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• W2113607574 abstract "Since its first proposal in the late 1980s FDG-PET scan (and later on FDG-PET/CT scan) and lymphoma have become an indissoluble binomial. FDG-PET scan proves a very useful tool for Hodgkin (HL) and non-Hodgkin (NHL) lymphoma staging, restaging and prognostication and is essential for radiotherapy planning and chemosensitivity assessment in HL; the last-born offspring of this synergy has been the PET response-adapted strategy in HL and diffuse large B cell lymphoma (DLBCL). Thanks also to the contribution of PET scan in all these important steps of lymphoma management, the longterm lymphoma survivorship has increased overtime in the last two decades also in lymphoma subsets (elderly patients and HL) in which no major advances in treatment effectiveness could have account for this improvement. Onco-haematologists and nuclear medicine experts joined their efforts in several informal and international workshops dedicated to PET scan in lymphoma to standardize interim and end-of therapy PET scan reporting, proposing the so-called ‘‘Deauville five-point scale’’ or ‘‘Deauville rules’’, from the venue hosting the first meeting. The latter, in turn, has been incorporated in the lastborn criteria for lymphoma staging and restaging, the socalled Lugano criteria, which have definitely included FDG-PET scan in the armamentarium of the necessary imaging tools for assessing the tumour spread in FDG-avid lymphoma. In agreement with the organization committee of the International Conference on Malignant Lymphoma (ICML), which is held every other year in Lugano, the PET in lymphoma workshop is held every other year in Menton (France), interspersed with Lugano meetings. The cooperation between haematologists and nuclear medicine experts has been further tightened in the organization of dedicated courses for PET reporting in clinical trials based on PET imaging. The technological evolution of PET scanning equipment, the implementation of new software able to perform a semi-automatic reading of FDG concentrating lesions, the new metrics for quantitative PET scan (Q-PET) reading with SUV and derived parameters such as metabolic tumour volume (MTV) and total lesion glycolysis (TLG) have further widened the interdisciplinary cooperation, involving other categories of imaging experts: the medical physicists, the bioinformatics and the statisticians. The progress of bioinformatics has eased the imaging exchange for central review of scans and central handling and computing of Q-PET parameters. This in turn has opened new frontiers for international cooperation among cooperative groups in lymphoma, in the context of PETbased multicentre clinical trials. Finally, the new trends in personalized medicine have spurred the search for newer, more accurate tools for prognostication on a single-patient basis, and biomarkers have been recently integrated with imaging for the setup of newer prognostic model. For this reason, the galaxy of the expanding knowledge revolving around imaging has spurred an interdisciplinary approach needing dedicated channels of information. & Alberto Biggi biggi.a@ospedale.cuneo.it" @default.
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• W2113607574 date "2015-07-09" @default.
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• W2113607574 title "FDG-PET scan in lymphoma: silver anniversary" @default.
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• W2113607574 doi "https://doi.org/10.1007/s40336-015-0128-9" @default.
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