FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113679967> ?p ?o ?g. }

• W2113679967 endingPage "77" @default.
• W2113679967 startingPage "65" @default.
• W2113679967 abstract "Trinucleotide repeats can form secondary structures, whose inappropriate repair or replication can lead to repeat expansions. There are multiple loci within the human genome where expansion of trinucleotide repeats leads to disease. Although it is known that expanded repeats accumulate double-strand breaks (DSBs), it is not known which DSB repair pathways act on such lesions and whether inaccurate DSB repair pathways contribute to repeat expansions. Using Saccharomyces cerevisiae, we found that CAG/CTG tracts of 70 or 155 repeats exhibited significantly elevated levels of breakage and expansions in strains lacking MRE11, implicating the Mre11/Rad50/Xrs2 complex in repairing lesions at structure-forming repeats. About two-thirds of the expansions that occurred in the absence of MRE11 were dependent on RAD52, implicating aberrant homologous recombination as a mechanism for generating expansions. Expansions were also elevated in a sae2 deletion background and these were not dependent on RAD52, supporting an additional role for Mre11 in facilitating Sae2-dependent hairpin processing at the repeat. Mre11 nuclease activity and Tel1-dependent checkpoint functions were largely dispensable for repeat maintenance. In addition, we found that intact homologous recombination and nonhomologous end-joining pathways of DSB repair are needed to prevent repeat fragility and that both pathways also protect against repeat instability. We conclude that failure of principal DSB repair pathways to repair breaks that occur within the repeats can result in the accumulation of atypical intermediates, whose aberrant resolution will then lead to CAG expansions, contractions, and repeat-mediated chromosomal fragility." @default.
• W2113679967 created "2016-06-24" @default.
• W2113679967 creator A5001471671 @default.
• W2113679967 creator A5041486468 @default.
• W2113679967 creator A5054979849 @default.
• W2113679967 creator A5078697902 @default.
• W2113679967 date "2010-01-01" @default.
• W2113679967 modified "2023-10-06" @default.
• W2113679967 title "Double-Strand Break Repair Pathways Protect against CAG/CTG Repeat Expansions, Contractions and Repeat-Mediated Chromosomal Fragility in <i>Saccharomyces cerevisiae</i>" @default.
• W2113679967 cites W1501673396 @default.
• W2113679967 cites W1575498014 @default.
• W2113679967 cites W1597824427 @default.
• W2113679967 cites W1966072209 @default.
• W2113679967 cites W1973631828 @default.
• W2113679967 cites W1973906344 @default.
• W2113679967 cites W1974971445 @default.
• W2113679967 cites W1977829734 @default.
• W2113679967 cites W1984919526 @default.
• W2113679967 cites W1987246047 @default.
• W2113679967 cites W1993026474 @default.
• W2113679967 cites W1993913655 @default.
• W2113679967 cites W1994770492 @default.
• W2113679967 cites W2002231685 @default.
• W2113679967 cites W2003054268 @default.
• W2113679967 cites W2004099247 @default.
• W2113679967 cites W2006764478 @default.
• W2113679967 cites W2008668090 @default.
• W2113679967 cites W2014223000 @default.
• W2113679967 cites W2015181216 @default.
• W2113679967 cites W2019239618 @default.
• W2113679967 cites W2020884359 @default.
• W2113679967 cites W2023608297 @default.
• W2113679967 cites W2024558473 @default.
• W2113679967 cites W2025051341 @default.
• W2113679967 cites W2033229710 @default.
• W2113679967 cites W2035323777 @default.
• W2113679967 cites W2036212209 @default.
• W2113679967 cites W2042160009 @default.
• W2113679967 cites W2044884266 @default.
• W2113679967 cites W2051052655 @default.
• W2113679967 cites W2052714004 @default.
• W2113679967 cites W2053919212 @default.
• W2113679967 cites W2054341187 @default.
• W2113679967 cites W2057211837 @default.
• W2113679967 cites W2057787531 @default.
• W2113679967 cites W2067466498 @default.
• W2113679967 cites W2069157381 @default.
• W2113679967 cites W2072208660 @default.
• W2113679967 cites W2073315036 @default.
• W2113679967 cites W2080408951 @default.
• W2113679967 cites W2082981258 @default.
• W2113679967 cites W2086707417 @default.
• W2113679967 cites W2094020226 @default.
• W2113679967 cites W2094502358 @default.
• W2113679967 cites W2099518892 @default.
• W2113679967 cites W2108570063 @default.
• W2113679967 cites W2113189443 @default.
• W2113679967 cites W2115237139 @default.
• W2113679967 cites W2115595801 @default.
• W2113679967 cites W2122259228 @default.
• W2113679967 cites W2122931341 @default.
• W2113679967 cites W2123702933 @default.
• W2113679967 cites W2124919704 @default.
• W2113679967 cites W2126492332 @default.
• W2113679967 cites W2131173813 @default.
• W2113679967 cites W2132920733 @default.
• W2113679967 cites W2133554835 @default.
• W2113679967 cites W2134844472 @default.
• W2113679967 cites W2136218692 @default.
• W2113679967 cites W2151469819 @default.
• W2113679967 cites W2154287511 @default.
• W2113679967 cites W2156282115 @default.
• W2113679967 cites W2157462132 @default.
• W2113679967 cites W2158436225 @default.
• W2113679967 cites W2161560609 @default.
• W2113679967 cites W2168815980 @default.
• W2113679967 cites W2170450010 @default.
• W2113679967 cites W2415805387 @default.
• W2113679967 cites W4254536048 @default.
• W2113679967 cites W4378744814 @default.
• W2113679967 doi "https://doi.org/10.1534/genetics.109.111039" @default.
• W2113679967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2815931" @default.
• W2113679967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19901069" @default.
• W2113679967 hasPublicationYear "2010" @default.
• W2113679967 type Work @default.
• W2113679967 sameAs 2113679967 @default.
• W2113679967 citedByCount "59" @default.
• W2113679967 countsByYear W21136799672012 @default.
• W2113679967 countsByYear W21136799672013 @default.
• W2113679967 countsByYear W21136799672014 @default.
• W2113679967 countsByYear W21136799672015 @default.
• W2113679967 countsByYear W21136799672016 @default.
• W2113679967 countsByYear W21136799672017 @default.
• W2113679967 countsByYear W21136799672018 @default.
• W2113679967 countsByYear W21136799672019 @default.
• W2113679967 countsByYear W21136799672020 @default.
• W2113679967 countsByYear W21136799672021 @default.
• W2113679967 countsByYear W21136799672022 @default.

• next