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• W2113596951 abstract "ABSTRACT To study the organization of gap junctions in living cells, the connexin isotypes α1(Cx43), β1(Cx32) and β2(Cx26) were tagged with the autofluorescent tracer green fluorescent protein (GFP) and its cyan (CFP) and yellow (YFP) color variants. The cellular fate of the tagged connexins was followed by high-resolution fluorescence deconvolution microscopy and time-lapse imaging. Comprehensive analyses demonstrated that the tagged channels were functional as monitored by dye transfer, even under conditions where the channels were assembled solely from tagged connexins. High-resolution images revealed a detailed structural organization, and volume reconstructions provided a three-dimensional view of entire gap junction plaques. Specifically, deconvolved dual-color images of gap junction plaques assembled from CFP- and YFP-tagged connexins revealed that different connexin isotypes gathered within the same plaques. Connexins either codistributed homogeneously throughout the plaque, or each connexin isotype segregated into well-separated domains. The studies demonstrate that the mode of channel distribution strictly depends on the connexin isotypes. Based on previous studies on the synthesis and assembly of connexins I suggest that channel distribution is regulated by intrinsic connexin isotype specific signals. Movies available on-line: http://www.biologists.com/JCS/movies/jcs1735.html" @default.
• W2113596951 created "2016-06-24" @default.
• W2113596951 creator A5068759792 @default.
• W2113596951 date "2000-11-15" @default.
• W2113596951 modified "2023-10-09" @default.
• W2113596951 title "Connexin-specific distribution within gap junctions revealed in living cells" @default.
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• W2113596951 doi "https://doi.org/10.1242/jcs.113.22.4109" @default.
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