FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113553405> ?p ?o ?g. }

• W2113553405 endingPage "64" @default.
• W2113553405 startingPage "60" @default.
• W2113553405 abstract "The C ‐terminal cytoplasmic tails of claudins are likely sites for interaction with proteins that regulate their function. We performed a yeast two‐hybrid screen with the tail of human claudin‐2 against a human kidney cDNA library and identified interactions with the PDZ3 domain of ZO‐2 as well as ubiquitin‐conjugating enzyme E2I (SUMO ligase‐1) and E3 SUMO‐protein ligase PIAS; the first is a predicted interaction, while the latter two are novel and suggest that claudin‐2 is a substrate for SUMOylation. Using an in vitro SUMOylation assay, we identified K218 as a conjugation site on claudin‐2; mutation of that lysine to arginine blocked SUMOylation. Stable expression of inducible GFP‐SUMO‐1 in MDCK cells resulted in decreased levels of claudin‐2 protein by immunoblot and decreased claudin‐2 membrane expression by immunofluorescence microscopy. We conclude that the cellular levels of claudin‐2 may be modulated by SUMOylation, warranting further investigation of cellular pathways that regulate this modification in vivo ." @default.
• W2113553405 created "2016-06-24" @default.
• W2113553405 creator A5024216881 @default.
• W2113553405 creator A5058206397 @default.
• W2113553405 creator A5059725025 @default.
• W2113553405 date "2012-06-25" @default.
• W2113553405 modified "2023-10-11" @default.
• W2113553405 title "SUMOylation of claudin‐2" @default.
• W2113553405 cites W1653383134 @default.
• W2113553405 cites W1973480232 @default.
• W2113553405 cites W1993180829 @default.
• W2113553405 cites W1995456120 @default.
• W2113553405 cites W2001029086 @default.
• W2113553405 cites W2002148906 @default.
• W2113553405 cites W2013108773 @default.
• W2113553405 cites W2022715234 @default.
• W2113553405 cites W2024935012 @default.
• W2113553405 cites W2031668046 @default.
• W2113553405 cites W2040509610 @default.
• W2113553405 cites W2046037983 @default.
• W2113553405 cites W2051580248 @default.
• W2113553405 cites W2051961867 @default.
• W2113553405 cites W2057861732 @default.
• W2113553405 cites W2083312621 @default.
• W2113553405 cites W2092582603 @default.
• W2113553405 cites W2094741094 @default.
• W2113553405 cites W2105196805 @default.
• W2113553405 cites W2111937069 @default.
• W2113553405 cites W2116901311 @default.
• W2113553405 cites W2117070336 @default.
• W2113553405 cites W2139960392 @default.
• W2113553405 cites W2143112755 @default.
• W2113553405 doi "https://doi.org/10.1111/j.1749-6632.2012.06541.x" @default.
• W2113553405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22731716" @default.
• W2113553405 hasPublicationYear "2012" @default.
• W2113553405 type Work @default.
• W2113553405 sameAs 2113553405 @default.
• W2113553405 citedByCount "29" @default.
• W2113553405 countsByYear W21135534052013 @default.
• W2113553405 countsByYear W21135534052014 @default.
• W2113553405 countsByYear W21135534052015 @default.
• W2113553405 countsByYear W21135534052016 @default.
• W2113553405 countsByYear W21135534052017 @default.
• W2113553405 countsByYear W21135534052018 @default.
• W2113553405 countsByYear W21135534052019 @default.
• W2113553405 countsByYear W21135534052020 @default.
• W2113553405 countsByYear W21135534052021 @default.
• W2113553405 countsByYear W21135534052022 @default.
• W2113553405 countsByYear W21135534052023 @default.
• W2113553405 crossrefType "journal-article" @default.
• W2113553405 hasAuthorship W2113553405A5024216881 @default.
• W2113553405 hasAuthorship W2113553405A5058206397 @default.
• W2113553405 hasAuthorship W2113553405A5059725025 @default.
• W2113553405 hasBestOaLocation W21135534052 @default.
• W2113553405 hasConcept C104317684 @default.
• W2113553405 hasConcept C134459356 @default.
• W2113553405 hasConcept C153911025 @default.
• W2113553405 hasConcept C154428179 @default.
• W2113553405 hasConcept C171350616 @default.
• W2113553405 hasConcept C175114707 @default.
• W2113553405 hasConcept C177779419 @default.
• W2113553405 hasConcept C181199279 @default.
• W2113553405 hasConcept C185592680 @default.
• W2113553405 hasConcept C186055190 @default.
• W2113553405 hasConcept C187882448 @default.
• W2113553405 hasConcept C190062978 @default.
• W2113553405 hasConcept C24284526 @default.
• W2113553405 hasConcept C25602115 @default.
• W2113553405 hasConcept C51872919 @default.
• W2113553405 hasConcept C54009773 @default.
• W2113553405 hasConcept C54355233 @default.
• W2113553405 hasConcept C55493867 @default.
• W2113553405 hasConcept C71829478 @default.
• W2113553405 hasConcept C81885089 @default.
• W2113553405 hasConcept C86339819 @default.
• W2113553405 hasConcept C86803240 @default.
• W2113553405 hasConcept C95444343 @default.
• W2113553405 hasConceptScore W2113553405C104317684 @default.
• W2113553405 hasConceptScore W2113553405C134459356 @default.
• W2113553405 hasConceptScore W2113553405C153911025 @default.
• W2113553405 hasConceptScore W2113553405C154428179 @default.
• W2113553405 hasConceptScore W2113553405C171350616 @default.
• W2113553405 hasConceptScore W2113553405C175114707 @default.
• W2113553405 hasConceptScore W2113553405C177779419 @default.
• W2113553405 hasConceptScore W2113553405C181199279 @default.
• W2113553405 hasConceptScore W2113553405C185592680 @default.
• W2113553405 hasConceptScore W2113553405C186055190 @default.
• W2113553405 hasConceptScore W2113553405C187882448 @default.
• W2113553405 hasConceptScore W2113553405C190062978 @default.
• W2113553405 hasConceptScore W2113553405C24284526 @default.
• W2113553405 hasConceptScore W2113553405C25602115 @default.
• W2113553405 hasConceptScore W2113553405C51872919 @default.
• W2113553405 hasConceptScore W2113553405C54009773 @default.
• W2113553405 hasConceptScore W2113553405C54355233 @default.
• W2113553405 hasConceptScore W2113553405C55493867 @default.
• W2113553405 hasConceptScore W2113553405C71829478 @default.
• W2113553405 hasConceptScore W2113553405C81885089 @default.
• W2113553405 hasConceptScore W2113553405C86339819 @default.

• next