FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113651744> ?p ?o ?g. }

• W2113651744 abstract "Glutathione S-transferase omega-1 and 2 genes (GSTO1, GSTO2), residing within an Alzheimer and Parkinson disease (AD and PD) linkage region, have diverse functions including mitigation of oxidative stress and may underlie the pathophysiology of both diseases. GSTO polymorphisms were previously reported to associate with risk and age-at-onset of these diseases, although inconsistent follow-up study designs make interpretation of results difficult. We assessed two previously reported SNPs, GSTO1 rs4925 and GSTO2 rs156697, in AD (3,493 ADs vs. 4,617 controls) and PD (678 PDs vs. 712 controls) for association with disease risk (case-controls), age-at-diagnosis (cases) and brain gene expression levels (autopsied subjects).We found that rs156697 minor allele associates with significantly increased risk (odds ratio = 1.14, p = 0.038) in the older ADs with age-at-diagnosis > 80 years. The minor allele of GSTO1 rs4925 associates with decreased risk in familial PD (odds ratio = 0.78, p = 0.034). There was no other association with disease risk or age-at-diagnosis. The minor alleles of both GSTO SNPs associate with lower brain levels of GSTO2 (p = 4.7 × 10-11-1.9 × 10-27), but not GSTO1. Pathway analysis of significant genes in our brain expression GWAS, identified significant enrichment for glutathione metabolism genes (p = 0.003).These results suggest that GSTO locus variants may lower brain GSTO2 levels and consequently confer AD risk in older age. Other glutathione metabolism genes should be assessed for their effects on AD and other chronic, neurologic diseases." @default.
• W2113651744 created "2016-06-24" @default.
• W2113651744 creator A5001451054 @default.
• W2113651744 creator A5005195577 @default.
• W2113651744 creator A5009044500 @default.
• W2113651744 creator A5009533777 @default.
• W2113651744 creator A5010157023 @default.
• W2113651744 creator A5013727426 @default.
• W2113651744 creator A5020651939 @default.
• W2113651744 creator A5020865969 @default.
• W2113651744 creator A5022481370 @default.
• W2113651744 creator A5025899099 @default.
• W2113651744 creator A5028101300 @default.
• W2113651744 creator A5028753204 @default.
• W2113651744 creator A5029871478 @default.
• W2113651744 creator A5030588426 @default.
• W2113651744 creator A5037436368 @default.
• W2113651744 creator A5040519239 @default.
• W2113651744 creator A5042029327 @default.
• W2113651744 creator A5044404099 @default.
• W2113651744 creator A5045246745 @default.
• W2113651744 creator A5046953046 @default.
• W2113651744 creator A5051222892 @default.
• W2113651744 creator A5056889293 @default.
• W2113651744 creator A5057196521 @default.
• W2113651744 creator A5060892086 @default.
• W2113651744 creator A5074593768 @default.
• W2113651744 creator A5077545737 @default.
• W2113651744 creator A5079471809 @default.
• W2113651744 creator A5080705428 @default.
• W2113651744 creator A5088138090 @default.
• W2113651744 creator A5088891117 @default.
• W2113651744 creator A5089218471 @default.
• W2113651744 creator A5091046259 @default.
• W2113651744 creator A5091373999 @default.
• W2113651744 creator A5091854106 @default.
• W2113651744 date "2012-04-11" @default.
• W2113651744 modified "2023-10-16" @default.
• W2113651744 title "Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications." @default.
• W2113651744 cites W1966831629 @default.
• W2113651744 cites W1970242970 @default.
• W2113651744 cites W1970831257 @default.
• W2113651744 cites W1972488785 @default.
• W2113651744 cites W1976690731 @default.
• W2113651744 cites W1980991473 @default.
• W2113651744 cites W1984737558 @default.
• W2113651744 cites W1984777465 @default.
• W2113651744 cites W2005752286 @default.
• W2113651744 cites W2008827081 @default.
• W2113651744 cites W2011837326 @default.
• W2113651744 cites W2032564883 @default.
• W2113651744 cites W2033552121 @default.
• W2113651744 cites W2038285066 @default.
• W2113651744 cites W2039531063 @default.
• W2113651744 cites W2047565527 @default.
• W2113651744 cites W2056169229 @default.
• W2113651744 cites W2057888684 @default.
• W2113651744 cites W2064579827 @default.
• W2113651744 cites W2068605672 @default.
• W2113651744 cites W2069960269 @default.
• W2113651744 cites W2070742699 @default.
• W2113651744 cites W2072822799 @default.
• W2113651744 cites W2074212776 @default.
• W2113651744 cites W2074835372 @default.
• W2113651744 cites W2092162796 @default.
• W2113651744 cites W2097912344 @default.
• W2113651744 cites W2105010972 @default.
• W2113651744 cites W2106608030 @default.
• W2113651744 cites W2107328434 @default.
• W2113651744 cites W2117610858 @default.
• W2113651744 cites W2119279196 @default.
• W2113651744 cites W2121820194 @default.
• W2113651744 cites W2126118928 @default.
• W2113651744 cites W2128476271 @default.
• W2113651744 cites W2129432937 @default.
• W2113651744 cites W2129494556 @default.
• W2113651744 cites W2131937786 @default.
• W2113651744 cites W2133557496 @default.
• W2113651744 cites W2135249035 @default.
• W2113651744 cites W2139130775 @default.
• W2113651744 cites W2139647754 @default.
• W2113651744 cites W2142068079 @default.
• W2113651744 cites W2142814611 @default.
• W2113651744 cites W2145210308 @default.
• W2113651744 cites W2145532935 @default.
• W2113651744 cites W2148641246 @default.
• W2113651744 cites W2149541458 @default.
• W2113651744 cites W2152119060 @default.
• W2113651744 cites W2154441086 @default.
• W2113651744 cites W2156220037 @default.
• W2113651744 cites W2161633633 @default.
• W2113651744 cites W2162530578 @default.
• W2113651744 cites W2313660162 @default.
• W2113651744 cites W3214092816 @default.
• W2113651744 cites W6733712 @default.
• W2113651744 doi "https://doi.org/10.1186/1750-1326-7-13" @default.
• W2113651744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3393625" @default.
• W2113651744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22494505" @default.
• W2113651744 hasPublicationYear "2012" @default.
• W2113651744 type Work @default.

• next