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- W2113703378 abstract "Abstract The purpose of this study is to characterize the cytoplasmic progesterone receptor of the ovarian-dependent MXT mouse mammary tumor line and to demonstrate that the levels of this receptor are under positive control by estrogen. MXT-3590 is a transplantable mouse mammary tumor line originally induced by urethan treatment in C57BL × DBAf F 1 mice. The tumor is an ovarian-dependent well-differentiated ductal carcinoma which responds by rapid growth to estradiol benzoate and to medroxyprogesterone acetate (Depo Provera). These hormones given simultaneously result in a greater than additive growth effect. This synergism indicates that progesterone has no antagonistic effect on estrogen action as it does in many other model systems. Progesterone receptor was measured at 4° with [ 3 H]progesterone in a brief exposure dextran-coated charcoal assay. The dissociation constant of the cytoplasmic receptor is approximately 5 nm, and the binding was specific for progesterone and its synthetic analog R5020. Specific progesterone binding appeared in both the 4S and 8S regions of 5 to 20% postlabeled sucrose density gradients. The quantity of progesterone receptor measured in MXT-3590 (28 fmol/mg tissue) falls after ovariectomy (5 fmol/mg tissue) and increases (20 fmol/mg tissue) following a s.c. injection of 2.5 µg of estradiol-17β. Thus, MXT-3590 provides evidence in an experimental mammary carcinoma for the association between estrogen action and positive progesterone receptor control. By virtue of its readily measured and well-characterized estrogen and progesterone receptors, MXT-3590 provides a promising model system in which to study growth control by estrogen and progesterone in a neoplastic tissue." @default.
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- W2113703378 date "1979-10-01" @default.
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- W2113703378 title "Characterization and estrogen stimulation of cytoplasmic progesterone receptor in the ovarian-dependent MXT-3590 mammary tumor line." @default.
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