Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113621941> ?p ?o ?g. }
- W2113621941 endingPage "13494" @default.
- W2113621941 startingPage "13482" @default.
- W2113621941 abstract "Abstract We describe 2‐mercaptopyridine‐ N ‐oxide (HSPNO) as a new and efficient competitive inhibitor of mushroom tyrosinase ( K IC =3.7 μ M ). Binding studies of HSPNO and 2‐hydroxypyridine‐ N ‐oxide (HOPNO) on dinuclear copper(II) complexes [Cu 2 (BPMP)(μ‐OH)](ClO 4 ) 2 ( 1 ; HBPMP=2,6‐bis[bis(2‐pyridylmethyl)aminomethyl]‐4‐methylphenol) and [Cu 2 (BPEP)(μ‐OH)](ClO 4 ) 2 ) ( 2 ; HBPEP=2,6‐bis{bis[2‐(2‐pyridyl)ethyl]aminomethyl}‐4‐methylphenol), known to be functional models for the tyrosinase diphenolase activity, have been performed. A combination of structural data, spectroscopic studies, and DFT calculations evidenced the adaptable binding mode (bridging versus chelating) of HOPNO in relation to the geometry and chelate size of the dicopper center. For comparison, binding studies of HSPNO and kojic acid (5‐hydroxy‐2‐(hydroxymethyl)‐4‐pyrone) on dinuclear complexes were performed. A theoretical approach has been developed and validated on HOPNO adducts to compare the binding mode on the model complexes. It has been applied for HSPNO and kojic acid. Although results for HSPNO were in line with those obtained with HOPNO, thus reflecting their chemical similarity, we showed that the bridging mode was the most preferential binding mode for kojic acid on both complexes." @default.
- W2113621941 created "2016-06-24" @default.
- W2113621941 creator A5004942564 @default.
- W2113621941 creator A5009072295 @default.
- W2113621941 creator A5009859055 @default.
- W2113621941 creator A5016253396 @default.
- W2113621941 creator A5025482032 @default.
- W2113621941 creator A5045944229 @default.
- W2113621941 creator A5047952947 @default.
- W2113621941 creator A5057626728 @default.
- W2113621941 creator A5063826667 @default.
- W2113621941 creator A5066601796 @default.
- W2113621941 creator A5070479979 @default.
- W2113621941 date "2011-10-25" @default.
- W2113621941 modified "2023-10-18" @default.
- W2113621941 title "The Versatile Binding Mode of Transition-State Analogue Inhibitors of Tyrosinase towards Dicopper(II) Model Complexes: Experimental and Theoretical Investigations" @default.
- W2113621941 cites W1511407547 @default.
- W2113621941 cites W1600025620 @default.
- W2113621941 cites W1602639107 @default.
- W2113621941 cites W1964047219 @default.
- W2113621941 cites W1964523164 @default.
- W2113621941 cites W1966235871 @default.
- W2113621941 cites W1971218701 @default.
- W2113621941 cites W1971275758 @default.
- W2113621941 cites W1974967324 @default.
- W2113621941 cites W1975165348 @default.
- W2113621941 cites W1984184890 @default.
- W2113621941 cites W1984220228 @default.
- W2113621941 cites W1987946870 @default.
- W2113621941 cites W1988888691 @default.
- W2113621941 cites W1991632645 @default.
- W2113621941 cites W1991690789 @default.
- W2113621941 cites W2005234903 @default.
- W2113621941 cites W2008553568 @default.
- W2113621941 cites W2008584788 @default.
- W2113621941 cites W2012213837 @default.
- W2113621941 cites W2012475237 @default.
- W2113621941 cites W2015495890 @default.
- W2113621941 cites W2016331364 @default.
- W2113621941 cites W2016580108 @default.
- W2113621941 cites W2022636958 @default.
- W2113621941 cites W2023271753 @default.
- W2113621941 cites W2024811628 @default.
- W2113621941 cites W2026594509 @default.
- W2113621941 cites W2036280402 @default.
- W2113621941 cites W2036524141 @default.
- W2113621941 cites W2041041109 @default.
- W2113621941 cites W2044151658 @default.
- W2113621941 cites W2045952721 @default.
- W2113621941 cites W2045996993 @default.
- W2113621941 cites W2046384097 @default.
- W2113621941 cites W2046817964 @default.
- W2113621941 cites W2060526159 @default.
- W2113621941 cites W2061344628 @default.
- W2113621941 cites W2061356043 @default.
- W2113621941 cites W2066223077 @default.
- W2113621941 cites W2071805371 @default.
- W2113621941 cites W2078975459 @default.
- W2113621941 cites W2079751966 @default.
- W2113621941 cites W2094642658 @default.
- W2113621941 cites W2095504229 @default.
- W2113621941 cites W2101265995 @default.
- W2113621941 cites W2102455520 @default.
- W2113621941 cites W2104484273 @default.
- W2113621941 cites W2120436453 @default.
- W2113621941 cites W2120851907 @default.
- W2113621941 cites W2132934971 @default.
- W2113621941 cites W2138520198 @default.
- W2113621941 cites W2143981217 @default.
- W2113621941 cites W2148941593 @default.
- W2113621941 cites W2149250648 @default.
- W2113621941 cites W2158113006 @default.
- W2113621941 cites W2170865436 @default.
- W2113621941 cites W2312288457 @default.
- W2113621941 cites W2319628733 @default.
- W2113621941 cites W2340940993 @default.
- W2113621941 cites W24870503 @default.
- W2113621941 cites W277762786 @default.
- W2113621941 cites W2951136847 @default.
- W2113621941 cites W3024461240 @default.
- W2113621941 cites W32632828 @default.
- W2113621941 cites W4237379548 @default.
- W2113621941 cites W4376043526 @default.
- W2113621941 cites W51577300 @default.
- W2113621941 doi "https://doi.org/10.1002/chem.201100665" @default.
- W2113621941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22025275" @default.
- W2113621941 hasPublicationYear "2011" @default.
- W2113621941 type Work @default.
- W2113621941 sameAs 2113621941 @default.
- W2113621941 citedByCount "11" @default.
- W2113621941 countsByYear W21136219412012 @default.
- W2113621941 countsByYear W21136219412013 @default.
- W2113621941 countsByYear W21136219412014 @default.
- W2113621941 countsByYear W21136219412016 @default.
- W2113621941 countsByYear W21136219412017 @default.
- W2113621941 countsByYear W21136219412018 @default.
- W2113621941 countsByYear W21136219412020 @default.
- W2113621941 countsByYear W21136219412023 @default.