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• W2113472764 abstract "Background and purpose Initial results of Stereotactic Ablative Body Radiotherapy (SABR) in the treatment of localized prostate cancer appear promising however long-term quality of life (QOL) outcomes and dosimetric correlates are necessary. Material and methods A phase I/II study was performed where low risk prostate cancer patients received SABR 35 Gy in 5 fractions, once weekly. Patient self-reported QOL was measured using the Expanded Prostate Cancer Index Composite (EPIC) at baseline and q6 month up to 5 years. Urinary, bowel and sexual domains were analyzed. A minimally clinical important change (MCIC) was defined as 0.5 ∗ standard deviation of the baseline. Univariate and multivariate logistic regression were used to identify dosimetric predictors of MCIC. Results 84 patients were included. The median follow-up was 50.8 months (interquartile range [IQR], 44.7–56.3). 17.9%, 26.2% and 37.5% of patients reported worse QOL on follow up in the urinary, bowel and sexual domains respectively. On univariate analysis Rectal V31.8 > 10%, D1cc > 35 Gy were associated with bowel MCIC, penile bulb (PB) V35 > 4%, V20 > 40% with sexual MCIC. Of these factors only rectal D1cc and PB V35 were predictors of worse QOL on multivariate analysis. Conclusions Long-term single-institution QOL outcomes are encouraging. Rigorous dosimetric constraints are needed to keep bothersome side effects low." @default.
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• W2113472764 date "2014-07-01" @default.
• W2113472764 modified "2023-10-16" @default.
• W2113472764 title "Dosimetric and patient correlates of quality of life after prostate stereotactic ablative radiotherapy" @default.
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• W2113472764 doi "https://doi.org/10.1016/j.radonc.2014.06.009" @default.
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