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- W2113562421 abstract "To obviate the lack of injectable quinine in a hospital in rural Burundi, mefloquine, only available as an oral formulation, was administered (25 mg/kg bodyweight) as a single dose by nasogastric tube to four small children with cerebral malaria. All patients recovered uneventfully after a mean coma duration of 20.5 h. Mefloquine was rapidly absorbed and therapeutic serum concentrations were achieved within a few hours in all subjects, with parasite reduction ratios after 48 h within the expected range for drug-sensitive parasites. These findings suggest that intragastric mefloquine deserves consideration whenever parenteral drugs are not available for the treatment of cerebral malaria." @default.
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- W2113562421 date "1999-10-01" @default.
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- W2113562421 title "Rapid absorption and clinical effectiveness of intragastric mefloquine in the treament of cerebral malaria in African children" @default.
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- W2113562421 doi "https://doi.org/10.1093/jac/44.4.573" @default.
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