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- W2113676592 abstract "Integrin ανβ3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an ανβ3-targeted nanoparticle (NP) encapsulating the cytotoxic drug doxorubicin (Dox) for targeted drug delivery to the ανβ3-expressing tumor vasculature. We observed real-time targeting of this NP to tumor vessels and noted selective apoptosis in regions of the ανβ3-expressing tumor vasculature. In clinically relevant pancreatic and renal cell orthotopic models of spontaneous metastasis, targeted delivery of Dox produced an antimetastatic effect. In fact, ανβ3-mediated delivery of this drug to the tumor vasculature resulted in a 15-fold increase in antimetastatic activity without producing drug-associated weight loss as observed with systemic administration of the free drug. These findings reveal that NP-based delivery of cytotoxic drugs to the ανβ3-positive tumor vasculature represents an approach for treating metastatic disease." @default.
- W2113676592 created "2016-06-24" @default.
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- W2113676592 date "2008-07-08" @default.
- W2113676592 modified "2023-10-03" @default.
- W2113676592 title "Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis" @default.
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- W2113676592 doi "https://doi.org/10.1073/pnas.0803728105" @default.
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