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- W2113458499 endingPage "492" @default.
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- W2113458499 abstract "Objectives. Previous studies have suggested that the pathogenesis of schizophrenia and major depression involves an altered peripheral immune system. It is not clear, however, whether such changes are associated with corresponding neuroinflammatory responses and disturbances of neurotransmission. Methods. This paper reviews the current state of knowledge about the involvement of immune alterations in schizophrenia and major depression and a possible link to disturbances of glutamatergic transmission. Results. Inflammatory endogenous modulators of the NMDA receptor, the kynurenine pathway metabolites, are potential candidates for such a link. Studies of the blood and cerebrospinal fluid have suggested a schizophrenia-related upregulation of the NMDA receptor antagonist kynurenic acid in astrocytes, analogous to the ketamine psychosis model. Conversely, it has been proposed that there is depression-related microglial synthesis of the NMDA receptor agonist quinolinic acid, which is consistent with the observation that ketamine has therapeutic effects in major depression. Few publications have studied NMDA receptor modulating kynurenines in the brain, however. Conclusions. Future research on the cerebral cell-type specific distribution of kynurenine metabolites and their brain-regional concentration imbalances will be required to connect peripheral immune changes, the hypotheses of blood–brain barrier dysfunction and glial pathology with concepts of altered neurotransmission in schizophrenia and major depression." @default.
- W2113458499 created "2016-06-24" @default.
- W2113458499 creator A5002985304 @default.
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- W2113458499 creator A5028194059 @default.
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- W2113458499 creator A5071035870 @default.
- W2113458499 creator A5072756628 @default.
- W2113458499 creator A5080169126 @default.
- W2113458499 date "2011-06-28" @default.
- W2113458499 modified "2023-10-14" @default.
- W2113458499 title "Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood–brain barrier integrity" @default.
- W2113458499 cites W1225620574 @default.
- W2113458499 cites W144856505 @default.
- W2113458499 cites W1547937746 @default.
- W2113458499 cites W1559088113 @default.
- W2113458499 cites W1571021606 @default.
- W2113458499 cites W1581767355 @default.
- W2113458499 cites W1597677460 @default.
- W2113458499 cites W1936730453 @default.
- W2113458499 cites W1964709968 @default.
- W2113458499 cites W1965020733 @default.
- W2113458499 cites W1967545898 @default.
- W2113458499 cites W1968248096 @default.
- W2113458499 cites W1968374987 @default.
- W2113458499 cites W1969205004 @default.
- W2113458499 cites W1973172818 @default.
- W2113458499 cites W1976242105 @default.
- W2113458499 cites W1978238793 @default.
- W2113458499 cites W1979926045 @default.
- W2113458499 cites W1981026552 @default.
- W2113458499 cites W1981548074 @default.
- W2113458499 cites W1984897546 @default.
- W2113458499 cites W1985615482 @default.
- W2113458499 cites W1985836432 @default.
- W2113458499 cites W1988105902 @default.
- W2113458499 cites W1989199068 @default.
- W2113458499 cites W1989598267 @default.
- W2113458499 cites W1989634440 @default.
- W2113458499 cites W1989781329 @default.
- W2113458499 cites W1991526830 @default.
- W2113458499 cites W1993254538 @default.
- W2113458499 cites W1995245208 @default.
- W2113458499 cites W1996454121 @default.
- W2113458499 cites W2000235837 @default.
- W2113458499 cites W2003712515 @default.
- W2113458499 cites W2003869950 @default.
- W2113458499 cites W2004340733 @default.
- W2113458499 cites W2006031776 @default.
- W2113458499 cites W2009672399 @default.
- W2113458499 cites W2009772283 @default.
- W2113458499 cites W2012520574 @default.
- W2113458499 cites W2013524799 @default.
- W2113458499 cites W2016713681 @default.
- W2113458499 cites W2017661386 @default.
- W2113458499 cites W2018249782 @default.
- W2113458499 cites W2020444377 @default.
- W2113458499 cites W2024251150 @default.
- W2113458499 cites W2024575964 @default.
- W2113458499 cites W2027762021 @default.
- W2113458499 cites W2027876558 @default.
- W2113458499 cites W2028370746 @default.
- W2113458499 cites W2030284017 @default.
- W2113458499 cites W2030396834 @default.
- W2113458499 cites W2034387476 @default.
- W2113458499 cites W2036194983 @default.
- W2113458499 cites W2037084854 @default.
- W2113458499 cites W2038871880 @default.
- W2113458499 cites W2042513568 @default.
- W2113458499 cites W2042731928 @default.
- W2113458499 cites W2042847268 @default.
- W2113458499 cites W2043077656 @default.
- W2113458499 cites W2046572145 @default.
- W2113458499 cites W2047704511 @default.
- W2113458499 cites W2050792638 @default.
- W2113458499 cites W2051353156 @default.
- W2113458499 cites W2052576278 @default.
- W2113458499 cites W2052960151 @default.
- W2113458499 cites W2053327244 @default.
- W2113458499 cites W2053818485 @default.
- W2113458499 cites W2054492621 @default.
- W2113458499 cites W2059312295 @default.
- W2113458499 cites W2063235053 @default.
- W2113458499 cites W2068751924 @default.
- W2113458499 cites W2069462624 @default.
- W2113458499 cites W2069465895 @default.
- W2113458499 cites W2069782517 @default.
- W2113458499 cites W2071093227 @default.
- W2113458499 cites W2072328883 @default.
- W2113458499 cites W2074596375 @default.
- W2113458499 cites W2083873586 @default.
- W2113458499 cites W2084120702 @default.
- W2113458499 cites W2084588595 @default.
- W2113458499 cites W2085301448 @default.
- W2113458499 cites W2088132943 @default.
- W2113458499 cites W2088275582 @default.
- W2113458499 cites W2088703717 @default.
- W2113458499 cites W2095340735 @default.