FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113470718> ?p ?o ?g. }

• W2113470718 endingPage "448" @default.
• W2113470718 startingPage "443" @default.
• W2113470718 abstract "Expression of urocortin (Ucn) in the human benign prostate and prostate cancer has been reported recently. Ucn binds and activates corticotropin releasing factor (CRF) receptor 1 (CRFR1) and 2 (CRFR2). Activation of CRFR2 has been shown to inhibit tumor growth by regulation of proliferation and apoptosis as well as suppression of vascularization. However, there is no report demonstrating expression profile of CRFR2 in normal prostate versus prostate cancer.CRFR2 mRNA expression was assessed in human normal prostate and prostate cancer by reverse transcriptase PCR. CRFR2 expression on protein level has been performed using double staining immunofluorescence (IF) of tissue microarrays of 32 cases of prostatic adenocarcioma with corresponding normal tissues. Confocal microscopy was carried out to visualize the immunostaining.PCR of normal prostate lysates exhibited specific signals for CRFR2 mRNA. However PCR of lysates of prostate cancer exhibited no signal for CRFR2 mRNA. IF study exhibited that smooth muscle components of the stroma and endothelial cells of blood vessels express an extensive staining for CRFR2. In a lesser extend vascular smooth muscle cells expressed CRFR2. The tumoral neovascular system and stroma exhibited no immunopositivity for CRFR2.The present study demonstrates for the first time that human benign prostate tissue and prostate cancer specimen differentially express CRFR2. While Ucn expression in prostate cancer has been shown to be identical to non-malignant prostate tissues, we hypothesize that expression loss of CRFR2 in prostate cancer and its neovascularization contributes to prostate tumorigenesis, progression, and neoangiogenesis." @default.
• W2113470718 created "2016-06-24" @default.
• W2113470718 creator A5003254533 @default.
• W2113470718 creator A5010930426 @default.
• W2113470718 creator A5016971686 @default.
• W2113470718 creator A5061420871 @default.
• W2113470718 creator A5064143841 @default.
• W2113470718 creator A5080116321 @default.
• W2113470718 date "2009-03-01" @default.
• W2113470718 modified "2023-10-17" @default.
• W2113470718 title "The involvement of altered corticotropin releasing factor receptor 2 expression in prostate cancer due to alteration of anti-angiogenic signaling pathways" @default.
• W2113470718 cites W1966035396 @default.
• W2113470718 cites W1969372723 @default.
• W2113470718 cites W1984696385 @default.
• W2113470718 cites W1989918919 @default.
• W2113470718 cites W1993539031 @default.
• W2113470718 cites W1999524354 @default.
• W2113470718 cites W2000320905 @default.
• W2113470718 cites W2003079927 @default.
• W2113470718 cites W2004533973 @default.
• W2113470718 cites W2006055974 @default.
• W2113470718 cites W2010506120 @default.
• W2113470718 cites W2016448006 @default.
• W2113470718 cites W2023967939 @default.
• W2113470718 cites W2041863971 @default.
• W2113470718 cites W2043103956 @default.
• W2113470718 cites W2053831799 @default.
• W2113470718 cites W2054550208 @default.
• W2113470718 cites W2074379258 @default.
• W2113470718 cites W2086232140 @default.
• W2113470718 cites W2088614549 @default.
• W2113470718 cites W2092247393 @default.
• W2113470718 cites W2094853228 @default.
• W2113470718 cites W2097643376 @default.
• W2113470718 cites W2098930711 @default.
• W2113470718 cites W2110838145 @default.
• W2113470718 cites W2112357539 @default.
• W2113470718 cites W2119571883 @default.
• W2113470718 cites W2153309812 @default.
• W2113470718 cites W63022044 @default.
• W2113470718 doi "https://doi.org/10.1002/pros.20892" @default.
• W2113470718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19058138" @default.
• W2113470718 hasPublicationYear "2009" @default.
• W2113470718 type Work @default.
• W2113470718 sameAs 2113470718 @default.
• W2113470718 citedByCount "25" @default.
• W2113470718 countsByYear W21134707182012 @default.
• W2113470718 countsByYear W21134707182013 @default.
• W2113470718 countsByYear W21134707182014 @default.
• W2113470718 countsByYear W21134707182015 @default.
• W2113470718 countsByYear W21134707182016 @default.
• W2113470718 countsByYear W21134707182018 @default.
• W2113470718 countsByYear W21134707182019 @default.
• W2113470718 countsByYear W21134707182022 @default.
• W2113470718 crossrefType "journal-article" @default.
• W2113470718 hasAuthorship W2113470718A5003254533 @default.
• W2113470718 hasAuthorship W2113470718A5010930426 @default.
• W2113470718 hasAuthorship W2113470718A5016971686 @default.
• W2113470718 hasAuthorship W2113470718A5061420871 @default.
• W2113470718 hasAuthorship W2113470718A5064143841 @default.
• W2113470718 hasAuthorship W2113470718A5080116321 @default.
• W2113470718 hasConcept C121608353 @default.
• W2113470718 hasConcept C126322002 @default.
• W2113470718 hasConcept C142724271 @default.
• W2113470718 hasConcept C204232928 @default.
• W2113470718 hasConcept C2776235491 @default.
• W2113470718 hasConcept C2780192828 @default.
• W2113470718 hasConcept C4224716 @default.
• W2113470718 hasConcept C502942594 @default.
• W2113470718 hasConcept C52124034 @default.
• W2113470718 hasConcept C555283112 @default.
• W2113470718 hasConcept C71924100 @default.
• W2113470718 hasConcept C86803240 @default.
• W2113470718 hasConcept C87874733 @default.
• W2113470718 hasConceptScore W2113470718C121608353 @default.
• W2113470718 hasConceptScore W2113470718C126322002 @default.
• W2113470718 hasConceptScore W2113470718C142724271 @default.
• W2113470718 hasConceptScore W2113470718C204232928 @default.
• W2113470718 hasConceptScore W2113470718C2776235491 @default.
• W2113470718 hasConceptScore W2113470718C2780192828 @default.
• W2113470718 hasConceptScore W2113470718C4224716 @default.
• W2113470718 hasConceptScore W2113470718C502942594 @default.
• W2113470718 hasConceptScore W2113470718C52124034 @default.
• W2113470718 hasConceptScore W2113470718C555283112 @default.
• W2113470718 hasConceptScore W2113470718C71924100 @default.
• W2113470718 hasConceptScore W2113470718C86803240 @default.
• W2113470718 hasConceptScore W2113470718C87874733 @default.
• W2113470718 hasIssue "4" @default.
• W2113470718 hasLocation W21134707181 @default.
• W2113470718 hasLocation W21134707182 @default.
• W2113470718 hasOpenAccess W2113470718 @default.
• W2113470718 hasPrimaryLocation W21134707181 @default.
• W2113470718 hasRelatedWork W2005358418 @default.
• W2113470718 hasRelatedWork W2016249226 @default.
• W2113470718 hasRelatedWork W2022498945 @default.
• W2113470718 hasRelatedWork W2059972578 @default.
• W2113470718 hasRelatedWork W2085110745 @default.
• W2113470718 hasRelatedWork W2113470718 @default.

• next