 @default.
- W2113457114 cites W2017818654 @default.
- W2113457114 cites W2021659985 @default.
- W2113457114 cites W2022350658 @default.
- W2113457114 cites W2031280687 @default.
- W2113457114 cites W2033887998 @default.
- W2113457114 cites W2035193234 @default.
- W2113457114 cites W2036438525 @default.
- W2113457114 cites W2039016375 @default.
- W2113457114 cites W2043296272 @default.
- W2113457114 cites W2045698750 @default.
- W2113457114 cites W2049400155 @default.
- W2113457114 cites W2049673881 @default.
- W2113457114 cites W2057478756 @default.
- W2113457114 cites W2062928716 @default.
- W2113457114 cites W2067542258 @default.
- W2113457114 cites W2069702071 @default.
- W2113457114 cites W2076560972 @default.
- W2113457114 cites W2091883907 @default.
- W2113457114 cites W2094070085 @default.
- W2113457114 cites W2095950170 @default.
- W2113457114 cites W2111072003 @default.
- W2113457114 cites W2115044649 @default.
- W2113457114 cites W2117551879 @default.
- W2113457114 cites W2121612337 @default.
- W2113457114 cites W2125596453 @default.
- W2113457114 cites W2134405522 @default.
- W2113457114 cites W2137234744 @default.
- W2113457114 cites W2140161618 @default.
- W2113457114 cites W2147128496 @default.
- W2113457114 cites W2164705373 @default.
- W2113457114 cites W2171855585 @default.
- W2113457114 cites W2184323212 @default.
- W2113457114 doi "https://doi.org/10.1152/ajpregu.00401.2013" @default.
- W2113457114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24133101" @default.
- W2113457114 hasPublicationYear "2013" @default.
- W2113457114 type Work @default.
- W2113457114 sameAs 2113457114 @default.
- W2113457114 citedByCount "17" @default.
- W2113457114 countsByYear W21134571142014 @default.
- W2113457114 countsByYear W21134571142015 @default.
- W2113457114 countsByYear W21134571142016 @default.
- W2113457114 countsByYear W21134571142017 @default.
- W2113457114 countsByYear W21134571142018 @default.
- W2113457114 countsByYear W21134571142019 @default.
- W2113457114 countsByYear W21134571142020 @default.
- W2113457114 countsByYear W21134571142021 @default.
- W2113457114 countsByYear W21134571142022 @default.
- W2113457114 crossrefType "journal-article" @default.
- W2113457114 hasAuthorship W2113457114A5040291031 @default.
- W2113457114 hasAuthorship W2113457114A5043075846 @default.
- W2113457114 hasAuthorship W2113457114A5062764483 @default.
- W2113457114 hasConcept C112592302 @default.
- W2113457114 hasConcept C126322002 @default.
- W2113457114 hasConcept C134018914 @default.
- W2113457114 hasConcept C170493617 @default.
- W2113457114 hasConcept C17077164 @default.
- W2113457114 hasConcept C185592680 @default.
- W2113457114 hasConcept C2775864247 @default.
- W2113457114 hasConcept C2777615928 @default.
- W2113457114 hasConcept C37000724 @default.
- W2113457114 hasConcept C71924100 @default.
- W2113457114 hasConcept C86803240 @default.
- W2113457114 hasConceptScore W2113457114C112592302 @default.
- W2113457114 hasConceptScore W2113457114C126322002 @default.
- W2113457114 hasConceptScore W2113457114C134018914 @default.
- W2113457114 hasConceptScore W2113457114C170493617 @default.
- W2113457114 hasConceptScore W2113457114C17077164 @default.
- W2113457114 hasConceptScore W2113457114C185592680 @default.