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• W2113507488 abstract "A constant degree of binding of quinidine to a red blood cell hemolysate preparation was found for a clinically significant range of concentrations at 37° using the methods of equilibrium dialysis and ultracentrifugation. By repeating the binding experiments at 37° but over a much wider range of quinidine concentrations, it was possible to calculate an association constant (252 liters/mole) and the apparent number of binding sites (1.54). Quinidine appeared to be bound to a single binding site. In another series of experiments performed at therapeutic levels and 37°, the competitive binding of quinidine was studied in the presence of red blood cell hemolysate and serum, each placed in individual compartments of a dialysis cell but separated by a semipermeable membrane. Following attainment of equilibrium, free drug was separated from bound drug by ultracentrifugation. Calculations indicated that slightly more than half of the drug was contained within the serum compartment." @default.
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• W2113507488 date "1974-08-01" @default.
• W2113507488 modified "2023-10-18" @default.
• W2113507488 title "Binding of Quinidine to a Red Blood Cell Hemolysate Preparation" @default.
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• W2113507488 doi "https://doi.org/10.1002/jps.2600630822" @default.
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