Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113524447> ?p ?o ?g. }
- W2113524447 endingPage "83" @default.
- W2113524447 startingPage "70" @default.
- W2113524447 abstract "The field of cytochrome P450 (P450) research has developed considerably over the past 20 years, and many important papers on the roles of P450s in chemical toxicology have appeared in Chemical Research in Toxicology. Today, our basic understanding of many of the human P450s is relatively well-established, in terms of the details of the individual genes, sequences, and basic catalytic mechanisms. Crystal structures of several of the major human P450s are now in hand. The animal P450s are still important in the context of metabolism and safety testing. Many well-defined examples exist for roles of P450s in decreasing the adverse effects of drugs through biotransformation, and an equally interesting field of investigation is the bioactivation of chemicals, including drugs. Unresolved problems include the characterization of the minor “orphan” P450s, ligand cooperativity and kinetic complexity of several P450s, the prediction of metabolism, the overall contribution of bioactivation to drug idiosyncratic problems, the extrapolation of animal test results to humans in drug development, and the contribution of genetic variation in human P450s to cancer incidence." @default.
- W2113524447 created "2016-06-24" @default.
- W2113524447 creator A5058389506 @default.
- W2113524447 date "2007-12-06" @default.
- W2113524447 modified "2023-10-16" @default.
- W2113524447 title "Cytochrome P450 and Chemical Toxicology" @default.
- W2113524447 cites W1004452157 @default.
- W2113524447 cites W1498584605 @default.
- W2113524447 cites W1516077580 @default.
- W2113524447 cites W1520965071 @default.
- W2113524447 cites W1522002051 @default.
- W2113524447 cites W1544140936 @default.
- W2113524447 cites W1555802847 @default.
- W2113524447 cites W1575374956 @default.
- W2113524447 cites W1583125800 @default.
- W2113524447 cites W1603225698 @default.
- W2113524447 cites W1673905022 @default.
- W2113524447 cites W1695747683 @default.
- W2113524447 cites W1827138247 @default.
- W2113524447 cites W1860140559 @default.
- W2113524447 cites W1895993106 @default.
- W2113524447 cites W1923129209 @default.
- W2113524447 cites W1964858323 @default.
- W2113524447 cites W1966666947 @default.
- W2113524447 cites W1968583106 @default.
- W2113524447 cites W1972555033 @default.
- W2113524447 cites W1975206909 @default.
- W2113524447 cites W1981514978 @default.
- W2113524447 cites W1981728282 @default.
- W2113524447 cites W1982584241 @default.
- W2113524447 cites W1984939504 @default.
- W2113524447 cites W1986249226 @default.
- W2113524447 cites W1986304434 @default.
- W2113524447 cites W1989435868 @default.
- W2113524447 cites W1990928842 @default.
- W2113524447 cites W1991007539 @default.
- W2113524447 cites W1991231974 @default.
- W2113524447 cites W1992475241 @default.
- W2113524447 cites W1994235174 @default.
- W2113524447 cites W1995754186 @default.
- W2113524447 cites W1997029857 @default.
- W2113524447 cites W1998342457 @default.
- W2113524447 cites W1998491685 @default.
- W2113524447 cites W2001859397 @default.
- W2113524447 cites W2002301710 @default.
- W2113524447 cites W2002497805 @default.
- W2113524447 cites W2003946693 @default.
- W2113524447 cites W2004678494 @default.
- W2113524447 cites W2006931469 @default.
- W2113524447 cites W2009470576 @default.
- W2113524447 cites W2013331166 @default.
- W2113524447 cites W2014919794 @default.
- W2113524447 cites W2015221530 @default.
- W2113524447 cites W2019337449 @default.
- W2113524447 cites W2020756171 @default.
- W2113524447 cites W2021232512 @default.
- W2113524447 cites W2021842042 @default.
- W2113524447 cites W2026117122 @default.
- W2113524447 cites W2026195203 @default.
- W2113524447 cites W2026959257 @default.
- W2113524447 cites W2027928836 @default.
- W2113524447 cites W2028229016 @default.
- W2113524447 cites W2029255085 @default.
- W2113524447 cites W2029810628 @default.
- W2113524447 cites W2029986319 @default.
- W2113524447 cites W2030607204 @default.
- W2113524447 cites W2031172949 @default.
- W2113524447 cites W2031199981 @default.
- W2113524447 cites W2032335285 @default.
- W2113524447 cites W2033180524 @default.
- W2113524447 cites W2034125649 @default.
- W2113524447 cites W2034494912 @default.
- W2113524447 cites W2034950651 @default.
- W2113524447 cites W2035082685 @default.
- W2113524447 cites W2036504837 @default.
- W2113524447 cites W2037546651 @default.
- W2113524447 cites W2038951734 @default.
- W2113524447 cites W2040558033 @default.
- W2113524447 cites W2041073990 @default.
- W2113524447 cites W2041417337 @default.
- W2113524447 cites W2041544891 @default.
- W2113524447 cites W2042247296 @default.
- W2113524447 cites W2042619553 @default.
- W2113524447 cites W2042985281 @default.
- W2113524447 cites W2044462397 @default.
- W2113524447 cites W2044793333 @default.
- W2113524447 cites W2049770869 @default.
- W2113524447 cites W2051536602 @default.
- W2113524447 cites W2053293903 @default.
- W2113524447 cites W2058892921 @default.
- W2113524447 cites W2059045499 @default.
- W2113524447 cites W2059559580 @default.
- W2113524447 cites W2061944305 @default.
- W2113524447 cites W2062398703 @default.
- W2113524447 cites W2062893953 @default.
- W2113524447 cites W2062934575 @default.
- W2113524447 cites W2063249326 @default.
- W2113524447 cites W2063611241 @default.