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• W2113670429 abstract "Target-activatable fluorogenic probes based on gold nanoparticles (AuNPs) functionalized with self-assembled heterogeneous monolayers of dye-labeled peptides and poly(ethylene glycol) have been developed to visualize proteolytic activity in vivo. A one-step synthesis strategy that allows simple generation of surface-defined AuNP probe libraries is presented as a means of tailoring and evaluating probe characteristics for maximal fluorescence enhancement after protease activation. Optimal AuNP probes targeted to trypsin and urokinase-type plasminogen activator required the incorporation of a dark quencher to achieve 5- to 8-fold signal amplification. These probes exhibited extended circulation time in vivo and high image contrast in a mouse tumor model." @default.
• W2113670429 created "2016-06-24" @default.
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• W2113670429 date "2010-02-10" @default.
• W2113670429 modified "2023-10-10" @default.
• W2113670429 title "Self-Assembled Gold Nanoparticle Molecular Probes for Detecting Proteolytic Activity <i>In Vivo</i>" @default.
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• W2113670429 doi "https://doi.org/10.1021/nn9017334" @default.
• W2113670429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2847389" @default.
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• W2113670429 hasPublicationYear "2010" @default.
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