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- W2113648220 abstract "Objectives: The protein nephrin is responsible for the Finnish-type nephrotic syndrome. Anti-nephrin antibodies produced in a patient with this syndrome after renal transplantation caused massive proteinuria. Here, we report the establishment of a rat experimental model of nephrotic syndrome using rabbit IgG generated by immunization with full-length rat nephrin cDNA. Methods: Using a genetic immunization method, 8 female New Zealand white rabbits were administered full-length nephrin cDNA, a truncated nephrin cDNA containing its eight immunoglobulin-like motifs or an empty control vector. Polyclonal rabbit anti-rat nephrin IgG was administered to Wister Kyoto rats. Results: Thirteen of 18 rats injected with rabbit anti-full-length-rat nephrin IgG showed significant proteinuria, which maximally reached more than 500 mg/day. None of the 44 rats injected with rabbit anti-truncated nephrin IgG or anti-empty vector IgG showed proteinuria. All 15 rats with proteinuria showed minor glomerular abnormalities with podocyte foot process effacement. Conclusions: We successfully established a new rat model of minimal change nephrotic syndrome by genetic immunization." @default.
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- W2113648220 date "2011-09-01" @default.
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- W2113648220 title "Injection of rabbit polyclonal antibodies induced by genetic immunization with rat nephrin cDNA causes massive proteinuria in the rat: a new model of nephrotic syndrome" @default.
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