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- W2113536555 abstract "To determine if estrogen upregulates osmotic secretion of arginine vasopressin (AVP) and alters body water balance, we infused hypertonic (3% NaCl) saline in 6 women (68 ± 3 yr) after 14 days of 17β-estradiol (transdermal patch, ∼0.1 mg/day, E 2 ) and placebo (control) administration. Hypertonic saline was infused at 0.1 ml ⋅ kg −1 ⋅ min −1 for 120 min, and after a 30-min equilibration period, the subjects drank water ad libitum for 180 min. E 2 increased basal plasma estradiol concentration from ≤12 to 80 ± 12 pg/ml and plasma AVP concentration (P [AVP] ) from 2.1 ± 0.7 to 3.1 ± 0.8 pg/ml ( P< 0.05), but not plasma osmolality (P osm , 288 ± 1 and 287 ± 1, for control and E 2 , respectively). Hypertonic saline infusion increased P osm by 18 ± 1 and 17 ± 1 mosmol/kgH 2 O and P [AVP] by 5.2 ± 0.5 and 4.9 ± 0.4 pg/ml for control and E 2 treatments, respectively. The P [AVP] -P osm relationship shifted upward after E 2 , with no change in sensitivity (slope, 0.36 ± 0.02 and 0.33 ± 0.03 pg ⋅ ml −1 ⋅ mosmol −1 for control and E 2 , respectively). Water intake was similar between control and E 2 (24 vs. 22 ml/kg), but by 180 min of drinking, urine output and free water clearance ([Formula: see text]) were reduced by 5.6 ± 2.3 ml/kg and 2.6 ± 2.0 ml/min, respectively ( P < 0.05) after E 2 . Plasma aldosterone concentration was unaffected by E 2 , but fractional sodium excretion was reduced from 2.7 ± 0.5 to 1.7 ± 0.4% ( P < 0.05) at 180 min of drinking. Our data suggest that E 2 augments osmotic AVP secretion, thereby implicating elevated AVP as a contributor to water retention in high E 2 states; however, an increase in renal sodium reabsorption was a major component of the enhanced fluid retention." @default.
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- W2113536555 date "1998-01-01" @default.
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- W2113536555 title "Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women" @default.
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- W2113536555 doi "https://doi.org/10.1152/ajpregu.1998.274.1.r187" @default.
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