FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113703059> ?p ?o ?g. }

• W2113703059 endingPage "3544" @default.
• W2113703059 startingPage "3537" @default.
• W2113703059 abstract "ABSTRACT We have analyzed the profiles of 23 of Plasmodium falciparum strains for their in vitro chemosusceptibilities to piperaquine (PPQ), dihydroartemisinin (DHA), chloroquine, monodesethylamodiaquine, quinine, mefloquine, lumefantrine, atovaquone, pyrimethamine, and doxycycline (DOX) in association with polymorphisms in genes involved in quinoline resistance ( Plasmodium falciparum crt [ pfcrt ], pfmdr1 , pfmrp , and pfnhe ). The 50% inhibitory concentrations (IC 50 s) for PPQ ranged from 29 to 98 nM (geometric mean = 57.8 nM, 95% confidence interval [CI] = 51 to 65) and from 0.4 to 5.8 nM for DHA (geometric mean = 1.8 nM, 95% CI = 1.4 to 2.3). We found a significant positive correlation between the responses to PPQ and DHA ( r 2 = 0.17; P = 0.0495) and between the responses to PPQ and DOX ( r 2 = 0.41; P = 0.001). We did not find a significant association between the PPQ IC 50 (0.0525 < P < 0.9247) or the DHA IC 50 (0.0138 < P < 0.9018) and polymorphisms in the pfcrt , pfmdr1 , pfmrp , and pfnhe-1 genes. There was an absence of cross-resistance with quinolines, and the IC 50 s for PPQ and DHA were found to be unrelated to mutations in the pfcrt , pfmdr1 , pfmrp , and pfnhe-1 transport protein genes, which are involved in quinoline antimalarial drug resistance. These results confirm the interest in and the efficacy of the combination of PPQ and DHA for areas in which parasites are resistant to chloroquine or other quinolines." @default.
• W2113703059 created "2016-06-24" @default.
• W2113703059 creator A5000004024 @default.
• W2113703059 creator A5017517214 @default.
• W2113703059 creator A5047978694 @default.
• W2113703059 creator A5055728449 @default.
• W2113703059 creator A5065085067 @default.
• W2113703059 creator A5078098543 @default.
• W2113703059 creator A5078357918 @default.
• W2113703059 creator A5079362938 @default.
• W2113703059 date "2010-09-01" @default.
• W2113703059 modified "2023-09-27" @default.
• W2113703059 title "Absence of Association between Piperaquine <i>In Vitro</i> Responses and Polymorphisms in the <i>pfcrt</i> , <i>pfmdr1</i> , <i>pfmrp</i> , and <i>pfnhe</i> Genes in <i>Plasmodium falciparum</i>" @default.
• W2113703059 cites W1525810389 @default.
• W2113703059 cites W1694215848 @default.
• W2113703059 cites W1921967810 @default.
• W2113703059 cites W1968109769 @default.
• W2113703059 cites W1970856471 @default.
• W2113703059 cites W1975267889 @default.
• W2113703059 cites W1996418116 @default.
• W2113703059 cites W2003127960 @default.
• W2113703059 cites W2006909094 @default.
• W2113703059 cites W2007852671 @default.
• W2113703059 cites W2013035959 @default.
• W2113703059 cites W2014392076 @default.
• W2113703059 cites W2020251171 @default.
• W2113703059 cites W2020899937 @default.
• W2113703059 cites W2028914548 @default.
• W2113703059 cites W2040713555 @default.
• W2113703059 cites W2048834380 @default.
• W2113703059 cites W2052262611 @default.
• W2113703059 cites W2059822930 @default.
• W2113703059 cites W2061999977 @default.
• W2113703059 cites W2070473135 @default.
• W2113703059 cites W2074450319 @default.
• W2113703059 cites W2082480743 @default.
• W2113703059 cites W2082992930 @default.
• W2113703059 cites W2094103969 @default.
• W2113703059 cites W2097760506 @default.
• W2113703059 cites W2100350165 @default.
• W2113703059 cites W2100435538 @default.
• W2113703059 cites W2101114302 @default.
• W2113703059 cites W2101775642 @default.
• W2113703059 cites W2104355399 @default.
• W2113703059 cites W2106346927 @default.
• W2113703059 cites W2106499501 @default.
• W2113703059 cites W2111813303 @default.
• W2113703059 cites W2115398829 @default.
• W2113703059 cites W2116219018 @default.
• W2113703059 cites W2126630384 @default.
• W2113703059 cites W2126753952 @default.
• W2113703059 cites W2128743785 @default.
• W2113703059 cites W2130573393 @default.
• W2113703059 cites W2133117999 @default.
• W2113703059 cites W2135011211 @default.
• W2113703059 cites W2147185046 @default.
• W2113703059 cites W2150269854 @default.
• W2113703059 cites W2150522686 @default.
• W2113703059 cites W2157499338 @default.
• W2113703059 cites W2161311583 @default.
• W2113703059 cites W2163995382 @default.
• W2113703059 cites W2164713083 @default.
• W2113703059 cites W2168267195 @default.
• W2113703059 cites W2189162895 @default.
• W2113703059 doi "https://doi.org/10.1128/aac.00183-10" @default.
• W2113703059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2935001" @default.
• W2113703059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20547801" @default.
• W2113703059 hasPublicationYear "2010" @default.
• W2113703059 type Work @default.
• W2113703059 sameAs 2113703059 @default.
• W2113703059 citedByCount "44" @default.
• W2113703059 countsByYear W21137030592012 @default.
• W2113703059 countsByYear W21137030592013 @default.
• W2113703059 countsByYear W21137030592014 @default.
• W2113703059 countsByYear W21137030592015 @default.
• W2113703059 countsByYear W21137030592016 @default.
• W2113703059 countsByYear W21137030592017 @default.
• W2113703059 countsByYear W21137030592018 @default.
• W2113703059 countsByYear W21137030592019 @default.
• W2113703059 countsByYear W21137030592020 @default.
• W2113703059 countsByYear W21137030592021 @default.
• W2113703059 countsByYear W21137030592022 @default.
• W2113703059 crossrefType "journal-article" @default.
• W2113703059 hasAuthorship W2113703059A5000004024 @default.
• W2113703059 hasAuthorship W2113703059A5017517214 @default.
• W2113703059 hasAuthorship W2113703059A5047978694 @default.
• W2113703059 hasAuthorship W2113703059A5055728449 @default.
• W2113703059 hasAuthorship W2113703059A5065085067 @default.
• W2113703059 hasAuthorship W2113703059A5078098543 @default.
• W2113703059 hasAuthorship W2113703059A5078357918 @default.
• W2113703059 hasAuthorship W2113703059A5079362938 @default.
• W2113703059 hasBestOaLocation W21137030592 @default.
• W2113703059 hasConcept C114851261 @default.
• W2113703059 hasConcept C159047783 @default.
• W2113703059 hasConcept C203014093 @default.
• W2113703059 hasConcept C2776120307 @default.
• W2113703059 hasConcept C2776992834 @default.
• W2113703059 hasConcept C2777199930 @default.

• next