FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113485169> ?p ?o ?g. }

• W2113485169 endingPage "289" @default.
• W2113485169 startingPage "284" @default.
• W2113485169 abstract "The characteristics of adenosine and inosine outflow evoked by 5 min of ischemia-like conditions in vitro (superfusion with glucose-free Krebs solution gassed with 95% N2/5% CO2) were investigated on rat hippocampal slices. The viability of the slices after ischemia was evaluated by extracellular recording of the evoked synaptic responses in the CA1 region. The evoked dendritic field potentials were abolished after 5 min of superfusion under ischemia but a complete recovery occurred after 5 min of reperfusion with normal oxygenated Krebs solution. No recovery took place after 10 min of ischemia. The addition of the adenosine A1 receptor antagonist 8-phenyltheophylline to the superfusate antagonized the depression of the evoked field potentials caused by 5 min of ischemia. Five minutes of ischemia brought about a six- and fivefold increase in adenosine and inosine outflow, respectively, within 10 min. Tetrodotoxin reduced the outflow of adenosine and inosine by 42 and 33%, respectively, whereas the removal of Ca2+ caused a further increase. The NMDA receptor antagonist D(-)-2-amino-7-phosphonoheptanoic acid and the non-NMDA antagonist 6,7-dinitroquinoxaline-2,3-dione brought about small, not statistically significant decreases of adenosine and inosine outflow. The glutamate uptake inhibitor dihydrokainate did not affect the outflow of adenosine and inosine. Inhibition of ecto-5'-nucleotidase by alpha,beta-methylene ADP and GMP did not affect basal adenosine outflow but potentiated ischemia-evoked adenosine outflow. It is concluded that ischemia-like conditions in vitro evoke a Ca(2+)-independent adenosine and inosine outflow, through a mechanism that partly depends on propagated nervous activity but does not involve excitatory amino acids.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2113485169 created "2016-06-24" @default.
• W2113485169 creator A5013199489 @default.
• W2113485169 creator A5019494802 @default.
• W2113485169 creator A5025036324 @default.
• W2113485169 creator A5053047266 @default.
• W2113485169 date "1993-07-01" @default.
• W2113485169 modified "2023-10-18" @default.
• W2113485169 title "Investigations into the Adenosine Outflow from Hippocampal Slices Evoked by Ischemia-Like Conditions" @default.
• W2113485169 cites W1800555532 @default.
• W2113485169 cites W1899736663 @default.
• W2113485169 cites W1973293727 @default.
• W2113485169 cites W1975322631 @default.
• W2113485169 cites W1976423890 @default.
• W2113485169 cites W2001703551 @default.
• W2113485169 cites W2005781092 @default.
• W2113485169 cites W2015606837 @default.
• W2113485169 cites W2018703690 @default.
• W2113485169 cites W2020021319 @default.
• W2113485169 cites W2024207498 @default.
• W2113485169 cites W2026213310 @default.
• W2113485169 cites W2035997751 @default.
• W2113485169 cites W2038365695 @default.
• W2113485169 cites W2042991737 @default.
• W2113485169 cites W2046073222 @default.
• W2113485169 cites W2047193867 @default.
• W2113485169 cites W2049055914 @default.
• W2113485169 cites W2055991501 @default.
• W2113485169 cites W2057998065 @default.
• W2113485169 cites W2078848358 @default.
• W2113485169 cites W2080396236 @default.
• W2113485169 cites W2087921914 @default.
• W2113485169 cites W2096945682 @default.
• W2113485169 cites W2097744068 @default.
• W2113485169 cites W2104592058 @default.
• W2113485169 cites W2131347780 @default.
• W2113485169 cites W2134478550 @default.
• W2113485169 cites W2169129605 @default.
• W2113485169 cites W2441717400 @default.
• W2113485169 cites W2475553869 @default.
• W2113485169 cites W961682450 @default.
• W2113485169 doi "https://doi.org/10.1111/j.1471-4159.1993.tb03566.x" @default.
• W2113485169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8515275" @default.
• W2113485169 hasPublicationYear "1993" @default.
• W2113485169 type Work @default.
• W2113485169 sameAs 2113485169 @default.
• W2113485169 citedByCount "104" @default.
• W2113485169 countsByYear W21134851692012 @default.
• W2113485169 countsByYear W21134851692013 @default.
• W2113485169 countsByYear W21134851692014 @default.
• W2113485169 countsByYear W21134851692015 @default.
• W2113485169 countsByYear W21134851692016 @default.
• W2113485169 countsByYear W21134851692017 @default.
• W2113485169 countsByYear W21134851692018 @default.
• W2113485169 countsByYear W21134851692020 @default.
• W2113485169 countsByYear W21134851692021 @default.
• W2113485169 countsByYear W21134851692022 @default.
• W2113485169 crossrefType "journal-article" @default.
• W2113485169 hasAuthorship W2113485169A5013199489 @default.
• W2113485169 hasAuthorship W2113485169A5019494802 @default.
• W2113485169 hasAuthorship W2113485169A5025036324 @default.
• W2113485169 hasAuthorship W2113485169A5053047266 @default.
• W2113485169 hasConcept C126322002 @default.
• W2113485169 hasConcept C134018914 @default.
• W2113485169 hasConcept C170493617 @default.
• W2113485169 hasConcept C182683403 @default.
• W2113485169 hasConcept C185592680 @default.
• W2113485169 hasConcept C2776741303 @default.
• W2113485169 hasConcept C2776991684 @default.
• W2113485169 hasConcept C2777610669 @default.
• W2113485169 hasConcept C2778938600 @default.
• W2113485169 hasConcept C42219234 @default.
• W2113485169 hasConcept C541997718 @default.
• W2113485169 hasConcept C55493867 @default.
• W2113485169 hasConcept C61174792 @default.
• W2113485169 hasConcept C67018056 @default.
• W2113485169 hasConcept C67907053 @default.
• W2113485169 hasConcept C71924100 @default.
• W2113485169 hasConcept C86803240 @default.
• W2113485169 hasConcept C98274493 @default.
• W2113485169 hasConceptScore W2113485169C126322002 @default.
• W2113485169 hasConceptScore W2113485169C134018914 @default.
• W2113485169 hasConceptScore W2113485169C170493617 @default.
• W2113485169 hasConceptScore W2113485169C182683403 @default.
• W2113485169 hasConceptScore W2113485169C185592680 @default.
• W2113485169 hasConceptScore W2113485169C2776741303 @default.
• W2113485169 hasConceptScore W2113485169C2776991684 @default.
• W2113485169 hasConceptScore W2113485169C2777610669 @default.
• W2113485169 hasConceptScore W2113485169C2778938600 @default.
• W2113485169 hasConceptScore W2113485169C42219234 @default.
• W2113485169 hasConceptScore W2113485169C541997718 @default.
• W2113485169 hasConceptScore W2113485169C55493867 @default.
• W2113485169 hasConceptScore W2113485169C61174792 @default.
• W2113485169 hasConceptScore W2113485169C67018056 @default.
• W2113485169 hasConceptScore W2113485169C67907053 @default.
• W2113485169 hasConceptScore W2113485169C71924100 @default.
• W2113485169 hasConceptScore W2113485169C86803240 @default.
• W2113485169 hasConceptScore W2113485169C98274493 @default.

• next