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• W2113657333 abstract "Objective— To compare the effects of intranasal and oral administration of 17β-estradiol (E 2 ) and norethisterone(acetate) [NET(A)] in healthy postmenopausal women on activated protein C (APC) resistance and other hemostatic parameters associated with venous thrombosis. Methods and Results— In this 2-center, randomized, double-blind, 1-year trial, 90 postmenopausal women (56.6±4.7 years of age) received daily either an intranasal spray with 175 μg/275 μg E 2 /NET (n=47) or 1 mg/0.5 mg oral E 2 /NETA (n=43). Normalized APC sensitivity ratios (nAPCsr) were determined with a thrombin generation-based APC resistance test. After 1 year, the increase in nAPCsr was smaller in the intranasal than in the oral group: 11% (95% CI, 1% to 22%) versus 53% (95% CI, 37% to 72%). Overall, the decrease in antithrombin and increase in prothrombin fragment 1+2 (F1+2) were smaller and the decrease in free protein S larger in the intranasal compared with the oral group after 1 year. In both groups, the decreases in protein C and prothrombin, and the increase in d -dimer were similar. Conclusion— Compared with oral E 2 /NETA therapy, intranasal administration of E 2 /NET had less effect on APC resistance and on a number of other parameters associated with venous thrombosis. This observation suggests the possibility of a lower venous thrombosis risk for intranasal E 2 /NET compared with oral therapy." @default.
• W2113657333 created "2016-06-24" @default.
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• W2113657333 date "2006-07-01" @default.
• W2113657333 modified "2023-09-27" @default.
• W2113657333 title "Less Effect of Intranasal Than Oral Hormone Therapy on Factors Associated With Venous Thrombosis Risk in Healthy Postmenopausal Women" @default.
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• W2113657333 doi "https://doi.org/10.1161/01.atv.0000224325.96659.53" @default.
• W2113657333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16645152" @default.
• W2113657333 hasPublicationYear "2006" @default.
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