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• W2113514677 startingPage "796" @default.
• W2113514677 abstract "The US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS, formerly AERS) is a database that contains information on adverse event and medication error reports submitted to the FDA. Besides those from manufacturers, reports can be submitted from health care professionals and the public. The original system was started in 1969, but since the last major revision in 1997, reporting has markedly increased. Data mining algorithms have been developed for the quantitative detection of signals from such a large database, where a signal means a statistical association between a drug and an adverse event or a drug-associated adverse event, including the proportional reporting ratio (PRR), the reporting odds ratio (ROR), the information component (IC), and the empirical Bayes geometric mean (EBGM). A survey of our previous reports suggested that the ROR provided the highest number of signals, and the EBGM the lowest. Additionally, an analysis of warfarin-, aspirin- and clopidogrel-associated adverse events suggested that all EBGM-based signals were included in the PRR-based signals, and also in the IC- or ROR-based ones, and that the PRR- and IC-based signals were in the ROR-based ones. In this article, the latest information on this area is summarized for future pharmacoepidemiological studies and/or pharmacovigilance analyses." @default.
• W2113514677 created "2016-06-24" @default.
• W2113514677 creator A5017404589 @default.
• W2113514677 creator A5041584550 @default.
• W2113514677 creator A5046211758 @default.
• W2113514677 creator A5053971924 @default.
• W2113514677 date "2013-01-01" @default.
• W2113514677 modified "2023-10-10" @default.
• W2113514677 title "Data Mining of the Public Version of the FDA Adverse Event Reporting System" @default.
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