Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113646768> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2113646768 endingPage "67" @default.
- W2113646768 startingPage "57" @default.
- W2113646768 abstract "The profile of immunologically active human luteinizing hormone (hLH) was determined in aqueous pituitary extracts after electrofocusing using two radioimmunoassay systems and the estimates for each fraction were compared to those obtained by an in vitro bioassay method. Similar biological and immunological profiles were obtained in the pH 7.0–9.0 region, where most of the biological activity was present. Biological to immunological (B/I) ratios ranging from 0.6 to 1.7 (mean ratio 1.01; n = 21) were found in the major biologically active fractions of this pH region when a highly purified human pituitary LH preparation (68/40) was used as standard in both types of assays. The close proximity of these ratios to unity indicates a similar composition of biological and immunological activities in all these fractions in relation to that of the highly purified standard. However, marked discrepancies were observed in the pH region 3.0–7.0 where the B/I ratios ranged from 0.1 to 0.9, indicating the presence of immunological activity associated with relatively little biological activity. When impure human LH preparations of pituitary (69/104) and urinary (hMG 2nd IRP) origin were used as standards for the bioassay and radioimmunoassay of the hLH present in the major fractions of the pH region 7.0–9.0, significantly higher B/I ratios were obtained than with the use of the highly purified standard (68/40). These elevated B/I ratios are attributed to the presence in the impure standard preparations of immunological activity, which is associated with little or no biological activity. These observations may provide an explanation for the differences in B/I ratios which were reported for hLH in plasma, using different standard preparations." @default.
- W2113646768 created "2016-06-24" @default.
- W2113646768 creator A5007846525 @default.
- W2113646768 creator A5049062447 @default.
- W2113646768 date "1977-11-01" @default.
- W2113646768 modified "2023-09-26" @default.
- W2113646768 title "Biological and immunological characterization of human luteinizing hormone: II. A comparison of the immunological and biological activities of pituitary extracts after electrofocusing using different standard preparations" @default.
- W2113646768 cites W2026651271 @default.
- W2113646768 cites W2033417675 @default.
- W2113646768 cites W2039141140 @default.
- W2113646768 cites W2060165698 @default.
- W2113646768 cites W2077407157 @default.
- W2113646768 cites W2092226492 @default.
- W2113646768 cites W2136602688 @default.
- W2113646768 cites W2148346324 @default.
- W2113646768 cites W2149083322 @default.
- W2113646768 cites W2150860385 @default.
- W2113646768 cites W4238192488 @default.
- W2113646768 cites W4251868907 @default.
- W2113646768 doi "https://doi.org/10.1016/0303-7207(77)90046-6" @default.
- W2113646768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/590618" @default.
- W2113646768 hasPublicationYear "1977" @default.
- W2113646768 type Work @default.
- W2113646768 sameAs 2113646768 @default.
- W2113646768 citedByCount "43" @default.
- W2113646768 countsByYear W21136467682015 @default.
- W2113646768 countsByYear W21136467682016 @default.
- W2113646768 crossrefType "journal-article" @default.
- W2113646768 hasAuthorship W2113646768A5007846525 @default.
- W2113646768 hasAuthorship W2113646768A5049062447 @default.
- W2113646768 hasConcept C104488531 @default.
- W2113646768 hasConcept C116073593 @default.
- W2113646768 hasConcept C134018914 @default.
- W2113646768 hasConcept C176685330 @default.
- W2113646768 hasConcept C181199279 @default.
- W2113646768 hasConcept C185592680 @default.
- W2113646768 hasConcept C202751555 @default.
- W2113646768 hasConcept C2778575703 @default.
- W2113646768 hasConcept C43617362 @default.
- W2113646768 hasConcept C50476208 @default.
- W2113646768 hasConcept C54355233 @default.
- W2113646768 hasConcept C55493867 @default.
- W2113646768 hasConcept C71315377 @default.
- W2113646768 hasConcept C86803240 @default.
- W2113646768 hasConceptScore W2113646768C104488531 @default.
- W2113646768 hasConceptScore W2113646768C116073593 @default.
- W2113646768 hasConceptScore W2113646768C134018914 @default.
- W2113646768 hasConceptScore W2113646768C176685330 @default.
- W2113646768 hasConceptScore W2113646768C181199279 @default.
- W2113646768 hasConceptScore W2113646768C185592680 @default.
- W2113646768 hasConceptScore W2113646768C202751555 @default.
- W2113646768 hasConceptScore W2113646768C2778575703 @default.
- W2113646768 hasConceptScore W2113646768C43617362 @default.
- W2113646768 hasConceptScore W2113646768C50476208 @default.
- W2113646768 hasConceptScore W2113646768C54355233 @default.
- W2113646768 hasConceptScore W2113646768C55493867 @default.
- W2113646768 hasConceptScore W2113646768C71315377 @default.
- W2113646768 hasConceptScore W2113646768C86803240 @default.
- W2113646768 hasIssue "1" @default.
- W2113646768 hasLocation W21136467681 @default.
- W2113646768 hasLocation W21136467682 @default.
- W2113646768 hasOpenAccess W2113646768 @default.
- W2113646768 hasPrimaryLocation W21136467681 @default.
- W2113646768 hasRelatedWork W1968188747 @default.
- W2113646768 hasRelatedWork W1997292681 @default.
- W2113646768 hasRelatedWork W2001456237 @default.
- W2113646768 hasRelatedWork W2016173254 @default.
- W2113646768 hasRelatedWork W2070961736 @default.
- W2113646768 hasRelatedWork W2086118305 @default.
- W2113646768 hasRelatedWork W2113646768 @default.
- W2113646768 hasRelatedWork W2136185139 @default.
- W2113646768 hasRelatedWork W2149083322 @default.
- W2113646768 hasRelatedWork W3574144 @default.
- W2113646768 hasVolume "9" @default.
- W2113646768 isParatext "false" @default.
- W2113646768 isRetracted "false" @default.
- W2113646768 magId "2113646768" @default.
- W2113646768 workType "article" @default.