Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113534863> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2113534863 abstract "Streptococcus pneumoniae is one of the most important pathogen in childhood. We explored different aspects of immune responses to S. pneumoniae to better understand how natural protection against the disease is performed. The ultimate goal is to find diagnostic procedures to recognize pneumococcal disease in children, but also to identify strategies to protect children against S. pneumoniae, especially those at risk for severe disease. Hypothesis I Pneumococcal surface proteins- which act in vivo as virulence factors of S. pneumoniae- elicit immunogenic responses in children and can therefore be used for diagnostic purposes. This seroresponse may protect children against future disease. Methods I Seroresponses to different pneumococcal surface proteins were examined in different settings: A) In healthy young children B) In young children with pneumococcal bacteremia C) In children with community-acquired pneumonia Results I A) In healthy young children, we showed that antibodies against PcpA were measured at a younger age than against PhtD or PrtA, showing a distinct pattern for each pneumococcal surface protein. In addition, nasopharyngeal carriage played a significant role in producing higher antibody concentrations. B) In bacteremic young children, seroresponses was elicited in only approximately 50% of children. Younger children even showed an antibody-depleting effect after their disease. Serology-based diagnosis in young children is therefore unreliable. C) Low anti-PcpA antibody responses in the acute phase suggested a primary episode of pneumococcal disease. Its protective function is however not known. A combination of several pneumococcal surface proteins' seroresponses increased the likelihood of diagnosing community-acquired pneumococcal pneumonia. Hypothesis II Immunocompromised children can produce serotype-specific pneumococcal antibodies following vaccination. Methods II Iatrogenically immunocompromised children- pediatric orthotopic liver transplant recipients-were immunized against S. pneumoniae and their serotype-specific antibody levels measured. Results II Most liver transplanted children were able to produce protective antibody levels against S. pneumoniae, even while immunocompromised. Hypothesis III Children with recurrent lower respiratory tract infections due mostly to S. pneumoniae have a delayed or impaired maturation of their memory B cell compartment. Methods III We compared the B cell compartment and its function in children with recurrent lower respiratory tract infection and in healthy age-matched pediatric controls. Results III The memory B cell compartment, including subtypes, such as switched and IgM memory B cells were already constituted at two years of age in both groups, and could not explain the increased risk for pneumococcal infection." @default.
- W2113534863 created "2016-06-24" @default.
- W2113534863 creator A5040046423 @default.
- W2113534863 creator A5057164556 @default.
- W2113534863 date "2011-01-01" @default.
- W2113534863 modified "2023-09-25" @default.
- W2113534863 title "Response to pneumococcal infection or vaccination in immunocompetent and immunocompromised children" @default.
- W2113534863 doi "https://doi.org/10.13097/archive-ouverte/unige:17369" @default.
- W2113534863 hasPublicationYear "2011" @default.
- W2113534863 type Work @default.
- W2113534863 sameAs 2113534863 @default.
- W2113534863 citedByCount "0" @default.
- W2113534863 crossrefType "dissertation" @default.
- W2113534863 hasAuthorship W2113534863A5040046423 @default.
- W2113534863 hasAuthorship W2113534863A5057164556 @default.
- W2113534863 hasConcept C126322002 @default.
- W2113534863 hasConcept C159654299 @default.
- W2113534863 hasConcept C203014093 @default.
- W2113534863 hasConcept C22070199 @default.
- W2113534863 hasConcept C2776088486 @default.
- W2113534863 hasConcept C2776102371 @default.
- W2113534863 hasConcept C2776152631 @default.
- W2113534863 hasConcept C2777914695 @default.
- W2113534863 hasConcept C2779134260 @default.
- W2113534863 hasConcept C2779301066 @default.
- W2113534863 hasConcept C2779443120 @default.
- W2113534863 hasConcept C2779892413 @default.
- W2113534863 hasConcept C2781253189 @default.
- W2113534863 hasConcept C45189115 @default.
- W2113534863 hasConcept C501593827 @default.
- W2113534863 hasConcept C71924100 @default.
- W2113534863 hasConcept C86803240 @default.
- W2113534863 hasConcept C8891405 @default.
- W2113534863 hasConcept C89423630 @default.
- W2113534863 hasConceptScore W2113534863C126322002 @default.
- W2113534863 hasConceptScore W2113534863C159654299 @default.
- W2113534863 hasConceptScore W2113534863C203014093 @default.
- W2113534863 hasConceptScore W2113534863C22070199 @default.
- W2113534863 hasConceptScore W2113534863C2776088486 @default.
- W2113534863 hasConceptScore W2113534863C2776102371 @default.
- W2113534863 hasConceptScore W2113534863C2776152631 @default.
- W2113534863 hasConceptScore W2113534863C2777914695 @default.
- W2113534863 hasConceptScore W2113534863C2779134260 @default.
- W2113534863 hasConceptScore W2113534863C2779301066 @default.
- W2113534863 hasConceptScore W2113534863C2779443120 @default.
- W2113534863 hasConceptScore W2113534863C2779892413 @default.
- W2113534863 hasConceptScore W2113534863C2781253189 @default.
- W2113534863 hasConceptScore W2113534863C45189115 @default.
- W2113534863 hasConceptScore W2113534863C501593827 @default.
- W2113534863 hasConceptScore W2113534863C71924100 @default.
- W2113534863 hasConceptScore W2113534863C86803240 @default.
- W2113534863 hasConceptScore W2113534863C8891405 @default.
- W2113534863 hasConceptScore W2113534863C89423630 @default.
- W2113534863 hasLocation W21135348631 @default.
- W2113534863 hasOpenAccess W2113534863 @default.
- W2113534863 hasPrimaryLocation W21135348631 @default.
- W2113534863 hasRelatedWork W1523526271 @default.
- W2113534863 hasRelatedWork W2014395715 @default.
- W2113534863 hasRelatedWork W2104353241 @default.
- W2113534863 hasRelatedWork W2107442199 @default.
- W2113534863 hasRelatedWork W2111011662 @default.
- W2113534863 hasRelatedWork W2151430636 @default.
- W2113534863 hasRelatedWork W2153538372 @default.
- W2113534863 hasRelatedWork W2157739090 @default.
- W2113534863 hasRelatedWork W2165961510 @default.
- W2113534863 hasRelatedWork W2168379509 @default.
- W2113534863 hasRelatedWork W2411933263 @default.
- W2113534863 hasRelatedWork W2495077342 @default.
- W2113534863 hasRelatedWork W2590010111 @default.
- W2113534863 hasRelatedWork W2766425633 @default.
- W2113534863 hasRelatedWork W2900979748 @default.
- W2113534863 hasRelatedWork W3004977688 @default.
- W2113534863 hasRelatedWork W3037653764 @default.
- W2113534863 hasRelatedWork W3165528257 @default.
- W2113534863 hasRelatedWork W3170325401 @default.
- W2113534863 hasRelatedWork W2409951951 @default.
- W2113534863 isParatext "false" @default.
- W2113534863 isRetracted "false" @default.
- W2113534863 magId "2113534863" @default.
- W2113534863 workType "dissertation" @default.