Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113678733> ?p ?o ?g. }
- W2113678733 endingPage "537" @default.
- W2113678733 startingPage "523" @default.
- W2113678733 abstract "Meningococcal disease remains a significant global cause of morbidity and mortality despite the availability of polysaccharide and conjugate vaccines. The implementation of monovalent meningococcal serogroup C vaccine in developed countries has significantly decreased the incidence of meningococcal disease, while the recent introduction of monovalent serogroup A conjugate vaccine in the African meningitis belt aims to reduce the incidence of high endemic disease in this area. Three quadrivalent meningococcal vaccines have already been licensed; a polysaccharide (MenACWY-PS) and two conjugated (MenACWY-DT and MenACWY-CRM) vaccines. An investigational MenACWY-TT vaccine is described in this article. Clinical trials in infants older than 9 months of age, toddlers, children, adolescents and adults have indicated that this vaccine is well tolerated and immunogenic. The inclusion of a spacer molecule coupled with the polysaccharide (for serogroups A and C) and tetanus toxoid as the carrier protein aims to elicit robust immune responses. The tolerability of this vaccine is comparable to that of polysaccharide quadrivalent vaccines and monovalent meningococcal serogroup C vaccines. More importantly, the immunogenicity, antibody persistence and induction of immune memory aim to provide protection to a wide range of susceptible subjects." @default.
- W2113678733 created "2016-06-24" @default.
- W2113678733 creator A5000434332 @default.
- W2113678733 creator A5056145906 @default.
- W2113678733 date "2012-05-01" @default.
- W2113678733 modified "2023-09-26" @default.
- W2113678733 title "MenACWY-TT vaccine for active immunization against invasive meningococcal disease" @default.
- W2113678733 cites W1565773612 @default.
- W2113678733 cites W1584761021 @default.
- W2113678733 cites W1976717129 @default.
- W2113678733 cites W1976881351 @default.
- W2113678733 cites W1978770438 @default.
- W2113678733 cites W1978789711 @default.
- W2113678733 cites W1979469701 @default.
- W2113678733 cites W1980927941 @default.
- W2113678733 cites W1984338589 @default.
- W2113678733 cites W1986910419 @default.
- W2113678733 cites W1987029428 @default.
- W2113678733 cites W1989011168 @default.
- W2113678733 cites W1992790837 @default.
- W2113678733 cites W2002571551 @default.
- W2113678733 cites W2008438078 @default.
- W2113678733 cites W2012506967 @default.
- W2113678733 cites W2013244135 @default.
- W2113678733 cites W2016357226 @default.
- W2113678733 cites W2020311917 @default.
- W2113678733 cites W2027531878 @default.
- W2113678733 cites W2030178991 @default.
- W2113678733 cites W2033366028 @default.
- W2113678733 cites W2036856545 @default.
- W2113678733 cites W2037298804 @default.
- W2113678733 cites W2040546171 @default.
- W2113678733 cites W2046127942 @default.
- W2113678733 cites W2046910135 @default.
- W2113678733 cites W2049628926 @default.
- W2113678733 cites W2049865589 @default.
- W2113678733 cites W2050277020 @default.
- W2113678733 cites W2055298296 @default.
- W2113678733 cites W2057222301 @default.
- W2113678733 cites W2059317137 @default.
- W2113678733 cites W2061372708 @default.
- W2113678733 cites W2062524491 @default.
- W2113678733 cites W2067331760 @default.
- W2113678733 cites W2071305953 @default.
- W2113678733 cites W2075892057 @default.
- W2113678733 cites W2076756245 @default.
- W2113678733 cites W2077486234 @default.
- W2113678733 cites W2082705433 @default.
- W2113678733 cites W2086136356 @default.
- W2113678733 cites W2086965801 @default.
- W2113678733 cites W2088322834 @default.
- W2113678733 cites W2089775764 @default.
- W2113678733 cites W2091379198 @default.
- W2113678733 cites W2095551099 @default.
- W2113678733 cites W2098814980 @default.
- W2113678733 cites W2099215615 @default.
- W2113678733 cites W2100080502 @default.
- W2113678733 cites W2106420760 @default.
- W2113678733 cites W2108462386 @default.
- W2113678733 cites W2110281146 @default.
- W2113678733 cites W2113019470 @default.
- W2113678733 cites W2121283148 @default.
- W2113678733 cites W2126724314 @default.
- W2113678733 cites W2128589740 @default.
- W2113678733 cites W2129094433 @default.
- W2113678733 cites W2129920904 @default.
- W2113678733 cites W2133175215 @default.
- W2113678733 cites W2134945394 @default.
- W2113678733 cites W2137053577 @default.
- W2113678733 cites W2137586712 @default.
- W2113678733 cites W2140617263 @default.
- W2113678733 cites W2141226147 @default.
- W2113678733 cites W2155721781 @default.
- W2113678733 cites W2156326603 @default.
- W2113678733 cites W2157076815 @default.
- W2113678733 cites W2158137570 @default.
- W2113678733 cites W2159099211 @default.
- W2113678733 cites W2160538431 @default.
- W2113678733 cites W2160815828 @default.
- W2113678733 cites W2162169494 @default.
- W2113678733 cites W2162319245 @default.
- W2113678733 cites W2167186265 @default.
- W2113678733 cites W2171028861 @default.
- W2113678733 cites W2205937034 @default.
- W2113678733 cites W2242672992 @default.
- W2113678733 cites W2316757333 @default.
- W2113678733 cites W4249066710 @default.
- W2113678733 doi "https://doi.org/10.1586/erv.12.32" @default.
- W2113678733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22827239" @default.
- W2113678733 hasPublicationYear "2012" @default.
- W2113678733 type Work @default.
- W2113678733 sameAs 2113678733 @default.
- W2113678733 citedByCount "24" @default.
- W2113678733 countsByYear W21136787332012 @default.
- W2113678733 countsByYear W21136787332013 @default.
- W2113678733 countsByYear W21136787332014 @default.
- W2113678733 countsByYear W21136787332015 @default.
- W2113678733 countsByYear W21136787332016 @default.