Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113471942> ?p ?o ?g. }
- W2113471942 endingPage "1012" @default.
- W2113471942 startingPage "1001" @default.
- W2113471942 abstract "Cells control their own death through a program termed apoptosis, which is indispensable for development and homeostasis in all metazoans. Lysosomal cysteine proteases are not normally thought of as participating in apoptosis; however, recent reports have shown that the cathepsin proteases can be released from the lysosome during apoptosis, where they can participate in cell death. We report here the development of an activity-based probe that, under optimized conditions, reports on cathepsin B activity only in apoptotic cells by reading out the release of cathepsin B from the lysosomes. Biochemical characterization of apoptosis in cells from cathepsin B null mice shows delayed and suboptimal activation of caspases. Our data further supports a role for cathepsin B in the cytosol as a positive regulator of a cell death feed-forward loop and provides a chemical tool for future investigations." @default.
- W2113471942 created "2016-06-24" @default.
- W2113471942 creator A5007177053 @default.
- W2113471942 creator A5029695984 @default.
- W2113471942 creator A5031060352 @default.
- W2113471942 creator A5085462355 @default.
- W2113471942 date "2009-09-01" @default.
- W2113471942 modified "2023-09-28" @default.
- W2113471942 title "Direct Measurement of Cathepsin B Activity in the Cytosol of Apoptotic Cells by an Activity-Based Probe" @default.
- W2113471942 cites W1540436551 @default.
- W2113471942 cites W1607080847 @default.
- W2113471942 cites W1607777232 @default.
- W2113471942 cites W1812339273 @default.
- W2113471942 cites W1825621539 @default.
- W2113471942 cites W1855617936 @default.
- W2113471942 cites W1890027265 @default.
- W2113471942 cites W1895906686 @default.
- W2113471942 cites W1944354882 @default.
- W2113471942 cites W1968766748 @default.
- W2113471942 cites W1971199972 @default.
- W2113471942 cites W1981659539 @default.
- W2113471942 cites W1989841673 @default.
- W2113471942 cites W1999487949 @default.
- W2113471942 cites W2006193439 @default.
- W2113471942 cites W2008693250 @default.
- W2113471942 cites W2009304941 @default.
- W2113471942 cites W2010243701 @default.
- W2113471942 cites W2011859788 @default.
- W2113471942 cites W2013583594 @default.
- W2113471942 cites W2018327323 @default.
- W2113471942 cites W2019631673 @default.
- W2113471942 cites W2021320094 @default.
- W2113471942 cites W2024105041 @default.
- W2113471942 cites W2025062557 @default.
- W2113471942 cites W2027386250 @default.
- W2113471942 cites W2031586032 @default.
- W2113471942 cites W2034269086 @default.
- W2113471942 cites W2050358188 @default.
- W2113471942 cites W2051433821 @default.
- W2113471942 cites W2051807429 @default.
- W2113471942 cites W2060430618 @default.
- W2113471942 cites W2060470491 @default.
- W2113471942 cites W2061642324 @default.
- W2113471942 cites W2062203284 @default.
- W2113471942 cites W2063159238 @default.
- W2113471942 cites W2064769518 @default.
- W2113471942 cites W2065518020 @default.
- W2113471942 cites W2076107014 @default.
- W2113471942 cites W2083106544 @default.
- W2113471942 cites W2088659758 @default.
- W2113471942 cites W2089627345 @default.
- W2113471942 cites W2090985686 @default.
- W2113471942 cites W2122826329 @default.
- W2113471942 cites W2127893782 @default.
- W2113471942 cites W2132508709 @default.
- W2113471942 cites W2134388096 @default.
- W2113471942 cites W2135233980 @default.
- W2113471942 cites W2142280970 @default.
- W2113471942 cites W2146267741 @default.
- W2113471942 cites W2147105537 @default.
- W2113471942 cites W2152826290 @default.
- W2113471942 cites W2157999078 @default.
- W2113471942 cites W2171744625 @default.
- W2113471942 cites W2750896950 @default.
- W2113471942 cites W52745064 @default.
- W2113471942 doi "https://doi.org/10.1016/j.chembiol.2009.07.011" @default.
- W2113471942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3115634" @default.
- W2113471942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19778728" @default.
- W2113471942 hasPublicationYear "2009" @default.
- W2113471942 type Work @default.
- W2113471942 sameAs 2113471942 @default.
- W2113471942 citedByCount "36" @default.
- W2113471942 countsByYear W21134719422012 @default.
- W2113471942 countsByYear W21134719422013 @default.
- W2113471942 countsByYear W21134719422014 @default.
- W2113471942 countsByYear W21134719422015 @default.
- W2113471942 countsByYear W21134719422016 @default.
- W2113471942 countsByYear W21134719422017 @default.
- W2113471942 countsByYear W21134719422018 @default.
- W2113471942 countsByYear W21134719422019 @default.
- W2113471942 countsByYear W21134719422020 @default.
- W2113471942 countsByYear W21134719422021 @default.
- W2113471942 countsByYear W21134719422022 @default.
- W2113471942 crossrefType "journal-article" @default.
- W2113471942 hasAuthorship W2113471942A5007177053 @default.
- W2113471942 hasAuthorship W2113471942A5029695984 @default.
- W2113471942 hasAuthorship W2113471942A5031060352 @default.
- W2113471942 hasAuthorship W2113471942A5085462355 @default.
- W2113471942 hasBestOaLocation W21134719421 @default.
- W2113471942 hasConcept C151701858 @default.
- W2113471942 hasConcept C167844969 @default.
- W2113471942 hasConcept C173633252 @default.
- W2113471942 hasConcept C181199279 @default.
- W2113471942 hasConcept C182220744 @default.
- W2113471942 hasConcept C190283241 @default.
- W2113471942 hasConcept C2780034444 @default.
- W2113471942 hasConcept C2780216420 @default.
- W2113471942 hasConcept C28021979 @default.