FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113650586> ?p ?o ?g. }

• W2113650586 endingPage "1715" @default.
• W2113650586 startingPage "1706" @default.
• W2113650586 abstract "Intrinsically disordered proteins and intrinsically disordered regions are implicated in many biological functions and associated with many diseases, but their conformational characterizations are challenging. The disordered β6/β7 loop of Staphylococcus aureus sortase A is involved in the binding of both sorting signals and calcium. Calcium binding allosterically activates the enzyme, but the detailed mechanism has been unclear. Here we adapted the replica exchange with solute tempering method to sample the conformations of the β6/β7 loop, in apo form and in three liganded forms (bound with a sorting signal or calcium or both). The extensive molecular dynamics simulations yield atomic details of the disordered-to-order transition of the loop and suggest a mechanism for allosteric activation: calcium binding results in partial closure and ordering of the loop, thereby leading to preorganization of the binding pocket for the sorting signal. The approach has general applicability to the study of intrinsically disordered regions." @default.
• W2113650586 created "2016-06-24" @default.
• W2113650586 creator A5011039908 @default.
• W2113650586 creator A5046197938 @default.
• W2113650586 date "2015-10-01" @default.
• W2113650586 modified "2023-10-14" @default.
• W2113650586 title "Disorder-to-Order Transition of an Active-Site Loop Mediates the Allosteric Activation of Sortase A" @default.
• W2113650586 cites W1886700512 @default.
• W2113650586 cites W1966879873 @default.
• W2113650586 cites W1984481443 @default.
• W2113650586 cites W1988872938 @default.
• W2113650586 cites W1990195838 @default.
• W2113650586 cites W1997086033 @default.
• W2113650586 cites W2006751255 @default.
• W2113650586 cites W2012772141 @default.
• W2113650586 cites W2015115860 @default.
• W2113650586 cites W2015429513 @default.
• W2113650586 cites W2032363535 @default.
• W2113650586 cites W2039903085 @default.
• W2113650586 cites W2040809566 @default.
• W2113650586 cites W2041652966 @default.
• W2113650586 cites W2061270176 @default.
• W2113650586 cites W2067174909 @default.
• W2113650586 cites W2085656056 @default.
• W2113650586 cites W2090631659 @default.
• W2113650586 cites W2100736103 @default.
• W2113650586 cites W2109463793 @default.
• W2113650586 cites W2116999379 @default.
• W2113650586 cites W2125022522 @default.
• W2113650586 cites W2128572087 @default.
• W2113650586 cites W2130094949 @default.
• W2113650586 cites W2136839950 @default.
• W2113650586 cites W2144288821 @default.
• W2113650586 cites W2146942655 @default.
• W2113650586 cites W2149181402 @default.
• W2113650586 cites W2151497682 @default.
• W2113650586 cites W2160544821 @default.
• W2113650586 cites W2164548935 @default.
• W2113650586 cites W2165581033 @default.
• W2113650586 cites W2315787946 @default.
• W2113650586 cites W2317046937 @default.
• W2113650586 cites W2318381486 @default.
• W2113650586 cites W2320042080 @default.
• W2113650586 cites W4210968583 @default.
• W2113650586 doi "https://doi.org/10.1016/j.bpj.2015.08.039" @default.
• W2113650586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4624160" @default.
• W2113650586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26488662" @default.
• W2113650586 hasPublicationYear "2015" @default.
• W2113650586 type Work @default.
• W2113650586 sameAs 2113650586 @default.
• W2113650586 citedByCount "26" @default.
• W2113650586 countsByYear W21136505862015 @default.
• W2113650586 countsByYear W21136505862016 @default.
• W2113650586 countsByYear W21136505862017 @default.
• W2113650586 countsByYear W21136505862018 @default.
• W2113650586 countsByYear W21136505862019 @default.
• W2113650586 countsByYear W21136505862020 @default.
• W2113650586 countsByYear W21136505862021 @default.
• W2113650586 countsByYear W21136505862022 @default.
• W2113650586 countsByYear W21136505862023 @default.
• W2113650586 crossrefType "journal-article" @default.
• W2113650586 hasAuthorship W2113650586A5011039908 @default.
• W2113650586 hasAuthorship W2113650586A5046197938 @default.
• W2113650586 hasBestOaLocation W21136505861 @default.
• W2113650586 hasConcept C104317684 @default.
• W2113650586 hasConcept C114614502 @default.
• W2113650586 hasConcept C122229402 @default.
• W2113650586 hasConcept C12554922 @default.
• W2113650586 hasConcept C147597530 @default.
• W2113650586 hasConcept C166342909 @default.
• W2113650586 hasConcept C178790620 @default.
• W2113650586 hasConcept C181199279 @default.
• W2113650586 hasConcept C184670325 @default.
• W2113650586 hasConcept C185592680 @default.
• W2113650586 hasConcept C2777339483 @default.
• W2113650586 hasConcept C2778815515 @default.
• W2113650586 hasConcept C2778839769 @default.
• W2113650586 hasConcept C2993175405 @default.
• W2113650586 hasConcept C33923547 @default.
• W2113650586 hasConcept C519063684 @default.
• W2113650586 hasConcept C55493867 @default.
• W2113650586 hasConcept C59593255 @default.
• W2113650586 hasConcept C71240020 @default.
• W2113650586 hasConcept C8010536 @default.
• W2113650586 hasConcept C86803240 @default.
• W2113650586 hasConceptScore W2113650586C104317684 @default.
• W2113650586 hasConceptScore W2113650586C114614502 @default.
• W2113650586 hasConceptScore W2113650586C122229402 @default.
• W2113650586 hasConceptScore W2113650586C12554922 @default.
• W2113650586 hasConceptScore W2113650586C147597530 @default.
• W2113650586 hasConceptScore W2113650586C166342909 @default.
• W2113650586 hasConceptScore W2113650586C178790620 @default.
• W2113650586 hasConceptScore W2113650586C181199279 @default.
• W2113650586 hasConceptScore W2113650586C184670325 @default.
• W2113650586 hasConceptScore W2113650586C185592680 @default.
• W2113650586 hasConceptScore W2113650586C2777339483 @default.
• W2113650586 hasConceptScore W2113650586C2778815515 @default.
• W2113650586 hasConceptScore W2113650586C2778839769 @default.

• next