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• W2113630892 abstract "If world oil prices dropped to zero next year, how would it change the world economy? Investments in oil field explorat ion would lose their value overnight, whereas shares in a factory making e n v i r o n m e n t a l l y f r iendly c o m b u s t i o n engines migh t go up. Everybody would feel the need to p lan ahead, and m a n y plans wou ld change. In genetics and molecular biology, DNA sequences are the fuel of research, and their prices are falling dramatical ly. Wi th in 5 years m a n y complete genomes will be sequenced, and sequence data will be like tap water in Amsterd a m e s s e n t i a l for life, but too cheap to measure. A project tha t was perfectly rational 2 years ago will be a total waste of t ime tomorrow, and projects that seemed impossible will become feasible. The aim of this review is to explore the consequences for biology of the wealth of DNA sequence data now becoming available. Several bacterial genomes have been sequenced already (Fleischmann et al. 1995; Fraser et al. 1995). The first an imal to feel these changes will be the n e m a t o d e Caenorhabditis elegans, a nd t h e worm will be the focus of this review. The virtues of C. elegans as a model system in biology have recently been sung elsewhere (Hodgkin et al. 1995). In brief, it does everything that makes life i n t e r e s t i n g (ea t ing , c o p u l a t i n g , g e t t i n g around, and relating to the envi ronment ) and manages to do so with only 959 cells, of which 302 form the brain. However, it is likely tha t much of what is said will apply equally to other species; thus, I hope that the review may also be of some interest outside of the C. elegans community." @default.
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• W2113630892 date "1996-03-01" @default.
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• W2113630892 title "Postsequence genetics of Caenorhabditis elegans." @default.
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• W2113630892 doi "https://doi.org/10.1101/gr.6.3.169" @default.
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