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- W2113459738 abstract "The aim of this work is to develop and validate a dissolution test for glibenclamide tablets. Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and using equipment with six vessels. The derivative UV spectrophotometric method for determination of glibenclamide released was developed, validated and compared with the HPLC method. The UVDS method presents linearity (r² = 0.9999) in the concentration range of 5-14 µg/mL. Precision and recoveries were 0.42% and 100.25%, respectively. The method was applied to three products commercially available on the Brazilian market." @default.
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- W2113459738 date "2007-10-01" @default.
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- W2113459738 title "Dissolution test for glibenclamide tablets" @default.
- W2113459738 doi "https://doi.org/10.1590/s0100-40422007000500031" @default.
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