FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113565145> ?p ?o ?g. }

• W2113565145 endingPage "5811" @default.
• W2113565145 startingPage "5801" @default.
• W2113565145 abstract "Abstract Purpose: Inherited variability in the prognosis of lung cancer patients treated with platinum-based chemotherapy has been widely investigated. However, the overall contribution of genetic variation to platinum response is not well established. To identify novel candidate single nucleotide polymorphisms (SNP)/genes, we carried out a genome-wide association study (GWAS) for cisplatin cytotoxicity by using lymphoblastoid cell lines (LCL), followed by an association study of selected SNPs from the GWAS with overall survival (OS) in lung cancer patients. Experimental Design: A GWAS for cisplatin was conducted with 283 ethnically diverse LCLs. A total of 168 top SNPs were genotyped in 222 small cell lung cancer (SCLC) and 961 non-SCLC (NSCLC) patients treated with platinum-based therapy. Association of the SNPs with OS was determined by using the Cox regression model. Selected candidate genes were functionally validated by siRNA knockdown in human lung cancer cells. Results: Among 157 successfully genotyped SNPs, 9 and 10 SNPs were top SNPs associated with OS for patients with NSCLC and SCLC, respectively, although they were not significant after adjusting for multiple testing. Fifteen genes, including 7 located within 200 kb up or downstream of the 4 top SNPs and 8 genes for which expression was correlated with 3 SNPs in LCLs were selected for siRNA screening. Knockdown of DAPK3 and METTL6, for which expression levels were correlated with the rs11169748 and rs2440915 SNPs, significantly decreased cisplatin sensitivity in lung cancer cells. Conclusions: This series of clinical and complementary laboratory-based functional studies identified several candidate genes/SNPs that might help predict treatment outcomes for platinum-based therapy of lung cancer. Clin Cancer Res; 17(17); 5801–11. ©2011 AACR." @default.
• W2113565145 created "2016-06-24" @default.
• W2113565145 creator A5004055647 @default.
• W2113565145 creator A5004264491 @default.
• W2113565145 creator A5011038911 @default.
• W2113565145 creator A5025452176 @default.
• W2113565145 creator A5035259692 @default.
• W2113565145 creator A5037484104 @default.
• W2113565145 creator A5038581416 @default.
• W2113565145 creator A5049576378 @default.
• W2113565145 creator A5064564309 @default.
• W2113565145 creator A5067865294 @default.
• W2113565145 creator A5069578729 @default.
• W2113565145 creator A5074877527 @default.
• W2113565145 creator A5086376470 @default.
• W2113565145 date "2011-09-01" @default.
• W2113565145 modified "2023-10-07" @default.
• W2113565145 title "Genetic Variation Predicting Cisplatin Cytotoxicity Associated with Overall Survival in Lung Cancer Patients Receiving Platinum-Based Chemotherapy" @default.
• W2113565145 cites W1788133348 @default.
• W2113565145 cites W1976843725 @default.
• W2113565145 cites W1994214112 @default.
• W2113565145 cites W2007629457 @default.
• W2113565145 cites W2008937886 @default.
• W2113565145 cites W2013550458 @default.
• W2113565145 cites W2021825157 @default.
• W2113565145 cites W2028395388 @default.
• W2113565145 cites W2042556118 @default.
• W2113565145 cites W2054354127 @default.
• W2113565145 cites W2059584703 @default.
• W2113565145 cites W2066894862 @default.
• W2113565145 cites W2067245109 @default.
• W2113565145 cites W2067551453 @default.
• W2113565145 cites W2081872599 @default.
• W2113565145 cites W2087755904 @default.
• W2113565145 cites W2090808827 @default.
• W2113565145 cites W2104265571 @default.
• W2113565145 cites W2106953938 @default.
• W2113565145 cites W2113304916 @default.
• W2113565145 cites W2116521204 @default.
• W2113565145 cites W2118951956 @default.
• W2113565145 cites W2123526519 @default.
• W2113565145 cites W2127808743 @default.
• W2113565145 cites W2128218919 @default.
• W2113565145 cites W2132376916 @default.
• W2113565145 cites W2133539904 @default.
• W2113565145 cites W2134783591 @default.
• W2113565145 cites W2140105522 @default.
• W2113565145 cites W2145995826 @default.
• W2113565145 cites W2148070020 @default.
• W2113565145 cites W2152671743 @default.
• W2113565145 cites W2153507021 @default.
• W2113565145 cites W2156044891 @default.
• W2113565145 cites W2156613325 @default.
• W2113565145 cites W2157752701 @default.
• W2113565145 cites W2159241317 @default.
• W2113565145 cites W2165614511 @default.
• W2113565145 cites W2166501262 @default.
• W2113565145 cites W2168655513 @default.
• W2113565145 cites W2169416147 @default.
• W2113565145 cites W2171777347 @default.
• W2113565145 cites W4239714259 @default.
• W2113565145 cites W4242684160 @default.
• W2113565145 doi "https://doi.org/10.1158/1078-0432.ccr-11-1133" @default.
• W2113565145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3167019" @default.
• W2113565145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21775533" @default.
• W2113565145 hasPublicationYear "2011" @default.
• W2113565145 type Work @default.
• W2113565145 sameAs 2113565145 @default.
• W2113565145 citedByCount "90" @default.
• W2113565145 countsByYear W21135651452012 @default.
• W2113565145 countsByYear W21135651452013 @default.
• W2113565145 countsByYear W21135651452014 @default.
• W2113565145 countsByYear W21135651452015 @default.
• W2113565145 countsByYear W21135651452016 @default.
• W2113565145 countsByYear W21135651452017 @default.
• W2113565145 countsByYear W21135651452018 @default.
• W2113565145 countsByYear W21135651452019 @default.
• W2113565145 countsByYear W21135651452020 @default.
• W2113565145 countsByYear W21135651452021 @default.
• W2113565145 countsByYear W21135651452022 @default.
• W2113565145 countsByYear W21135651452023 @default.
• W2113565145 crossrefType "journal-article" @default.
• W2113565145 hasAuthorship W2113565145A5004055647 @default.
• W2113565145 hasAuthorship W2113565145A5004264491 @default.
• W2113565145 hasAuthorship W2113565145A5011038911 @default.
• W2113565145 hasAuthorship W2113565145A5025452176 @default.
• W2113565145 hasAuthorship W2113565145A5035259692 @default.
• W2113565145 hasAuthorship W2113565145A5037484104 @default.
• W2113565145 hasAuthorship W2113565145A5038581416 @default.
• W2113565145 hasAuthorship W2113565145A5049576378 @default.
• W2113565145 hasAuthorship W2113565145A5064564309 @default.
• W2113565145 hasAuthorship W2113565145A5067865294 @default.
• W2113565145 hasAuthorship W2113565145A5069578729 @default.
• W2113565145 hasAuthorship W2113565145A5074877527 @default.
• W2113565145 hasAuthorship W2113565145A5086376470 @default.
• W2113565145 hasBestOaLocation W21135651451 @default.
• W2113565145 hasConcept C104317684 @default.
• W2113565145 hasConcept C106208931 @default.

• next