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- W2113608726 abstract "We earlier reported that stimulation of either one of the sympathetic and vagal nerves augments the dynamic heart rate (HR) response to concurrent stimulation of its counterpart. We explained this phenomenon by assuming a sigmoidal static relationship between nerve activity and HR. To confirm this assumption, we stimulated the sympathetic and/or vagal nerve in anesthetized rabbits using large-amplitude Gaussian white noise and determined the static and dynamic characteristics of HR regulation by a neural network analysis. The static characteristics approximated a sigmoidal relationship between the linearly predicted and the measured HRs (response range: 212.4 ± 46.3 beats/min, minimum HR: 96.0 ± 28.4 beats/min, midpoint of operation: 196.7 ± 31.3 beats/min, maximum slope: 1.65 ± 0.51). The maximum step responses determined from the dynamic characteristics were 7.9 ± 2.9 and −14.0 ± 4.9 beats ⋅ min −1 ⋅ Hz −1 for the sympathetic and the vagal system, respectively. Because of these characteristics, changes in sympathetic or vagal tone alone can alter the dynamic HR response to stimulation of the other nerve." @default.
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- W2113608726 date "1999-03-01" @default.
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- W2113608726 title "Simultaneous identification of static and dynamic vagosympathetic interactions in regulating heart rate" @default.
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- W2113608726 doi "https://doi.org/10.1152/ajpregu.1999.276.3.r782" @default.
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