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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113688855> ?p ?o ?g. }

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• W2113688855 abstract "A patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion of the lung parenchyma. We used conditional reprogramming to generate cell cultures from the patient's normal and tumorous lung tissue. Analysis revealed that the laryngeal tumor cells contained a wild-type 7.9-kb human papillomavirus virus type 11 (HPV-11) genome, whereas the pulmonary tumor cells contained a 10.4-kb genome. The increased size of the latter viral genome was due to duplication of the promoter and oncogene regions. Chemosensitivity testing identified vorinostat as a potential therapeutic agent. At 3 months after treatment initiation, tumor sizes had stabilized, with durable effects at 15 months." @default.
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• W2113688855 date "2012-09-27" @default.
• W2113688855 modified "2023-10-01" @default.
• W2113688855 title "Use of Reprogrammed Cells to Identify Therapy for Respiratory Papillomatosis" @default.
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• W2113688855 doi "https://doi.org/10.1056/nejmoa1203055" @default.
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