FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113529168> ?p ?o ?g. }

• W2113529168 endingPage "3539" @default.
• W2113529168 startingPage "3534" @default.
• W2113529168 abstract "Bleomycin mediates cell wall damage in the yeast Saccharomyces cerevisiae. Bleomycin treatments in the presence of Fe(II) increased the rate of spheroplast formation by lytic enzymes by 5- to 40-fold. Neither Fe(III) nor other tested ions caused significant cell wall damage in the presence of bleomycin. The effect of bleomycin-Fe(II) on the cell wall mimicked the characteristics of bleomycin-Fe(II)-mediated DNA damage in dependence on aeration, inhibition by ascorbate, and potentiation by submillimolar concentrations of sodium phosphate. Bleomycin-mediated cell wall damage was time and dose dependent, with incubations as short as 20 min and drug concentrations as low as 3.3 x 10(-7)M causing measurable cell wall damage in strain CM1069-40. These times and concentrations are within the range of effectiveness for bleomycin-mediated DNA damage and for the cytotoxicity of the drug. Although Fe(III) was inactive with bleomycin and O2, the bleomycin-Fe(III) complex damaged walls and lysed cells in the presence of H2O2. H2O2 causes similar activation of bleomycin-Fe(III) in assays of DNA scission. These results suggest that an activated bleomycin-Fe-O2 complex disrupts essential cell wall polymers in a manner analogous to bleomycin-mediated cleavage of DNA." @default.
• W2113529168 created "2016-06-24" @default.
• W2113529168 creator A5028349963 @default.
• W2113529168 creator A5053803940 @default.
• W2113529168 creator A5056127368 @default.
• W2113529168 creator A5083764401 @default.
• W2113529168 date "1995-06-01" @default.
• W2113529168 modified "2023-10-13" @default.
• W2113529168 title "Oxidative cell wall damage mediated by bleomycin-Fe(II) in Saccharomyces cerevisiae" @default.
• W2113529168 cites W1010633374 @default.
• W2113529168 cites W1489316039 @default.
• W2113529168 cites W1501511167 @default.
• W2113529168 cites W1501768642 @default.
• W2113529168 cites W1518444464 @default.
• W2113529168 cites W1521817136 @default.
• W2113529168 cites W1521920054 @default.
• W2113529168 cites W1526215777 @default.
• W2113529168 cites W1592273056 @default.
• W2113529168 cites W1678772685 @default.
• W2113529168 cites W1695312621 @default.
• W2113529168 cites W1859189971 @default.
• W2113529168 cites W1904671412 @default.
• W2113529168 cites W1964548381 @default.
• W2113529168 cites W1978023597 @default.
• W2113529168 cites W1990706004 @default.
• W2113529168 cites W1991748528 @default.
• W2113529168 cites W2005875106 @default.
• W2113529168 cites W2013378424 @default.
• W2113529168 cites W2014732005 @default.
• W2113529168 cites W2025553609 @default.
• W2113529168 cites W2033518938 @default.
• W2113529168 cites W2034198381 @default.
• W2113529168 cites W2034266416 @default.
• W2113529168 cites W2038964687 @default.
• W2113529168 cites W2046900004 @default.
• W2113529168 cites W2057986820 @default.
• W2113529168 cites W2065291149 @default.
• W2113529168 cites W2067607091 @default.
• W2113529168 cites W2068250354 @default.
• W2113529168 cites W2075249158 @default.
• W2113529168 cites W2075632285 @default.
• W2113529168 cites W2083500807 @default.
• W2113529168 cites W2084306261 @default.
• W2113529168 cites W2090318060 @default.
• W2113529168 cites W2096179261 @default.
• W2113529168 cites W2102222957 @default.
• W2113529168 cites W2109461472 @default.
• W2113529168 cites W2116322023 @default.
• W2113529168 cites W2130316063 @default.
• W2113529168 cites W2171380556 @default.
• W2113529168 cites W28829384 @default.
• W2113529168 cites W2951883412 @default.
• W2113529168 doi "https://doi.org/10.1128/jb.177.12.3534-3539.1995" @default.
• W2113529168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/177059" @default.
• W2113529168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7539421" @default.
• W2113529168 hasPublicationYear "1995" @default.
• W2113529168 type Work @default.
• W2113529168 sameAs 2113529168 @default.
• W2113529168 citedByCount "26" @default.
• W2113529168 countsByYear W21135291682012 @default.
• W2113529168 countsByYear W21135291682014 @default.
• W2113529168 countsByYear W21135291682016 @default.
• W2113529168 countsByYear W21135291682018 @default.
• W2113529168 countsByYear W21135291682019 @default.
• W2113529168 countsByYear W21135291682020 @default.
• W2113529168 countsByYear W21135291682022 @default.
• W2113529168 crossrefType "journal-article" @default.
• W2113529168 hasAuthorship W2113529168A5028349963 @default.
• W2113529168 hasAuthorship W2113529168A5053803940 @default.
• W2113529168 hasAuthorship W2113529168A5056127368 @default.
• W2113529168 hasAuthorship W2113529168A5083764401 @default.
• W2113529168 hasBestOaLocation W21135291682 @default.
• W2113529168 hasConcept C125235067 @default.
• W2113529168 hasConcept C12554922 @default.
• W2113529168 hasConcept C143425029 @default.
• W2113529168 hasConcept C153911025 @default.
• W2113529168 hasConcept C2776232574 @default.
• W2113529168 hasConcept C2776694085 @default.
• W2113529168 hasConcept C2777576037 @default.
• W2113529168 hasConcept C2779222958 @default.
• W2113529168 hasConcept C54355233 @default.
• W2113529168 hasConcept C552990157 @default.
• W2113529168 hasConcept C55493867 @default.
• W2113529168 hasConcept C57409179 @default.
• W2113529168 hasConcept C86803240 @default.
• W2113529168 hasConceptScore W2113529168C125235067 @default.
• W2113529168 hasConceptScore W2113529168C12554922 @default.
• W2113529168 hasConceptScore W2113529168C143425029 @default.
• W2113529168 hasConceptScore W2113529168C153911025 @default.
• W2113529168 hasConceptScore W2113529168C2776232574 @default.
• W2113529168 hasConceptScore W2113529168C2776694085 @default.
• W2113529168 hasConceptScore W2113529168C2777576037 @default.
• W2113529168 hasConceptScore W2113529168C2779222958 @default.
• W2113529168 hasConceptScore W2113529168C54355233 @default.
• W2113529168 hasConceptScore W2113529168C552990157 @default.
• W2113529168 hasConceptScore W2113529168C55493867 @default.
• W2113529168 hasConceptScore W2113529168C57409179 @default.
• W2113529168 hasConceptScore W2113529168C86803240 @default.

• next