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- W2113670054 abstract "Essential tremor (ET) is one of the most common and most disabling movement disorders among adults. The drug treatment of ET remains unsatisfactory. Additional therapies are required for patients with inadequate response or intolerable side effects. The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA receptor antagonist) on the harmaline model of transient action tremor. The effects of memantine were further compared with ethanol. Three separate groups of male Wistar rats were injected either with saline, ethanol (1.5 gr/kg), or memantine (5 mg/kg) 15 min prior to a single intraperitoneal injection of harmaline (20 mg/kg). Tremor and locomotion were evaluated by a custom-built tremor and locomotion analysis system. After 24 h of harmaline injection, cellular viability, and apoptosis were assessed using crystal violet staining, and caspase-3 immunostaining, respectively. Harmaline caused neuronal cell loss and caspase-3 mediated apoptosis in cerebellar granular and purkinje cells as well as the inferior olivary neurons. Despite a reduction in tremor intensity and duration with ethanol, this compound resulted in cell loss in cerebellum and olivary nucleus. Memantine exhibited neuroprotective efficacy on cerebellar and inferior olivary neurons albeit weaker anti-tremor effect compared to ethanol. In conclusion, anti-tremogenic and neuroprotective effects do not necessarily overlap. Memantine is a potential treatment for ET particularly given its neuroprotective efficacy." @default.
- W2113670054 created "2016-06-24" @default.
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- W2113670054 date "2011-09-01" @default.
- W2113670054 modified "2023-10-01" @default.
- W2113670054 title "The effect of memantine in harmaline-induced tremor and neurodegeneration" @default.
- W2113670054 cites W1495146857 @default.
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- W2113670054 cites W1970175928 @default.
- W2113670054 cites W1970520445 @default.
- W2113670054 cites W1971837740 @default.
- W2113670054 cites W1973816823 @default.
- W2113670054 cites W1974995870 @default.
- W2113670054 cites W1988480319 @default.
- W2113670054 cites W1990042297 @default.
- W2113670054 cites W1990984446 @default.
- W2113670054 cites W1991958044 @default.
- W2113670054 cites W1993817377 @default.
- W2113670054 cites W1994413077 @default.
- W2113670054 cites W2001431383 @default.
- W2113670054 cites W2003499871 @default.
- W2113670054 cites W2003949829 @default.
- W2113670054 cites W2007589759 @default.
- W2113670054 cites W2009590517 @default.
- W2113670054 cites W2010074472 @default.
- W2113670054 cites W2013607848 @default.
- W2113670054 cites W2014004733 @default.
- W2113670054 cites W2015427019 @default.
- W2113670054 cites W2016001539 @default.
- W2113670054 cites W2019543468 @default.
- W2113670054 cites W2027340604 @default.
- W2113670054 cites W2029994068 @default.
- W2113670054 cites W2046371100 @default.
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- W2113670054 cites W2050202370 @default.
- W2113670054 cites W2051994523 @default.
- W2113670054 cites W2058442853 @default.
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- W2113670054 cites W2063380813 @default.
- W2113670054 cites W2063563853 @default.
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- W2113670054 cites W2072518603 @default.
- W2113670054 cites W2074823342 @default.
- W2113670054 cites W2079611035 @default.
- W2113670054 cites W2081549844 @default.
- W2113670054 cites W2081552801 @default.
- W2113670054 cites W2085580182 @default.
- W2113670054 cites W2086178644 @default.
- W2113670054 cites W2086797939 @default.
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- W2113670054 doi "https://doi.org/10.1016/j.neuropharm.2011.05.015" @default.
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