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• W2113458825 abstract "Background and purpose To determine whether radical prostatectomy (RP) or intensity-modulated radiation therapy (IMRT) to ⩾72 Gy, plus hormonal therapy if indicated, results in improved biochemical disease-free survival (BDFS) in localized prostate adenocarcinoma. Materials and methods Between 1997 and 2005, a consecutive sample of 556 patients who underwent RP (n = 204) or IMRT (n = 352) at two referral centers was analyzed. The patients were stratified into prognostic groups based on clinical stage, Gleason score, and pretreatment prostate-specific antigen (PSA). The outcome measure was BDFS. Results IMRT patients had more advanced disease at baseline (p < .001). There was no difference in five-year BDFS rates between RP and IMRT in the favorable (92.8% vs. 85.3%, p = .20) or intermediate prognosis (86.7% vs. 82.2%, p = .46) subsets. A difference favoring IMRT plus hormonal therapy was seen in the poor prognosis (38.4% vs. 62.2%, p < .001) subset. Within the entire cohort, after adjustment for confounding variables, Gleason score (p < .001) and clinical stage (p < .001) predicted BDFS, but treatment modality (p = .06) did not. Within the poor prognosis subset, treatment modality (p = .006) predicted BDFS. Conclusions BDFS is similar between RP and IMRT for patients with a favorable or intermediate prognosis. Patients with a poor prognosis display higher BDFS when treated with IMRT to ⩾72 Gy plus hormonal therapy." @default.
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• W2113458825 date "2009-11-01" @default.
• W2113458825 modified "2023-09-24" @default.
• W2113458825 title "Radical prostatectomy vs. intensity-modulated radiation therapy in the management of localized prostate adenocarcinoma" @default.
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• W2113458825 doi "https://doi.org/10.1016/j.radonc.2009.09.001" @default.
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